Gallic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG3 neuregulin 3 0.178448
FMN1 formin 1 0.15611
FN1 fibronectin 1 0.123375
DST dystonin 0.111478
FNDC3B fibronectin type III domain containing 3B 0.102352
PRELID2 PRELI domain containing 2 0.0810818
NLGN1 neuroligin 1 0.0774197
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0760343
IGF1R insulin-like growth factor 1 receptor 0.0731201
FMNL2 formin-like 2 0.072269
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0719628
FHIT fragile histidine triad 0.0715655
AHNAK AHNAK nucleoprotein 0.0707071
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0705884
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0700834
RAD51B RAD51 paralog B 0.0641948
FRMD4A FERM domain containing 4A 0.0632308
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0611288
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0581419
FLNA filamin A, alpha 0.0567144
ENO1 enolase 1, (alpha) 0.0558269
RUNX1 runt-related transcription factor 1 0.0556557
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0537844
RNF213 ring finger protein 213 0.0533131
ASPH aspartate beta-hydroxylase 0.0520082
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0498802
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0494775
WWTR1 WW domain containing transcription regulator 1 0.0481975
PLEC plectin 0.0480341
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0461949
LRMDA leucine rich melanocyte differentiation associated 0.0458983
ZBTB20 zinc finger and BTB domain containing 20 0.0450731
MYH9 myosin, heavy chain 9, non-muscle 0.0446115
LINGO2 leucine rich repeat and Ig domain containing 2 0.0442977
MACROD2 MACRO domain containing 2 0.0442197
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0441458
HDAC9 histone deacetylase 9 0.0433241
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0429703
PTK2 protein tyrosine kinase 2 0.0426245
LPP LIM domain containing preferred translocation partner in lipoma 0.0424678
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0415658
OSBPL10 oxysterol binding protein-like 10 0.0400613
ATXN1 ataxin 1 0.0399349
ZBTB38 zinc finger and BTB domain containing 38 0.0398721
AKAP12 A kinase (PRKA) anchor protein 12 0.0395301
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0390468
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.038698
INPP5F inositol polyphosphate-5-phosphatase F 0.0384543
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0381693
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0378864
FRMD5 FERM domain containing 5 0.0369516
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0361285
EXOC4 exocyst complex component 4 0.0352077
AFDN afadin, adherens junction formation factor 0.0349559
OGA O-GlcNAcase 0.034718
SFTPA2 surfactant protein A2 0.0345933
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0334078
PTPRG protein tyrosine phosphatase, receptor type, G 0.0333891
MAML3 mastermind-like 3 (Drosophila) 0.0333563
MACF1 microtubule-actin crosslinking factor 1 0.0331424
PGK1 phosphoglycerate kinase 1 0.0328874
AKAP13 A kinase (PRKA) anchor protein 13 0.0328755
SVIL supervillin 0.0327374
FLNB filamin B, beta 0.0326968
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326346
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0324976
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.032308
CFAP20DC CFAP20 domain containing 0.0323006
PDE4D phosphodiesterase 4D, cAMP-specific 0.0317757
HDAC4 histone deacetylase 4 0.031702
RNF144A ring finger protein 144A 0.0313528
SUMF1 sulfatase modifying factor 1 0.0311173
FBXL17 F-box and leucine-rich repeat protein 17 0.0307315
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0305571
SLC39A11 solute carrier family 39, member 11 0.0305567
NFE2L1 nuclear factor, erythroid 2-like 1 0.0304817
TRIO trio Rho guanine nucleotide exchange factor 0.0300401
EHBP1 EH domain binding protein 1 0.0300031
NAV1 neuron navigator 1 0.0299694
MCL1 myeloid cell leukemia 1 0.0296023
CDK6 cyclin-dependent kinase 6 0.0295817
NAV2 neuron navigator 2 0.0294954
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0293825
NOTCH2 notch 2 0.0292143
KDM4C lysine (K)-specific demethylase 4C 0.0291407
ETV6 ets variant 6 0.0288838
SOX6 SRY (sex determining region Y)-box 6 0.0286588
IGFBP3 insulin-like growth factor binding protein 3 0.0284401
MSN moesin 0.028403
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0280258
BACE2 beta-site APP-cleaving enzyme 2 0.0279978
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0279317
MAP4 microtubule-associated protein 4 0.027919
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0276687
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0274901
MELTF melanotransferrin 0.0273722
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0273259
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0271762
CRYBG3 beta-gamma crystallin domain containing 3 0.0270691
TRIP12 thyroid hormone receptor interactor 12 0.026997

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.170207
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128192
FTL ferritin, light polypeptide -0.0935511
MT2A metallothionein 2A -0.090463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0767487
RPS6 ribosomal protein S6 -0.0758568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0723516
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0650376
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0623996
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0622146
RPL35A ribosomal protein L35a -0.0606094
GOLGA4 golgin A4 -0.0603255
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0525691
TMSB10 thymosin beta 10 -0.0488736
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0480194
VDAC1 voltage-dependent anion channel 1 -0.0473817
EIF1 eukaryotic translation initiation factor 1 -0.0469023
RPLP1 ribosomal protein, large, P1 -0.043559
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0413458
TPT1 tumor protein, translationally-controlled 1 -0.0390437
RPS13 ribosomal protein S13 -0.0370663
HMGA1 high mobility group AT-hook 1 -0.0354308
RPL34 ribosomal protein L34 -0.0352144
RPL23 ribosomal protein L23 -0.0348669
RPL11 ribosomal protein L11 -0.0337615
RPS8 ribosomal protein S8 -0.0336488
LSAMP limbic system-associated membrane protein -0.0317103
GARS1 glycyl-tRNA synthetase 1 -0.0313938
NDRG1 N-myc downstream regulated 1 -0.0308176
RPS23 ribosomal protein S23 -0.0305212
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0304799
RPL9 ribosomal protein L9 -0.0295364
RPL12 ribosomal protein L12 -0.0288521
RPL32 ribosomal protein L32 -0.0285551
RPS24 ribosomal protein S24 -0.0278809
RTN4 reticulon 4 -0.0278596
CCND1 cyclin D1 -0.027691
RPL31 ribosomal protein L31 -0.0273383
RPS12 ribosomal protein S12 -0.0267046
RPS21 ribosomal protein S21 -0.0263471
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263453
RACK1 receptor for activated C kinase 1 -0.0261471
PDIA3 protein disulfide isomerase family A, member 3 -0.025935
RPLP2 ribosomal protein, large, P2 -0.0256617
SREBF2 sterol regulatory element binding transcription factor 2 -0.0249517
RPS3 ribosomal protein S3 -0.024913
RPL19 ribosomal protein L19 -0.02455
PTMA prothymosin, alpha -0.024537
RPS16 ribosomal protein S16 -0.0242863
RPL5 ribosomal protein L5 -0.0238976
RPS5 ribosomal protein S5 -0.0238664
RPL38 ribosomal protein L38 -0.0235951
TTC3 tetratricopeptide repeat domain 3 -0.0233637
S100A9 S100 calcium binding protein A9 -0.0230634
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.022962
NAP1L1 nucleosome assembly protein 1-like 1 -0.022813
RPL37A ribosomal protein L37a -0.0225081
RBM25 RNA binding motif protein 25 -0.0223282
RPL36 ribosomal protein L36 -0.0222803
RPLP0 ribosomal protein, large, P0 -0.0220945
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0216447
TSC22D2 TSC22 domain family, member 2 -0.021637
RPL26 ribosomal protein L26 -0.0214635
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0212894
RPS14 ribosomal protein S14 -0.0209614
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0205194
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0203461
NAMPT nicotinamide phosphoribosyltransferase -0.0203256
RPS27 ribosomal protein S27 -0.0202361
RPL37 ribosomal protein L37 -0.0200508
RAB7A RAB7A, member RAS oncogene family -0.0199422
TFPI2 tissue factor pathway inhibitor 2 -0.0199218
RPL36A ribosomal protein L36a -0.0198878
RPS10 ribosomal protein S10 -0.0198446
RPS29 ribosomal protein S29 -0.0197594
IER3 immediate early response 3 -0.0197081
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.019583
RPS19 ribosomal protein S19 -0.0194052
RPS15 ribosomal protein S15 -0.0191426
WDR45B WD repeat domain 45B -0.0191032
RPS27A ribosomal protein S27a -0.0184781
KPNB1 karyopherin (importin) beta 1 -0.0181321
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0180113
ACBD3 acyl-CoA binding domain containing 3 -0.01789
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0178686
LMAN1 lectin, mannose-binding, 1 -0.0177787
RPL28 ribosomal protein L28 -0.0176908
RPL30 ribosomal protein L30 -0.0175574
RPL8 ribosomal protein L8 -0.0173158
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0168675
LDHB lactate dehydrogenase B -0.0164926
SNU13 small nuclear ribonucleoprotein 13 -0.0164369
CCNI cyclin I -0.0164288
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0163754
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0161785
H3-3B H3.3 histone B -0.0161394
TMEM263 transmembrane protein 263 -0.0161386
EIF5B eukaryotic translation initiation factor 5B -0.0160888
NOP58 NOP58 ribonucleoprotein -0.0159799
PFN1 profilin 1 -0.0156141