Gallic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.328213
ACTG1 actin gamma 1 0.162039
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.161163
ENO1 enolase 1, (alpha) 0.126342
MYH9 myosin, heavy chain 9, non-muscle 0.120533
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112839
AHNAK AHNAK nucleoprotein 0.0921045
EFNA5 ephrin-A5 0.087243
APLP2 amyloid beta (A4) precursor-like protein 2 0.083798
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0812208
SAMD4A sterile alpha motif domain containing 4A 0.0794511
ERRFI1 ERBB receptor feedback inhibitor 1 0.074343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0738394
DSPP dentin sialophosphoprotein 0.0675835
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0660402
EEF2 eukaryotic translation elongation factor 2 0.0647972
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0645637
PCBP2 poly(rC) binding protein 2 0.062241
MSN moesin 0.0608787
TPM3 tropomyosin 3 0.0594637
NAV2 neuron navigator 2 0.0592238
VEGFA vascular endothelial growth factor A 0.0554307
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0544777
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0539007
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0515137
PLEC plectin 0.0511787
RPL3 ribosomal protein L3 0.0508277
MCL1 myeloid cell leukemia 1 0.0500126
HSPA8 heat shock 70kDa protein 8 0.0492834
LAMC2 laminin, gamma 2 0.0468888
LDHA lactate dehydrogenase A 0.0468155
ENO2 enolase 2 (gamma, neuronal) 0.0453184
ASPH aspartate beta-hydroxylase 0.0431651
CALR calreticulin 0.0429554
ARRDC3 arrestin domain containing 3 0.0427681
NDRG1 N-myc downstream regulated 1 0.0427167
TXNIP thioredoxin interacting protein 0.0420522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0413648
AKAP13 A kinase (PRKA) anchor protein 13 0.0404979
CTSB cathepsin B 0.0399699
FTH1 ferritin, heavy polypeptide 1 0.0385884
RPL4 ribosomal protein L4 0.0383044
ELL2 elongation factor, RNA polymerase II, 2 0.0376996
RPS12 ribosomal protein S12 0.0375835
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0367387
MYO5B myosin VB 0.0357591
DIAPH1 diaphanous-related formin 1 0.035467
EIF4B eukaryotic translation initiation factor 4B 0.033836
PKM pyruvate kinase, muscle 0.0335304
EIF4A1 eukaryotic translation initiation factor 4A1 0.0326859
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0326375
TACSTD2 tumor-associated calcium signal transducer 2 0.0322425
MACF1 microtubule-actin crosslinking factor 1 0.0320416
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0314687
RPS3 ribosomal protein S3 0.0309377
ANO6 anoctamin 6 0.030455
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0295832
APP amyloid beta (A4) precursor protein 0.0289381
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0289269
NOTCH2 notch 2 0.028471
SDC4 syndecan 4 0.0282704
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0282305
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0279706
FHIT fragile histidine triad 0.0278574
PGBD5 piggyBac transposable element derived 5 0.0274692
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0271009
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0269612
LAMB3 laminin, beta 3 0.0268738
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0264699
BRD2 bromodomain containing 2 0.0263388
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0261911
TRIO trio Rho guanine nucleotide exchange factor 0.025473
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0254526
RAD51B RAD51 paralog B 0.0252081
VGLL3 vestigial-like family member 3 0.0251059
MCTP2 multiple C2 domains, transmembrane 2 0.0250116
AHNAK2 AHNAK nucleoprotein 2 0.0248636
RALB v-ral simian leukemia viral oncogene homolog B 0.0243915
ADAM9 ADAM metallopeptidase domain 9 0.0240413
EIF5 eukaryotic translation initiation factor 5 0.023803
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0235957
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0234152
DOCK5 dedicator of cytokinesis 5 0.0231437
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022773
YAP1 Yes-associated protein 1 0.0226454
IGFBP3 insulin-like growth factor binding protein 3 0.0224908
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222371
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0221527
SET SET nuclear proto-oncogene 0.0220734
MAP1B microtubule-associated protein 1B 0.0219397
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.02183
MX1 MX dynamin-like GTPase 1 0.0217271
BCL2L1 BCL2-like 1 0.0216877
PPARD peroxisome proliferator-activated receptor delta 0.0215163
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0212918
HDGF hepatoma-derived growth factor 0.0212068
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0211345
YBX1 Y box binding protein 1 0.0208385
KDM6A lysine (K)-specific demethylase 6A 0.0208024
ADAR adenosine deaminase, RNA-specific 0.0203779

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116227
TPT1 tumor protein, translationally-controlled 1 -0.106124
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.092077
TMSB10 thymosin beta 10 -0.0810467
FN1 fibronectin 1 -0.0802116
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0793042
ALCAM activated leukocyte cell adhesion molecule -0.0750616
GNAS GNAS complex locus -0.0736177
S100A6 S100 calcium binding protein A6 -0.0732486
RPL35A ribosomal protein L35a -0.0717682
RPL34 ribosomal protein L34 -0.064362
PTMA prothymosin, alpha -0.063267
NPEPPS aminopeptidase puromycin sensitive -0.0623435
S100A10 S100 calcium binding protein A10 -0.0616494
WSB1 WD repeat and SOCS box containing 1 -0.060642
TMEM263 transmembrane protein 263 -0.0556693
TM4SF1 transmembrane 4 L six family member 1 -0.0546843
RAB1A RAB1A, member RAS oncogene family -0.0528861
KDM5B lysine (K)-specific demethylase 5B -0.0518676
CCND1 cyclin D1 -0.0514359
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0508186
MARCHF6 membrane associated ring-CH-type finger 6 -0.0506811
RAB7A RAB7A, member RAS oncogene family -0.0496493
KMT2E lysine (K)-specific methyltransferase 2E -0.0452439
SEC31A SEC31 homolog A (S. cerevisiae) -0.0447724
RAD21 RAD21 homolog (S. pombe) -0.0443405
ARF1 ADP-ribosylation factor 1 -0.0441695
HMGA1 high mobility group AT-hook 1 -0.0440251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0429272
CD2AP CD2-associated protein -0.0413529
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.040562
RRBP1 ribosome binding protein 1 -0.040421
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0400416
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0397314
KDM3A lysine (K)-specific demethylase 3A -0.039338
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0383601
ACBD3 acyl-CoA binding domain containing 3 -0.0380301
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0379608
RPS6 ribosomal protein S6 -0.0372099
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0370043
SPAG9 sperm associated antigen 9 -0.0369277
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0368505
BLZF1 basic leucine zipper nuclear factor 1 -0.0363394
SLC38A1 solute carrier family 38, member 1 -0.0361752
TMEM123 transmembrane protein 123 -0.0361204
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.035996
RPS24 ribosomal protein S24 -0.0356489
ZNF292 zinc finger protein 292 -0.0352579
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0349745
FNDC3B fibronectin type III domain containing 3B -0.0343615
GOLGA4 golgin A4 -0.033397
LMAN1 lectin, mannose-binding, 1 -0.0333778
SQSTM1 sequestosome 1 -0.0329172
TFG TRK-fused gene -0.032439
OSBPL3 oxysterol binding protein-like 3 -0.0319815
TRA2A transformer 2 alpha homolog (Drosophila) -0.0317159
PDLIM5 PDZ and LIM domain 5 -0.0316926
LMNA lamin A/C -0.0315864
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0315305
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0315214
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0314184
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313265
SEC24D SEC24 family member D -0.0309019
CAVIN1 caveolae associated protein 1 -0.0308721
WASF2 WAS protein family, member 2 -0.0308637
RLF rearranged L-myc fusion -0.030846
IFI16 interferon, gamma-inducible protein 16 -0.0308071
ZFAND3 zinc finger, AN1-type domain 3 -0.0303126
CTSD cathepsin D -0.0297523
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.029687
RPL8 ribosomal protein L8 -0.0296655
CCNI cyclin I -0.0290552
VCL vinculin -0.0288858
H3-3B H3.3 histone B -0.0287595
CALU calumenin -0.0284969
CERT1 ceramide transporter 1 -0.0284618
LY6E lymphocyte antigen 6 complex, locus E -0.0279066
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0278688
FBXO34 F-box protein 34 -0.0277606
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0277279
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0272328
MON2 MON2 homolog (S. cerevisiae) -0.0272062
RPL32 ribosomal protein L32 -0.0265805
RPLP0 ribosomal protein, large, P0 -0.0265689
PRRC1 proline-rich coiled-coil 1 -0.0264439
GPBP1 GC-rich promoter binding protein 1 -0.0264426
FBXO11 F-box protein 11 -0.0262416
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0261212
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0259219
CEP350 centrosomal protein 350kDa -0.0258952
CANX calnexin -0.0258297
TSC22D2 TSC22 domain family, member 2 -0.0255906
SLMAP sarcolemma associated protein -0.0255638
NAP1L1 nucleosome assembly protein 1-like 1 -0.0255304
RBM39 RNA binding motif protein 39 -0.0253017
MXD1 MAX dimerization protein 1 -0.0248494
TKT transketolase -0.024601
IFRD1 interferon-related developmental regulator 1 -0.0238825
FAM162A family with sequence similarity 162, member A -0.0237976
CRABP2 cellular retinoic acid binding protein 2 -0.0237834