Gallic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 0.139285
EEF2 eukaryotic translation elongation factor 2 0.1273
ENO1 enolase 1, (alpha) 0.118058
ACTG1 actin gamma 1 0.109416
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0996799
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.098891
RPL3 ribosomal protein L3 0.0903297
ZEB1 zinc finger E-box binding homeobox 1 0.089321
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0838917
FLNB filamin B, beta 0.0820061
AHNAK AHNAK nucleoprotein 0.0809187
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0686326
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0655376
POTEF POTE ankyrin domain family, member F 0.0630778
EIF4B eukaryotic translation initiation factor 4B 0.059206
SET SET nuclear proto-oncogene 0.0577808
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.057189
EXT1 exostosin glycosyltransferase 1 0.0559752
ARHGAP22 Rho GTPase activating protein 22 0.0511531
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0500318
EIF4A1 eukaryotic translation initiation factor 4A1 0.0497536
RPL4 ribosomal protein L4 0.0491324
MYH9 myosin, heavy chain 9, non-muscle 0.0488007
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0487905
CAPRIN2 caprin family member 2 0.0485918
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0474731
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0469117
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0467092
CORO1C coronin, actin binding protein, 1C 0.0449203
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0448101
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0442023
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0439487
HSPA8 heat shock 70kDa protein 8 0.0438094
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426664
MACF1 microtubule-actin crosslinking factor 1 0.0417701
PBX3 pre-B-cell leukemia homeobox 3 0.0391552
NAV2 neuron navigator 2 0.0384565
DGKI diacylglycerol kinase, iota 0.0379916
APP amyloid beta (A4) precursor protein 0.0375908
PHC2 polyhomeotic homolog 2 (Drosophila) 0.037522
AKAP12 A kinase (PRKA) anchor protein 12 0.0367226
ENO2 enolase 2 (gamma, neuronal) 0.0366533
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0359497
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0354511
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0345549
LAMB3 laminin, beta 3 0.0345336
FAM120A family with sequence similarity 120A 0.0339138
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0333735
NUDC nudC nuclear distribution protein 0.0332651
FRMD6 FERM domain containing 6 0.0330368
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0326824
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.032153
TPM3 tropomyosin 3 0.0320939
PDIA6 protein disulfide isomerase family A, member 6 0.0320196
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0317337
YBX1 Y box binding protein 1 0.0315713
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0307191
RPS3 ribosomal protein S3 0.0305602
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0299943
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0297862
TMEM156 transmembrane protein 156 0.0293813
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0290211
SFPQ splicing factor proline/glutamine-rich 0.028846
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0287399
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286558
PKM pyruvate kinase, muscle 0.0286122
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0286004
SRRM2 serine/arginine repetitive matrix 2 0.028313
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0278091
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272802
DSCAM Down syndrome cell adhesion molecule 0.0270849
CCNY cyclin Y 0.0270393
TPM4 tropomyosin 4 0.0264009
NEMP2 nuclear envelope integral membrane protein 2 0.0263181
CALR calreticulin 0.0259596
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0259458
USP9X ubiquitin specific peptidase 9, X-linked 0.0257499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0255534
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0248331
TAC4 tachykinin 4 (hemokinin) 0.0245492
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0241487
APLP2 amyloid beta (A4) precursor-like protein 2 0.0240468
PCBP2 poly(rC) binding protein 2 0.0238274
DST dystonin 0.0235073
KDM5C lysine (K)-specific demethylase 5C 0.0234501
RPL14 ribosomal protein L14 0.0234366
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0233566
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0232072
KDM4C lysine (K)-specific demethylase 4C 0.0230897
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0230351
SAMD4A sterile alpha motif domain containing 4A 0.0230008
ANK2 ankyrin 2, neuronal 0.0228935
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0228409
GIGYF2 GRB10 interacting GYF protein 2 0.0227523
SMC1A structural maintenance of chromosomes 1A 0.0226485
HDAC9 histone deacetylase 9 0.0225268
PRELID2 PRELI domain containing 2 0.022522
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0225215
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0220462
ADTRP androgen-dependent TFPI-regulating protein 0.0216408

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.154021
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.139111
STC1 stanniocalcin 1 -0.0891389
RPL8 ribosomal protein L8 -0.0646411
RPS6 ribosomal protein S6 -0.0634505
NABP1 nucleic acid binding protein 1 -0.0629152
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.059146
HMGA1 high mobility group AT-hook 1 -0.0577315
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0564397
DIAPH3 diaphanous-related formin 3 -0.0562641
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0557517
SLC38A2 solute carrier family 38, member 2 -0.0543696
RBM25 RNA binding motif protein 25 -0.0526412
RPL35A ribosomal protein L35a -0.0485138
EGR1 early growth response 1 -0.0471286
TTR transthyretin -0.0452279
MT2A metallothionein 2A -0.0444385
RAB7A RAB7A, member RAS oncogene family -0.0436003
PCNX4 pecanex 4 -0.0421986
RPL34 ribosomal protein L34 -0.0421613
RPL12 ribosomal protein L12 -0.0418717
LPP LIM domain containing preferred translocation partner in lipoma -0.0408923
TRIO trio Rho guanine nucleotide exchange factor -0.0406243
RAD21 RAD21 homolog (S. pombe) -0.0404827
SP100 SP100 nuclear antigen -0.039366
NAV3 neuron navigator 3 -0.0393526
RPL32 ribosomal protein L32 -0.0390923
MTAP methylthioadenosine phosphorylase -0.0384481
RPS24 ribosomal protein S24 -0.0382282
IFI16 interferon, gamma-inducible protein 16 -0.0381398
LARP4B La ribonucleoprotein domain family, member 4B -0.0374698
TMSB10 thymosin beta 10 -0.0370484
NF1 neurofibromin 1 -0.0370173
NAP1L1 nucleosome assembly protein 1-like 1 -0.0369966
GNAS GNAS complex locus -0.0369149
WSB1 WD repeat and SOCS box containing 1 -0.0361459
SNX14 sorting nexin 14 -0.0334564
INTS6 integrator complex subunit 6 -0.0334466
LOC112694756 uncharaterized LOC112694756 -0.0332166
HLA-C major histocompatibility complex, class I, C -0.0330092
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0323687
RPS21 ribosomal protein S21 -0.0321613
PFN1 profilin 1 -0.0320133
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0317784
CALD1 caldesmon 1 -0.0317544
RBM39 RNA binding motif protein 39 -0.0317443
PNISR PNN-interacting serine/arginine-rich protein -0.0313837
PLSCR1 phospholipid scramblase 1 -0.0307118
SBF2 SET binding factor 2 -0.0306234
TPT1 tumor protein, translationally-controlled 1 -0.0306
TASOR2 transcription activation suppressor family member 2 -0.0303523
ZFAND3 zinc finger, AN1-type domain 3 -0.0297869
FUBP3 far upstream element (FUSE) binding protein 3 -0.0297841
RPS15 ribosomal protein S15 -0.0290937
PRRC2B proline-rich coiled-coil 2B -0.028899
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0278451
BIRC6 baculoviral IAP repeat containing 6 -0.0274949
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0274085
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0264924
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0263803
MKI67 marker of proliferation Ki-67 -0.0263339
ZNF438 zinc finger protein 438 -0.026236
PARD3 par-3 family cell polarity regulator -0.0260837
MTPN myotrophin -0.026016
RPL28 ribosomal protein L28 -0.0259366
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0259167
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0259058
IARS1 isoleucyl-tRNA synthetase 1 -0.0255145
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0254872
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0252561
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0252112
C2CD2 C2 calcium-dependent domain containing 2 -0.02485
RBBP6 retinoblastoma binding protein 6 -0.0246487
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0245511
MCTP1 multiple C2 domains, transmembrane 1 -0.0243242
FUS FUS RNA binding protein -0.0238762
RPL36A ribosomal protein L36a -0.0238422
RPS19 ribosomal protein S19 -0.0237665
NRF1 nuclear respiratory factor 1 -0.0236959
LCORL ligand dependent nuclear receptor corepressor-like -0.023634
RPL35 ribosomal protein L35 -0.0229506
ARF1 ADP-ribosylation factor 1 -0.0227291
TBCA tubulin folding cofactor A -0.0225759
RPLP1 ribosomal protein, large, P1 -0.0225728
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.022519
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0224983
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0223218
CCND2 cyclin D2 -0.022118
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0221076
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0218257
TEX10 testis expressed 10 -0.0217799
S100A2 S100 calcium binding protein A2 -0.0217259
NOP58 NOP58 ribonucleoprotein -0.0217027
RHEB Ras homolog enriched in brain -0.0216612
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0215853
HMGB1 high mobility group box 1 -0.0215547
STAU1 staufen double-stranded RNA binding protein 1 -0.0215482
SMC4 structural maintenance of chromosomes 4 -0.0213587
POU2F1 POU class 2 homeobox 1 -0.0213582
RPL27A ribosomal protein L27a -0.0213503