Gallic acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.243778
ELL2 elongation factor, RNA polymerase II, 2 0.208066
MCL1 myeloid cell leukemia 1 0.132347
LMO7 LIM domain 7 0.132079
ERRFI1 ERBB receptor feedback inhibitor 1 0.103978
TOP1 topoisomerase (DNA) I 0.102562
PM20D1 peptidase M20 domain containing 1 0.0979009
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0774441
BCAR3 breast cancer anti-estrogen resistance 3 0.069517
PDE4D phosphodiesterase 4D, cAMP-specific 0.0674212
DSPP dentin sialophosphoprotein 0.0605809
CES1 carboxylesterase 1 0.0579839
INTS6 integrator complex subunit 6 0.0577679
AHNAK AHNAK nucleoprotein 0.0562449
CEMIP cell migration inducing protein, hyaluronan binding 0.0521327
AGO2 argonaute RISC catalytic component 2 0.0520108
LAMA4 laminin, alpha 4 0.0480744
ATF6 activating transcription factor 6 0.0474772
ENO1 enolase 1, (alpha) 0.0474439
TSC22D2 TSC22 domain family, member 2 0.0464625
MYH9 myosin, heavy chain 9, non-muscle 0.0433699
DSCAM Down syndrome cell adhesion molecule 0.0431124
SYAP1 synapse associated protein 1 0.041433
CPE carboxypeptidase E 0.0411665
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.039979
IRS2 insulin receptor substrate 2 0.0398548
MAP2K1 mitogen-activated protein kinase kinase 1 0.0397825
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0393614
HOMER1 homer scaffolding protein 1 0.0392712
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0389861
ANXA1 annexin A1 0.0388449
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387324
FNDC3A fibronectin type III domain containing 3A 0.0385002
DOCK5 dedicator of cytokinesis 5 0.0377346
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0374421
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0356644
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0352561
SAMD4A sterile alpha motif domain containing 4A 0.0345655
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0344405
AKAP12 A kinase (PRKA) anchor protein 12 0.0334051
PLEC plectin 0.033266
RNF149 ring finger protein 149 0.0332626
MACF1 microtubule-actin crosslinking factor 1 0.0328248
GCLC glutamate-cysteine ligase, catalytic subunit 0.0315296
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0298892
TES testin LIM domain protein 0.0293306
NPC1 Niemann-Pick disease, type C1 0.0280882
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0280502
GOLGB1 golgin B1 0.0280271
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0277325
MT2A metallothionein 2A 0.0274616
MYOF myoferlin 0.026448
CD163L1 CD163 molecule-like 1 0.0264268
SFPQ splicing factor proline/glutamine-rich 0.0257808
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0256655
BIRC3 baculoviral IAP repeat containing 3 0.0255666
ATP11A ATPase, class VI, type 11A 0.0252606
HDAC4 histone deacetylase 4 0.0251253
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0248947
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0246526
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.024599
RPSA2 ribosomal protein SA 2 0.0244979
PCBP2 poly(rC) binding protein 2 0.0242949
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.024169
JMJD1C jumonji domain containing 1C 0.0240991
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.023504
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.023325
LRP12 low density lipoprotein receptor-related protein 12 0.0233149
YAP1 Yes-associated protein 1 0.0232314
USP9X ubiquitin specific peptidase 9, X-linked 0.0230672
RPL3 ribosomal protein L3 0.0230548
BMP6 bone morphogenetic protein 6 0.0229771
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0229479
SIK3 SIK family kinase 3 0.0227607
BCL9L B-cell CLL/lymphoma 9-like 0.0226917
DIAPH1 diaphanous-related formin 1 0.0226114
JAK1 Janus kinase 1 0.0225383
EXOC6B exocyst complex component 6B 0.0225004
MOSMO modulator of smoothened 0.0224137
EIF4B eukaryotic translation initiation factor 4B 0.0220165
CCNH cyclin H 0.0219216
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0218972
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0218915
POTEF POTE ankyrin domain family, member F 0.0218852
HSPA8 heat shock 70kDa protein 8 0.021704
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0215842
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0214382
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.021354
ZC3H12B zinc finger CCCH-type containing 12B 0.0212642
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.021161
TMCO3 transmembrane and coiled-coil domains 3 0.021148
ACTG1 actin gamma 1 0.0209923
ANKRD11 ankyrin repeat domain 11 0.020732
HYOU1 hypoxia up-regulated 1 0.0206657
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0206183
STK24 serine/threonine kinase 24 0.0205875
EEF2 eukaryotic translation elongation factor 2 0.0205854
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0205643
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0205376
JARID2 jumonji, AT rich interactive domain 2 0.0201485

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.286941
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17646
NDRG1 N-myc downstream regulated 1 -0.123947
ASPH aspartate beta-hydroxylase -0.12123
EGFR epidermal growth factor receptor -0.090859
PTPRM protein tyrosine phosphatase, receptor type, M -0.0713984
TMSB10 thymosin beta 10 -0.0675445
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0536212
EGR1 early growth response 1 -0.0514926
NABP1 nucleic acid binding protein 1 -0.0505588
OSMR oncostatin M receptor -0.0488037
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0474711
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0473274
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0452603
CDCP1 CUB domain containing protein 1 -0.0442746
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0441326
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.044034
TPT1 tumor protein, translationally-controlled 1 -0.0431582
IGFBP3 insulin-like growth factor binding protein 3 -0.0431276
CAV1 caveolin 1, caveolae protein, 22kDa -0.0416197
ZMYND8 zinc finger, MYND-type containing 8 -0.0405234
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0404361
SOD2 superoxide dismutase 2, mitochondrial -0.0402607
HMGA1 high mobility group AT-hook 1 -0.0379716
PDLIM5 PDZ and LIM domain 5 -0.0374542
FNDC3B fibronectin type III domain containing 3B -0.0363018
H1-0 H1.0 linker histone -0.0351925
RAB27B RAB27B, member RAS oncogene family -0.0350826
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0350045
B2M beta-2-microglobulin -0.034225
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0329572
CCND1 cyclin D1 -0.0316085
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0315102
S100A10 S100 calcium binding protein A10 -0.0304581
MYO1D myosin ID -0.0297598
LRP1B low density lipoprotein receptor-related protein 1B -0.0291469
IER3 immediate early response 3 -0.0290891
RPL35A ribosomal protein L35a -0.0287894
PDE8A phosphodiesterase 8A -0.0287216
FTL ferritin, light polypeptide -0.0280822
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.027458
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0272488
FTH1 ferritin, heavy polypeptide 1 -0.0271198
PATJ PATJ crumbs cell polarity complex component -0.0271047
UGDH UDP-glucose 6-dehydrogenase -0.0269947
RAB7A RAB7A, member RAS oncogene family -0.0269085
PTMA prothymosin, alpha -0.026727
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0264478
RAP1B RAP1B, member of RAS oncogene family -0.0261594
GSK3B glycogen synthase kinase 3 beta -0.0260981
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0260192
PDIA3 protein disulfide isomerase family A, member 3 -0.0257284
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0254005
BTG1 B-cell translocation gene 1, anti-proliferative -0.0253772
RPS24 ribosomal protein S24 -0.025299
BIRC6 baculoviral IAP repeat containing 6 -0.0251947
TAS2R14 taste receptor, type 2, member 14 -0.0250484
TMEM165 transmembrane protein 165 -0.0249465
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.024935
AGR2 anterior gradient 2 -0.0247621
ANKRD10 ankyrin repeat domain 10 -0.0243733
CAPN2 calpain 2, (m/II) large subunit -0.0242237
GM2A GM2 ganglioside activator -0.0238094
RASA2 RAS p21 protein activator 2 -0.0237481
TRAF3 TNF receptor-associated factor 3 -0.0237361
ATG7 autophagy related 7 -0.0236574
EFNA5 ephrin-A5 -0.0234941
TNS3 tensin 3 -0.0234138
MCU mitochondrial calcium uniporter -0.0233956
EHBP1 EH domain binding protein 1 -0.0230035
RAB1A RAB1A, member RAS oncogene family -0.0225678
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0225291
MAML2 mastermind-like 2 (Drosophila) -0.0224684
RPS6 ribosomal protein S6 -0.0224382
SLMAP sarcolemma associated protein -0.0223016
RPS25 ribosomal protein S25 -0.0217532
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0216462
SLC38A1 solute carrier family 38, member 1 -0.0216082
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0215913
KRT8 keratin 8, type II -0.0213522
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0212936
VDAC1 voltage-dependent anion channel 1 -0.0212624
HLA-B major histocompatibility complex, class I, B -0.0211729
TRIO trio Rho guanine nucleotide exchange factor -0.0211667
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0211653
GNAS GNAS complex locus -0.0210826
RIN2 Ras and Rab interactor 2 -0.0210216
KMT2E lysine (K)-specific methyltransferase 2E -0.0206429
ARRDC3 arrestin domain containing 3 -0.0206064
NCOA7 nuclear receptor coactivator 7 -0.0205349
PDE4B phosphodiesterase 4B, cAMP-specific -0.020487
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0199522
SP100 SP100 nuclear antigen -0.0199294
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0198138
LIMCH1 LIM and calponin homology domains 1 -0.0197037
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0195763
CERT1 ceramide transporter 1 -0.0195283
NAMPT nicotinamide phosphoribosyltransferase -0.0193228
WSB1 WD repeat and SOCS box containing 1 -0.01909
EBF1 early B-cell factor 1 -0.0189797