Gallic acid_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FBL fibrillarin 0.193416
AHNAK AHNAK nucleoprotein 0.1456
PABPC1 poly(A) binding protein, cytoplasmic 1 0.10757
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.102041
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0912373
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0889699
MYH9 myosin, heavy chain 9, non-muscle 0.0844492
SMAD3 SMAD family member 3 0.0764037
AKAP12 A kinase (PRKA) anchor protein 12 0.0758988
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.065266
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0639879
WWTR1 WW domain containing transcription regulator 1 0.0628136
ERRFI1 ERBB receptor feedback inhibitor 1 0.0625095
APLP2 amyloid beta (A4) precursor-like protein 2 0.0612119
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0591079
PCBP2 poly(rC) binding protein 2 0.0569292
ENO1 enolase 1, (alpha) 0.0540768
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0534413
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0507727
IPO7 importin 7 0.0500096
YAP1 Yes-associated protein 1 0.0495785
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0489754
TXNRD1 thioredoxin reductase 1 0.048883
SFTPA2 surfactant protein A2 0.0480221
YBX1 Y box binding protein 1 0.0441734
EIF4B eukaryotic translation initiation factor 4B 0.0440058
ARRDC3 arrestin domain containing 3 0.0425341
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0418138
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0416884
EEF2 eukaryotic translation elongation factor 2 0.0406869
KTN1 kinectin 1 (kinesin receptor) 0.040504
JMJD1C jumonji domain containing 1C 0.0403703
FNDC3B fibronectin type III domain containing 3B 0.0393017
TPM3 tropomyosin 3 0.0391922
BIRC3 baculoviral IAP repeat containing 3 0.0388786
ANKRD11 ankyrin repeat domain 11 0.0388343
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0387493
OGA O-GlcNAcase 0.0385551
RPL3 ribosomal protein L3 0.0383303
APP amyloid beta (A4) precursor protein 0.038087
MACF1 microtubule-actin crosslinking factor 1 0.0378017
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0377061
SPTBN1 spectrin, beta, non-erythrocytic 1 0.036911
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0358727
ANXA2 annexin A2 0.0354381
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.035411
NFE2L1 nuclear factor, erythroid 2-like 1 0.0351251
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0350947
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0350611
ELL2 elongation factor, RNA polymerase II, 2 0.0346258
RPL4 ribosomal protein L4 0.0345009
ATP13A3 ATPase type 13A3 0.0341215
HSPA8 heat shock 70kDa protein 8 0.0334544
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0333024
SRRM2 serine/arginine repetitive matrix 2 0.0332053
BIRC2 baculoviral IAP repeat containing 2 0.0328873
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0328285
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.032192
MKI67 marker of proliferation Ki-67 0.0318258
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0317567
CENPF centromere protein F, 350/400kDa 0.0316487
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0313455
PLEC plectin 0.031288
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0304256
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0301722
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0301475
SET SET nuclear proto-oncogene 0.029798
AFDN afadin, adherens junction formation factor 0.0295984
DGKD diacylglycerol kinase, delta 130kDa 0.029317
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0292256
PTEN phosphatase and tensin homolog 0.0292252
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0291871
MSN moesin 0.029001
MYOF myoferlin 0.0288631
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.028641
ANO6 anoctamin 6 0.028437
IRAK2 interleukin-1 receptor-associated kinase 2 0.0282692
NT5E 5'-nucleotidase, ecto (CD73) 0.0274092
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0270847
CD44 CD44 molecule (Indian blood group) 0.0268332
FAT1 FAT atypical cadherin 1 0.0267075
KDM2A lysine (K)-specific demethylase 2A 0.0265631
XPO1 exportin 1 0.0264476
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0262436
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0260811
PGK1 phosphoglycerate kinase 1 0.0259574
LDHA lactate dehydrogenase A 0.0259408
FTH1 ferritin, heavy polypeptide 1 0.0258588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0257672
ITGAV integrin, alpha V 0.0256044
CKAP5 cytoskeleton associated protein 5 0.0252716
ASPH aspartate beta-hydroxylase 0.0251628
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0249871
PDIA3 protein disulfide isomerase family A, member 3 0.0249626
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0246657
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0243916
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0242572
USP9X ubiquitin specific peptidase 9, X-linked 0.0240646
HLTF helicase-like transcription factor 0.0238954
SFPQ splicing factor proline/glutamine-rich 0.0238802

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.232917
RPS16 ribosomal protein S16 -0.179783
EGR1 early growth response 1 -0.103022
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0971228
SLC35F3 solute carrier family 35, member F3 -0.0918131
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0888813
VIM vimentin -0.0880724
TMSB10 thymosin beta 10 -0.0845075
THSD4 thrombospondin, type I, domain containing 4 -0.0741548
RPS24 ribosomal protein S24 -0.0717847
RPL35A ribosomal protein L35a -0.0588359
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.056905
HSPG2 heparan sulfate proteoglycan 2 -0.0445581
ATG7 autophagy related 7 -0.0418242
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0399407
MYO1E myosin IE -0.0395683
SDK1 sidekick cell adhesion molecule 1 -0.0371085
CARD18 caspase recruitment domain family, member 18 -0.0369284
TPT1 tumor protein, translationally-controlled 1 -0.0360411
MT2A metallothionein 2A -0.0358677
TM4SF1 transmembrane 4 L six family member 1 -0.0352589
RPL34 ribosomal protein L34 -0.033659
RPS25 ribosomal protein S25 -0.033097
TNS3 tensin 3 -0.0329092
RPLP1 ribosomal protein, large, P1 -0.0328799
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0322226
RNF220 ring finger protein 220 -0.0316949
RPLP2 ribosomal protein, large, P2 -0.0301181
RPLP0 ribosomal protein, large, P0 -0.0301157
CTSD cathepsin D -0.0297023
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0295868
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0293492
TRIO trio Rho guanine nucleotide exchange factor -0.0287883
HMGA2 high mobility group AT-hook 2 -0.02866
TPM1 tropomyosin 1 (alpha) -0.0273828
IER3 immediate early response 3 -0.0273032
WSB1 WD repeat and SOCS box containing 1 -0.0269125
NUP98 nucleoporin 98kDa -0.0265111
RPL11 ribosomal protein L11 -0.0264045
RPS8 ribosomal protein S8 -0.0260567
EXT1 exostosin glycosyltransferase 1 -0.0259822
RPL12 ribosomal protein L12 -0.0256758
HMGA1 high mobility group AT-hook 1 -0.0246448
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0246233
RPS5 ribosomal protein S5 -0.0245538
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0244497
NABP1 nucleic acid binding protein 1 -0.0240878
RPS21 ribosomal protein S21 -0.0239
RPS13 ribosomal protein S13 -0.0238628
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0234137
EGFR epidermal growth factor receptor -0.0227484
RPL27A ribosomal protein L27a -0.0226795
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0225718
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0223718
DIAPH2 diaphanous-related formin 2 -0.0222118
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.022173
RPL9 ribosomal protein L9 -0.0220887
RPS19 ribosomal protein S19 -0.0216694
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0215583
INTS6 integrator complex subunit 6 -0.0213471
RAP1B RAP1B, member of RAS oncogene family -0.0213414
ZNF407 zinc finger protein 407 -0.0212416
RSU1 Ras suppressor protein 1 -0.0212119
PDLIM5 PDZ and LIM domain 5 -0.0209432
MSRB3 methionine sulfoxide reductase B3 -0.0209248
RPL31 ribosomal protein L31 -0.020785
H1-0 H1.0 linker histone -0.0204188
SBF2 SET binding factor 2 -0.0203028
NEK10 NIMA-related kinase 10 -0.0202917
LPP LIM domain containing preferred translocation partner in lipoma -0.0200807
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0199464
RPS23 ribosomal protein S23 -0.019841
RPL28 ribosomal protein L28 -0.0196906
COMMD10 COMM domain containing 10 -0.0195204
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0195107
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0194862
ATXN1 ataxin 1 -0.0192414
ZNF546 zinc finger protein 546 -0.0190187
RPL38 ribosomal protein L38 -0.0186536
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0183642
MCTP1 multiple C2 domains, transmembrane 1 -0.0183168
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0182697
TAS2R14 taste receptor, type 2, member 14 -0.0182111
THSD7A thrombospondin, type I, domain containing 7A -0.0179476
AGO3 argonaute RISC catalytic component 3 -0.0178619
RPL36A ribosomal protein L36a -0.0176448
HM13 histocompatibility (minor) 13 -0.0175832
LARP1B La ribonucleoprotein domain family, member 1B -0.0174707
RASAL2 RAS protein activator like 2 -0.0174088
TTC17 tetratricopeptide repeat domain 17 -0.0172676
NF1 neurofibromin 1 -0.0170192
RPS15 ribosomal protein S15 -0.0168875
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0167659
S100A6 S100 calcium binding protein A6 -0.0166473
CAVIN1 caveolae associated protein 1 -0.0165157
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.016499
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0164063
BABAM2 BRISC and BRCA1 A complex member 2 -0.0162761
PATJ PATJ crumbs cell polarity complex component -0.0160441
ATM ATM serine/threonine kinase -0.0160063