Gallic acid_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.140323
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.132161
ENO1 enolase 1, (alpha) 0.0963568
VEGFA vascular endothelial growth factor A 0.0920967
AKAP12 A kinase (PRKA) anchor protein 12 0.0798365
SMAD3 SMAD family member 3 0.0685105
POTEF POTE ankyrin domain family, member F 0.0678757
ANGPTL4 angiopoietin-like 4 0.0668477
IGFBP3 insulin-like growth factor binding protein 3 0.0629523
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0618163
JARID2 jumonji, AT rich interactive domain 2 0.0614917
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0587342
MMP2 matrix metallopeptidase 2 0.0574688
TIMP1 TIMP metallopeptidase inhibitor 1 0.0522483
WWTR1 WW domain containing transcription regulator 1 0.0520266
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.050694
COL5A1 collagen, type V, alpha 1 0.0506633
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0498801
MCL1 myeloid cell leukemia 1 0.0495452
IFI6 interferon, alpha-inducible protein 6 0.0490751
NRIP1 nuclear receptor interacting protein 1 0.0484989
MYH9 myosin, heavy chain 9, non-muscle 0.047349
IFI44L interferon-induced protein 44-like 0.0440909
FAT1 FAT atypical cadherin 1 0.0436287
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0430279
FLNB filamin B, beta 0.0420601
LOC102724023 ES1 protein homolog, mitochondrial 0.0399787
HDAC9 histone deacetylase 9 0.0392634
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0388337
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0371998
TGM2 transglutaminase 2 0.0371334
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0361271
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0346337
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0343141
NPAS2 neuronal PAS domain protein 2 0.0342592
ENO2 enolase 2 (gamma, neuronal) 0.0331874
STC1 stanniocalcin 1 0.0331572
EEF2 eukaryotic translation elongation factor 2 0.0327481
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321344
SVIL supervillin 0.0319393
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0315813
HLA-B major histocompatibility complex, class I, B 0.031561
HMGA2 high mobility group AT-hook 2 0.0308394
FAM20C family with sequence similarity 20, member C 0.0305201
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301325
HSPA8 heat shock 70kDa protein 8 0.0301211
LDHA lactate dehydrogenase A 0.0294157
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0291594
RPS17 ribosomal protein S17 0.0288077
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0281714
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.02795
RPS12 ribosomal protein S12 0.0278275
RPL3 ribosomal protein L3 0.027745
HIPK2 homeodomain interacting protein kinase 2 0.0274451
TPM3 tropomyosin 3 0.0264088
AHNAK AHNAK nucleoprotein 0.0263921
C1D C1D nuclear receptor corepressor 0.02594
AFDN afadin, adherens junction formation factor 0.0254275
RPS3 ribosomal protein S3 0.0254249
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0254002
FTH1 ferritin, heavy polypeptide 1 0.0249738
DOCK5 dedicator of cytokinesis 5 0.024724
ZBTB38 zinc finger and BTB domain containing 38 0.024317
SRRM2 serine/arginine repetitive matrix 2 0.0240883
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.023983
PLEC plectin 0.0238131
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0235227
ERRFI1 ERBB receptor feedback inhibitor 1 0.0234769
PDIA6 protein disulfide isomerase family A, member 6 0.0233009
NAV2 neuron navigator 2 0.0231785
RPL23 ribosomal protein L23 0.0231189
GADD45B growth arrest and DNA-damage-inducible, beta 0.0230029
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0229123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022875
PCBP2 poly(rC) binding protein 2 0.022818
SEPTIN9 septin 9 0.0228113
MX1 MX dynamin-like GTPase 1 0.0225582
RB1CC1 RB1-inducible coiled-coil 1 0.0225038
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0224333
ANXA2 annexin A2 0.0223633
SFPQ splicing factor proline/glutamine-rich 0.022279
MSN moesin 0.022233
PLAT plasminogen activator, tissue 0.0221994
AXL AXL receptor tyrosine kinase 0.0220849
NOTCH2 notch 2 0.0220089
NFE2L1 nuclear factor, erythroid 2-like 1 0.0216796
HLA-A major histocompatibility complex, class I, A 0.0214491
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0214006
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0213275
ECE1 endothelin converting enzyme 1 0.0211687
COL4A1 collagen, type IV, alpha 1 0.0210575
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0210206
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0210056
APP amyloid beta (A4) precursor protein 0.0209987
PKM pyruvate kinase, muscle 0.0206512
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0202909
CALR calreticulin 0.0201117
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0200865
RNF144A ring finger protein 144A 0.0200781
BRD2 bromodomain containing 2 0.0199722

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.254608
COL1A1 collagen, type I, alpha 1 -0.18686
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.156156
CDH13 cadherin 13 -0.114673
CXCL8 chemokine (C-X-C motif) ligand 8 -0.105362
ZEB1 zinc finger E-box binding homeobox 1 -0.0910602
COL6A2 collagen, type VI, alpha 2 -0.0876892
NDRG1 N-myc downstream regulated 1 -0.0758528
FNDC3B fibronectin type III domain containing 3B -0.0735555
PDE4D phosphodiesterase 4D, cAMP-specific -0.0675541
FRMD4A FERM domain containing 4A -0.0619495
TFPI2 tissue factor pathway inhibitor 2 -0.0608491
VIM vimentin -0.0603064
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0596261
IER3 immediate early response 3 -0.059412
COL6A1 collagen, type VI, alpha 1 -0.0587943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0552224
EXT1 exostosin glycosyltransferase 1 -0.0544714
RRBP1 ribosome binding protein 1 -0.0536598
HDLBP high density lipoprotein binding protein -0.0524817
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0521789
TPM4 tropomyosin 4 -0.0521664
SLIT2 slit homolog 2 (Drosophila) -0.0518825
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0517621
TNNC1 troponin C type 1 (slow) -0.0509776
H1-0 H1.0 linker histone -0.0497218
RAB7A RAB7A, member RAS oncogene family -0.0488974
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0486078
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0483903
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.048259
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0472076
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0471421
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0454751
VCAN versican -0.0454745
GNAS GNAS complex locus -0.0442114
MMP12 matrix metallopeptidase 12 -0.0432394
CALU calumenin -0.0426616
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0421943
GLIS3 GLIS family zinc finger 3 -0.0409289
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0402422
PGK1 phosphoglycerate kinase 1 -0.0397266
RAB1A RAB1A, member RAS oncogene family -0.0389085
XAF1 XIAP associated factor 1 -0.0388169
TMSB10 thymosin beta 10 -0.0383504
ITGA1 integrin, alpha 1 -0.0383143
PSD3 pleckstrin and Sec7 domain containing 3 -0.0379868
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0379074
SEC31A SEC31 homolog A (S. cerevisiae) -0.0376395
GARS1 glycyl-tRNA synthetase 1 -0.0371337
WSB1 WD repeat and SOCS box containing 1 -0.0370615
NAMPT nicotinamide phosphoribosyltransferase -0.0367825
TPM1 tropomyosin 1 (alpha) -0.0366433
IFI16 interferon, gamma-inducible protein 16 -0.0364152
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0364072
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0363747
TMEM263 transmembrane protein 263 -0.0363043
PTMA prothymosin, alpha -0.036093
TNS3 tensin 3 -0.0360753
NREP neuronal regeneration related protein -0.0359398
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0346912
PDIA3 protein disulfide isomerase family A, member 3 -0.0343135
COL1A2 collagen, type I, alpha 2 -0.033895
VCL vinculin -0.0327674
KDM3A lysine (K)-specific demethylase 3A -0.0327129
SEC24D SEC24 family member D -0.0324663
NAV1 neuron navigator 1 -0.0324305
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0324225
GOLGA4 golgin A4 -0.032418
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0321988
TRIO trio Rho guanine nucleotide exchange factor -0.0321758
INHBA inhibin, beta A -0.0321697
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0318596
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0318147
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0317192
SETD5 SET domain containing 5 -0.031464
ZFAND3 zinc finger, AN1-type domain 3 -0.0314474
SP100 SP100 nuclear antigen -0.0313619
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0311541
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0310828
RAB2A RAB2A, member RAS oncogene family -0.0309539
GRB10 growth factor receptor-bound protein 10 -0.0309342
SLC38A2 solute carrier family 38, member 2 -0.0305838
MAML2 mastermind-like 2 (Drosophila) -0.0305368
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0304141
TFG TRK-fused gene -0.0303149
LPP LIM domain containing preferred translocation partner in lipoma -0.0302492
FBXO11 F-box protein 11 -0.0299224
MCTP2 multiple C2 domains, transmembrane 2 -0.0298132
SMC4 structural maintenance of chromosomes 4 -0.0297604
BIRC6 baculoviral IAP repeat containing 6 -0.0296733
BICC1 BicC family RNA binding protein 1 -0.0289174
RBM39 RNA binding motif protein 39 -0.0289022
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0287707
FMNL2 formin-like 2 -0.0287374
MORF4L2 mortality factor 4 like 2 -0.0286566
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0283818
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0282938
SNX14 sorting nexin 14 -0.0281622
ZMYND8 zinc finger, MYND-type containing 8 -0.028106
QKI QKI, KH domain containing, RNA binding -0.0279955