Gallic acid_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.201408
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.13529
LAMB3 laminin, beta 3 0.126359
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.114904
BACE2 beta-site APP-cleaving enzyme 2 0.110891
AHNAK AHNAK nucleoprotein 0.0996497
IGF2 insulin-like growth factor 2 0.090542
OGA O-GlcNAcase 0.0897219
ERRFI1 ERBB receptor feedback inhibitor 1 0.0776586
TXNRD1 thioredoxin reductase 1 0.0736436
AKAP9 A kinase (PRKA) anchor protein 9 0.0701584
JMJD1C jumonji domain containing 1C 0.0647272
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0643038
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0628315
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0623709
KMT2C lysine (K)-specific methyltransferase 2C 0.061332
EGFR epidermal growth factor receptor 0.0603815
ATXN1 ataxin 1 0.05923
CTBP2 C-terminal binding protein 2 0.0589462
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0586254
ATP11A ATPase, class VI, type 11A 0.0516009
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0476139
C3 complement component 3 0.0469873
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0465988
NAV2 neuron navigator 2 0.0453828
USP9X ubiquitin specific peptidase 9, X-linked 0.0451464
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0449436
ZNF638 zinc finger protein 638 0.0447259
DOCK4 dedicator of cytokinesis 4 0.0441788
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0440636
ZEB1 zinc finger E-box binding homeobox 1 0.0439368
F3 coagulation factor III (thromboplastin, tissue factor) 0.0435182
FMNL2 formin-like 2 0.0434962
FLNB filamin B, beta 0.0418911
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0416131
TXNIP thioredoxin interacting protein 0.0414839
YAP1 Yes-associated protein 1 0.041394
MYO5B myosin VB 0.0409077
TM9SF3 transmembrane 9 superfamily member 3 0.0406247
LPP LIM domain containing preferred translocation partner in lipoma 0.0403485
SMYD3 SET and MYND domain containing 3 0.0401699
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.040159
NAP1L1 nucleosome assembly protein 1-like 1 0.0399619
DIAPH2 diaphanous-related formin 2 0.0388418
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0382527
CMIP c-Maf inducing protein 0.0381457
UGCG UDP-glucose ceramide glucosyltransferase 0.0379164
UBE2H ubiquitin-conjugating enzyme E2H 0.0374576
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0370973
PFKP phosphofructokinase, platelet 0.0369272
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0369079
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0367745
STC1 stanniocalcin 1 0.0367376
BRWD1 bromodomain and WD repeat domain containing 1 0.0366657
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0362322
IGF1R insulin-like growth factor 1 receptor 0.0360571
OSBPL8 oxysterol binding protein-like 8 0.0359708
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0358021
NDRG1 N-myc downstream regulated 1 0.0352102
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0348254
EPN2 epsin 2 0.0348055
FAM13A family with sequence similarity 13, member A 0.0346285
PRKCE protein kinase C, epsilon 0.0346157
SRI sorcin 0.0342852
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0342361
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0340524
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0339688
EML4 echinoderm microtubule associated protein like 4 0.0337205
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0336633
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0335203
CHD1 chromodomain helicase DNA binding protein 1 0.0333866
LDHA lactate dehydrogenase A 0.033281
KIF13A kinesin family member 13A 0.0331731
ZCCHC7 zinc finger, CCHC domain containing 7 0.0328498
MARCHF7 membrane associated ring-CH-type finger 7 0.0328453
GDI2 GDP dissociation inhibitor 2 0.0326101
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0325259
EIF1 eukaryotic translation initiation factor 1 0.0321733
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0320747
SNX14 sorting nexin 14 0.0318094
VCL vinculin 0.0317195
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0315563
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0314571
SFTPA2 surfactant protein A2 0.0312012
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0310055
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0309418
FBF1 Fas (TNFRSF6) binding factor 1 0.0309335
RESF1 retroelement silencing factor 1 0.0307205
BZW1 basic leucine zipper and W2 domains 1 0.0305455
HSPH1 heat shock 105kDa/110kDa protein 1 0.0302473
PCBP2 poly(rC) binding protein 2 0.0302404
ENO1 enolase 1, (alpha) 0.0302054
GLG1 golgi glycoprotein 1 0.0299657
DUSP4 dual specificity phosphatase 4 0.0297518
TNRC6A trinucleotide repeat containing 6A 0.0297352
CFDP1 craniofacial development protein 1 0.0296992
PHF3 PHD finger protein 3 0.0296945
KPNB1 karyopherin (importin) beta 1 0.02964
PHF21A PHD finger protein 21A 0.0296248
ZDHHC20 zinc finger, DHHC-type containing 20 0.0295859

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133735
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.127452
GRB10 growth factor receptor-bound protein 10 -0.103953
KYNU kynureninase -0.0882806
ANXA2 annexin A2 -0.0732954
SDC4 syndecan 4 -0.0694927
ATOSA atos homolog A -0.0659308
STAU1 staufen double-stranded RNA binding protein 1 -0.0611584
FNDC3B fibronectin type III domain containing 3B -0.0608413
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0607107
MUC16 mucin 16, cell surface associated -0.0573164
LOC112694756 uncharaterized LOC112694756 -0.0564869
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0548351
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0541953
MYO1E myosin IE -0.0538076
INTS6 integrator complex subunit 6 -0.0535278
LAMC2 laminin, gamma 2 -0.0523818
KDM2A lysine (K)-specific demethylase 2A -0.0518602
MACC1 metastasis associated in colon cancer 1 -0.0517968
PRRC2C proline-rich coiled-coil 2C -0.0516766
ASPH aspartate beta-hydroxylase -0.0515883
TOP1 topoisomerase (DNA) I -0.0514017
KIF13B kinesin family member 13B -0.0494168
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.048158
VMP1 vacuole membrane protein 1 -0.0479459
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0478735
FTH1 ferritin, heavy polypeptide 1 -0.0469772
ADNP activity-dependent neuroprotector homeobox -0.0469591
BIRC6 baculoviral IAP repeat containing 6 -0.0461832
SVIL supervillin -0.0461501
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0457111
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.045552
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0450392
ARF1 ADP-ribosylation factor 1 -0.0449636
SAMD4A sterile alpha motif domain containing 4A -0.044708
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0444828
CSNK1A1 casein kinase 1, alpha 1 -0.0441043
OSMR oncostatin M receptor -0.0427245
GSK3B glycogen synthase kinase 3 beta -0.0422359
FTL ferritin, light polypeptide -0.0422309
CD2AP CD2-associated protein -0.0421519
MCL1 myeloid cell leukemia 1 -0.0416081
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0415523
SPNS2 spinster homolog 2 (Drosophila) -0.0414476
MATR3 matrin 3 -0.0408675
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0408038
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0405455
TMEM165 transmembrane protein 165 -0.0403201
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0401306
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0396242
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0394973
AKAP13 A kinase (PRKA) anchor protein 13 -0.0393415
ANKRD36C ankyrin repeat domain 36C -0.0392006
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0390372
RPL35A ribosomal protein L35a -0.0382577
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0377789
CYRIB CYFIP related Rac1 interactor B -0.0377595
NALF1 NALCN channel auxiliary factor 1 -0.0377432
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0377093
PTK2 protein tyrosine kinase 2 -0.037559
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0374762
SSH2 slingshot protein phosphatase 2 -0.0374396
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0369795
RORA RAR-related orphan receptor A -0.0368379
TRPS1 trichorhinophalangeal syndrome I -0.0365831
CDH13 cadherin 13 -0.0363317
CLTC clathrin, heavy chain (Hc) -0.0363138
MYO6 myosin VI -0.0361839
AFF1 AF4/FMR2 family, member 1 -0.0354052
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0350205
IFIH1 interferon induced with helicase C domain 1 -0.0347983
ZMYND8 zinc finger, MYND-type containing 8 -0.0342785
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0337266
RBM47 RNA binding motif protein 47 -0.0334897
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0333078
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0330786
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0327814
SEC24A SEC24 family member A -0.0326641
TENT5A terminal nucleotidyltransferase 5A -0.0325052
USP53 ubiquitin specific peptidase 53 -0.0323302
UBAP1 ubiquitin associated protein 1 -0.0323191
GOLGB1 golgin B1 -0.0320557
CAPN2 calpain 2, (m/II) large subunit -0.031962
NCOA3 nuclear receptor coactivator 3 -0.0319553
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0319548
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0317238
RCOR1 REST corepressor 1 -0.0316947
USP8 ubiquitin specific peptidase 8 -0.0316737
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0312321
PIBF1 progesterone immunomodulatory binding factor 1 -0.0311654
SEC31A SEC31 homolog A (S. cerevisiae) -0.0311225
DSCAM Down syndrome cell adhesion molecule -0.0308705
PLSCR1 phospholipid scramblase 1 -0.0305281
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.030485
SOX4 SRY (sex determining region Y)-box 4 -0.0304368
CYTH1 cytohesin 1 -0.0303952
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0301048
RAI14 retinoic acid induced 14 -0.0296604
SETX senataxin -0.0296192
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0295706