Gallic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.157433
ZEB2 zinc finger E-box binding homeobox 2 0.121269
HIPK2 homeodomain interacting protein kinase 2 0.0835743
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0814553
FN1 fibronectin 1 0.071176
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0602579
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0598089
ANKRD28 ankyrin repeat domain 28 0.0493163
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0491279
SMAD3 SMAD family member 3 0.0450834
ADD3 adducin 3 (gamma) 0.0433772
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0425913
RUNX2 runt-related transcription factor 2 0.0417471
PELI1 pellino E3 ubiquitin protein ligase 1 0.0401966
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0397439
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0383505
NRP1 neuropilin 1 0.0377816
NTN4 netrin 4 0.036964
ARHGAP5 Rho GTPase activating protein 5 0.0368717
DST dystonin 0.0366518
AOPEP aminopeptidase O (putative) 0.0366218
SIK3 SIK family kinase 3 0.0357199
ELL2 elongation factor, RNA polymerase II, 2 0.0342985
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0299822
AHNAK AHNAK nucleoprotein 0.0297413
WWTR1 WW domain containing transcription regulator 1 0.0285577
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0284364
ITGAV integrin, alpha V 0.02831
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0281599
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0277267
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0273904
MACF1 microtubule-actin crosslinking factor 1 0.0272582
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0266746
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0263382
RAD51B RAD51 paralog B 0.0255163
RNF144A ring finger protein 144A 0.0251253
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.025002
DPYSL3 dihydropyrimidinase-like 3 0.0245019
IRAK2 interleukin-1 receptor-associated kinase 2 0.024453
VEGFA vascular endothelial growth factor A 0.0242815
RAB27B RAB27B, member RAS oncogene family 0.0239572
SYAP1 synapse associated protein 1 0.0234948
MAP1B microtubule-associated protein 1B 0.023316
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0223561
MCL1 myeloid cell leukemia 1 0.0223317
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0222733
ESYT2 extended synaptotagmin-like protein 2 0.0221418
EZR ezrin 0.02209
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0212755
GLCCI1 glucocorticoid induced 1 0.0212282
LAMA4 laminin, alpha 4 0.0210006
NPC1 Niemann-Pick disease, type C1 0.0209883
SPRED2 sprouty-related, EVH1 domain containing 2 0.0208602
IL1R1 interleukin 1 receptor, type I 0.0208476
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0207135
ANKH ANKH inorganic pyrophosphate transport regulator 0.0206118
SYNJ2 synaptojanin 2 0.0205305
HAS2 hyaluronan synthase 2 0.0204103
FKBP5 FK506 binding protein 5 0.020392
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0202221
RGS17 regulator of G-protein signaling 17 0.0201465
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0201055
STK38L serine/threonine kinase 38 like 0.0201036
PTPRM protein tyrosine phosphatase, receptor type, M 0.0200726
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0196472
EPS8 epidermal growth factor receptor pathway substrate 8 0.0195002
SVIL supervillin 0.0191057
CD58 CD58 molecule 0.018897
TMEM164 transmembrane protein 164 0.0188579
KIF13B kinesin family member 13B 0.0187223
MYH9 myosin, heavy chain 9, non-muscle 0.0186751
VEGFC vascular endothelial growth factor C 0.0186594
SPRED1 sprouty-related, EVH1 domain containing 1 0.0182722
FTH1 ferritin, heavy polypeptide 1 0.0182031
WLS wntless Wnt ligand secretion mediator 0.0180876
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.017906
ATP13A3 ATPase type 13A3 0.0177644
PRSS23 protease, serine, 23 0.0177335
TMEM163 transmembrane protein 163 0.017725
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0174893
RNF145 ring finger protein 145 0.0173791
FAM13A family with sequence similarity 13, member A 0.0172961
TENT5A terminal nucleotidyltransferase 5A 0.0172804
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0172028
DNMBP dynamin binding protein 0.0171888
SYT1 synaptotagmin I 0.0170801
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0169548
AFF1 AF4/FMR2 family, member 1 0.0166839
MLPH melanophilin 0.0164851
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0164719
FHL2 four and a half LIM domains 2 0.0162723
NCOR2 nuclear receptor corepressor 2 0.0161637
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0160454
AFDN afadin, adherens junction formation factor 0.0159972
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.0159496
C1D C1D nuclear receptor corepressor 0.0158625
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0155891
RHCG Rh family, C glycoprotein 0.0155315
CCDC68 coiled-coil domain containing 68 0.0152234
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0151854

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.265603
VIM vimentin -0.162137
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15397
PDE4D phosphodiesterase 4D, cAMP-specific -0.140247
SDK1 sidekick cell adhesion molecule 1 -0.135742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.128514
NRG1 neuregulin 1 -0.119444
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.111422
STC1 stanniocalcin 1 -0.111001
CDH13 cadherin 13 -0.110006
TMSB10 thymosin beta 10 -0.108336
IGFBP3 insulin-like growth factor binding protein 3 -0.106242
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0982972
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0978292
MTSS1 metastasis suppressor 1 -0.0859717
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0792125
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0786086
TFPI2 tissue factor pathway inhibitor 2 -0.0730749
UBC ubiquitin C -0.0662691
USP34 ubiquitin specific peptidase 34 -0.0603005
PTMA prothymosin, alpha -0.0593513
NCOA7 nuclear receptor coactivator 7 -0.0565064
RAB1A RAB1A, member RAS oncogene family -0.050986
NDRG1 N-myc downstream regulated 1 -0.0468718
MT2A metallothionein 2A -0.0464503
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0463774
GOLGA4 golgin A4 -0.0457635
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0454645
HDLBP high density lipoprotein binding protein -0.0453941
SEC31A SEC31 homolog A (S. cerevisiae) -0.0445304
ATG7 autophagy related 7 -0.0442398
IER3 immediate early response 3 -0.0442273
FRMD4A FERM domain containing 4A -0.0442061
TPT1 tumor protein, translationally-controlled 1 -0.0441142
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0430291
PDIA3 protein disulfide isomerase family A, member 3 -0.042537
EFNA5 ephrin-A5 -0.0421787
FNDC3B fibronectin type III domain containing 3B -0.0420744
TAS2R14 taste receptor, type 2, member 14 -0.0415127
RPS8 ribosomal protein S8 -0.0415121
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.041483
EIF1 eukaryotic translation initiation factor 1 -0.0413287
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0413066
DPYD dihydropyrimidine dehydrogenase -0.0405148
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0404124
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.039664
EFCAB13 EF-hand calcium binding domain 13 -0.0396288
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0396231
BTG1 B-cell translocation gene 1, anti-proliferative -0.0396171
NAP1L1 nucleosome assembly protein 1-like 1 -0.0391133
SOD2 superoxide dismutase 2, mitochondrial -0.0391074
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0385746
RPLP1 ribosomal protein, large, P1 -0.0380809
CANX calnexin -0.0378418
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0375206
CALU calumenin -0.0368798
DLG1 discs, large homolog 1 (Drosophila) -0.0364852
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0363873
MSRB3 methionine sulfoxide reductase B3 -0.0363744
RPL23 ribosomal protein L23 -0.0363511
MAML3 mastermind-like 3 (Drosophila) -0.0360206
TMEM263 transmembrane protein 263 -0.0359474
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0357848
RPL31 ribosomal protein L31 -0.0357524
RAP1B RAP1B, member of RAS oncogene family -0.0356117
RPS24 ribosomal protein S24 -0.035546
CDK14 cyclin-dependent kinase 14 -0.0354708
RPS6 ribosomal protein S6 -0.0352908
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0351348
TM4SF1 transmembrane 4 L six family member 1 -0.0342775
EGFR epidermal growth factor receptor -0.0340447
RPS12 ribosomal protein S12 -0.0338557
ZNF804A zinc finger protein 804A -0.0335567
IFI6 interferon, alpha-inducible protein 6 -0.0331002
B2M beta-2-microglobulin -0.0329977
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0326859
SP100 SP100 nuclear antigen -0.0325958
DIAPH2 diaphanous-related formin 2 -0.0319201
ZSWIM6 zinc finger, SWIM-type containing 6 -0.031847
RPS19 ribosomal protein S19 -0.0318169
PKM pyruvate kinase, muscle -0.0316605
NAV3 neuron navigator 3 -0.0316467
DNER delta/notch-like EGF repeat containing -0.0315769
HM13 histocompatibility (minor) 13 -0.0307748
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0307483
NLK nemo-like kinase -0.0306963
NUMB numb homolog (Drosophila) -0.0306458
RPL34 ribosomal protein L34 -0.030556
EXT1 exostosin glycosyltransferase 1 -0.0300079
RPS25 ribosomal protein S25 -0.0295501
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0293768
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0293699
LMAN1 lectin, mannose-binding, 1 -0.0292667
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0292031
RPL12 ribosomal protein L12 -0.0290817
GPC6 glypican 6 -0.0288161
TRPS1 trichorhinophalangeal syndrome I -0.0287549
TMSB4X thymosin beta 4, X-linked -0.0286889
GNAS GNAS complex locus -0.0283372
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0282372