Gallic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NTM neurotrimin 0.070757
ANK2 ankyrin 2, neuronal 0.0658549
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.060013
FOXP2 forkhead box P2 0.0436246
THBS1 thrombospondin 1 0.0420247
COL5A2 collagen, type V, alpha 2 0.0413416
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0390389
AHNAK AHNAK nucleoprotein 0.0334235
DST dystonin 0.0302088
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0296262
RPL3 ribosomal protein L3 0.0294665
BLTP1 bridge-like lipid transfer protein family member 1 0.0290305
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.028224
UBN2 ubinuclein 2 0.0278343
MACF1 microtubule-actin crosslinking factor 1 0.0259008
EIF4B eukaryotic translation initiation factor 4B 0.0258146
EEF2 eukaryotic translation elongation factor 2 0.0250743
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0250367
APLP2 amyloid beta (A4) precursor-like protein 2 0.024846
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0246907
TTC28 tetratricopeptide repeat domain 28 0.0244607
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.024351
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242912
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0241486
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.022927
SMYD3 SET and MYND domain containing 3 0.0223359
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0222936
APP amyloid beta (A4) precursor protein 0.0212989
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0202389
ZNF608 zinc finger protein 608 0.0201488
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0197478
FAT1 FAT atypical cadherin 1 0.0195189
GPC3 glypican 3 0.0192738
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0192478
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0191825
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0188714
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0185526
RREB1 ras responsive element binding protein 1 0.0179524
ZC3H12B zinc finger CCCH-type containing 12B 0.0177728
TNRC6A trinucleotide repeat containing 6A 0.0176225
ANKRD36 ankyrin repeat domain 36 0.017599
MBOAT1 membrane bound O-acyltransferase domain containing 1 0.017323
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0172858
PDZRN4 PDZ domain containing ring finger 4 0.0170979
NHSL1 NHS-like 1 0.0169295
VMP1 vacuole membrane protein 1 0.016747
HYOU1 hypoxia up-regulated 1 0.0165486
USP9X ubiquitin specific peptidase 9, X-linked 0.0164874
ARL15 ADP-ribosylation factor-like 15 0.0163328
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0161297
CDH19 cadherin 19, type 2 0.0160673
AFF1 AF4/FMR2 family, member 1 0.0159605
MIPOL1 mirror-image polydactyly 1 0.015874
GREB1L growth regulation by estrogen in breast cancer-like 0.0158573
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0158489
GASK1B golgi associated kinase 1B 0.0155172
MYH10 myosin, heavy chain 10, non-muscle 0.0153293
CCNG2 cyclin G2 0.0153246
NKD1 naked cuticle homolog 1 (Drosophila) 0.0152712
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0152269
PTK7 protein tyrosine kinase 7 (inactive) 0.0151815
SNX13 sorting nexin 13 0.0151591
RBM20 RNA binding motif protein 20 0.0151178
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0151178
ATF7 activating transcription factor 7 0.0150802
HDAC9 histone deacetylase 9 0.014861
PCDH18 protocadherin 18 0.0147588
PDLIM5 PDZ and LIM domain 5 0.0140299
TSC22D1 TSC22 domain family, member 1 0.0139904
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0139577
TNRC18 trinucleotide repeat containing 18 0.0138555
PCDH11Y protocadherin 11 Y-linked 0.0138436
LRP6 low density lipoprotein receptor-related protein 6 0.0138206
TMEM120B transmembrane protein 120B 0.0137789
CLCN3 chloride channel, voltage-sensitive 3 0.0137527
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0137442
SPAG16 sperm associated antigen 16 0.0136353
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0134087
GLI3 GLI family zinc finger 3 0.013402
RIMS2 regulating synaptic membrane exocytosis 2 0.0132976
MBNL2 muscleblind-like splicing regulator 2 0.0132963
GTDC1 glycosyltransferase-like domain containing 1 0.0132399
USP22 ubiquitin specific peptidase 22 0.0129809
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.012973
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0128883
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0128143
EMC1 ER membrane protein complex subunit 1 0.0128119
PBX3 pre-B-cell leukemia homeobox 3 0.0126866
HABP4 hyaluronan binding protein 4 0.0126682
DSTYK dual serine/threonine and tyrosine protein kinase 0.0125001
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0124865
RPL4 ribosomal protein L4 0.012398
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0123355
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0122745
CADM1 cell adhesion molecule 1 0.0122689
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0122681
LDHA lactate dehydrogenase A 0.0121134
ZNF91 zinc finger protein 91 0.0120498
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0119389
BTBD10 BTB (POZ) domain containing 10 0.0119019

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.302763
TMSB10 thymosin beta 10 -0.127505
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10357
GNAS GNAS complex locus -0.103386
RPS6 ribosomal protein S6 -0.100901
CDH10 cadherin 10, type 2 (T2-cadherin) -0.100191
PEG10 paternally expressed 10 -0.0998937
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0994852
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0904649
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0846328
TPT1 tumor protein, translationally-controlled 1 -0.0840861
COL1A2 collagen, type I, alpha 2 -0.083433
PCDH9 protocadherin 9 -0.0826111
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0732094
PTMA prothymosin, alpha -0.0699479
CADM2 cell adhesion molecule 2 -0.0674363
H1-0 H1.0 linker histone -0.0667773
RPS16 ribosomal protein S16 -0.0644338
MDK midkine (neurite growth-promoting factor 2) -0.062715
SLC38A2 solute carrier family 38, member 2 -0.0617316
ADGRL2 adhesion G protein-coupled receptor L2 -0.0596072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0590894
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0574122
PHIP pleckstrin homology domain interacting protein -0.056432
RPL35A ribosomal protein L35a -0.0561909
EMP1 epithelial membrane protein 1 -0.0553504
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0552057
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0544047
ANKRD12 ankyrin repeat domain 12 -0.0539665
PFN1 profilin 1 -0.0537054
MYL12B myosin, light chain 12B, regulatory -0.0533582
PCLO piccolo presynaptic cytomatrix protein -0.0532731
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0528936
RPLP0 ribosomal protein, large, P0 -0.0524673
TRIO trio Rho guanine nucleotide exchange factor -0.0515515
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0507817
NIPBL Nipped-B homolog (Drosophila) -0.0498577
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.049853
RAD21 RAD21 homolog (S. pombe) -0.0498278
RPS8 ribosomal protein S8 -0.0494728
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0490605
ACTG1 actin gamma 1 -0.0488272
SEPTIN7 septin 7 -0.0472511
RPL5 ribosomal protein L5 -0.0472364
FNDC3B fibronectin type III domain containing 3B -0.0470605
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0470296
NRG1 neuregulin 1 -0.0460635
ZNF292 zinc finger protein 292 -0.0458223
ATP5F1B ATP synthase F1 subunit beta -0.0450913
SFRP4 secreted frizzled-related protein 4 -0.0445982
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0437937
WSB1 WD repeat and SOCS box containing 1 -0.0427136
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0412832
RPL34 ribosomal protein L34 -0.0410999
KDM3A lysine (K)-specific demethylase 3A -0.0405541
NACA nascent polypeptide-associated complex alpha subunit -0.040147
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0400851
MRPS30 mitochondrial ribosomal protein S30 -0.0399192
TMSB4X thymosin beta 4, X-linked -0.039137
HMGB1 high mobility group box 1 -0.0390456
RASAL2 RAS protein activator like 2 -0.0388219
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.038522
S100A10 S100 calcium binding protein A10 -0.0383082
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0375574
RDX radixin -0.0372789
SPTSSA serine palmitoyltransferase, small subunit A -0.0370469
ZNF217 zinc finger protein 217 -0.036786
RPS21 ribosomal protein S21 -0.0366332
TUBA1B tubulin, alpha 1b -0.0365229
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0364914
PGAP1 post-GPI attachment to proteins 1 -0.036491
MPG N-methylpurine-DNA glycosylase -0.0364407
SETD5 SET domain containing 5 -0.0363932
PUM1 pumilio RNA-binding family member 1 -0.0361298
MAP4 microtubule-associated protein 4 -0.035779
CNRIP1 cannabinoid receptor interacting protein 1 -0.0357441
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0355971
STRN3 striatin, calmodulin binding protein 3 -0.0352951
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0348848
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0348782
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0348007
RPS13 ribosomal protein S13 -0.0343739
ANXA1 annexin A1 -0.034219
COL11A1 collagen, type XI, alpha 1 -0.0341588
CBX3 chromobox homolog 3 -0.0341194
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0341178
CAVIN1 caveolae associated protein 1 -0.0340001
CLTC clathrin, heavy chain (Hc) -0.0337478
RPLP1 ribosomal protein, large, P1 -0.0335303
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0335185
RAI1 retinoic acid induced 1 -0.0334562
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0334531
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0332709
SOX2 SRY (sex determining region Y)-box 2 -0.0330843
DEK DEK proto-oncogene -0.0327979
EIF1 eukaryotic translation initiation factor 1 -0.0323482
RPL23 ribosomal protein L23 -0.0319806
RPL19 ribosomal protein L19 -0.03194
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0318339
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0317396