Gallic acid_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.211069
AKAP12 A kinase (PRKA) anchor protein 12 0.20693
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.135171
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.11972
MYH9 myosin, heavy chain 9, non-muscle 0.10838
TIMP1 TIMP metallopeptidase inhibitor 1 0.106195
MYO10 myosin X 0.0967686
FN1 fibronectin 1 0.0927031
PALM2AKAP2 PALM2 and AKAP2 fusion 0.065605
ACTG1 actin gamma 1 0.061182
SPRED1 sprouty-related, EVH1 domain containing 1 0.0605458
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0561024
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0541622
CD44 CD44 molecule (Indian blood group) 0.0531009
SMAD3 SMAD family member 3 0.0515705
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0442204
COL1A1 collagen, type I, alpha 1 0.0426675
AHNAK AHNAK nucleoprotein 0.0422371
MSN moesin 0.0412057
POTEF POTE ankyrin domain family, member F 0.0358886
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0352814
ARHGAP21 Rho GTPase activating protein 21 0.035004
EEF2 eukaryotic translation elongation factor 2 0.0345837
ENO1 enolase 1, (alpha) 0.0341929
WWTR1 WW domain containing transcription regulator 1 0.033635
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0330327
SPRED2 sprouty-related, EVH1 domain containing 2 0.0320025
LOXL2 lysyl oxidase-like 2 0.0316138
RUNX1 runt-related transcription factor 1 0.0311903
MACF1 microtubule-actin crosslinking factor 1 0.0310564
RPL3 ribosomal protein L3 0.0306185
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.03043
APP amyloid beta (A4) precursor protein 0.029787
TLN1 talin 1 0.029678
EXT1 exostosin glycosyltransferase 1 0.0295582
PKM pyruvate kinase, muscle 0.0280816
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0280137
RPL4 ribosomal protein L4 0.0275079
PRRC2C proline-rich coiled-coil 2C 0.0274356
PCBP2 poly(rC) binding protein 2 0.0272058
HSPA8 heat shock 70kDa protein 8 0.0270633
NAMPT nicotinamide phosphoribosyltransferase 0.0269655
ATP13A3 ATPase type 13A3 0.0268041
EIF4B eukaryotic translation initiation factor 4B 0.0264013
HAS2 hyaluronan synthase 2 0.0260489
NFE2L1 nuclear factor, erythroid 2-like 1 0.0256982
COL1A2 collagen, type I, alpha 2 0.0254212
COL5A3 collagen, type V, alpha 3 0.0246984
NIBAN2 niban apoptosis regulator 2 0.0246798
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0246665
FOXP1 forkhead box P1 0.0243365
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0239396
MCL1 myeloid cell leukemia 1 0.0231571
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0226914
ADAMTSL1 ADAMTS-like 1 0.0225438
SEPTIN9 septin 9 0.022213
CDK17 cyclin-dependent kinase 17 0.0216135
MED13L mediator complex subunit 13-like 0.0215767
SFPQ splicing factor proline/glutamine-rich 0.0215352
SAMD4A sterile alpha motif domain containing 4A 0.0214044
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0209908
ANKRD28 ankyrin repeat domain 28 0.0203616
FRMD6 FERM domain containing 6 0.0202663
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0200355
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0196371
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0195234
FAT1 FAT atypical cadherin 1 0.0193562
JAG1 jagged 1 0.0192365
VEGFC vascular endothelial growth factor C 0.0192045
SH3RF1 SH3 domain containing ring finger 1 0.0186044
ARHGAP31 Rho GTPase activating protein 31 0.0185104
SATB2 SATB homeobox 2 0.0184992
NT5E 5'-nucleotidase, ecto (CD73) 0.0183934
MYO1B myosin IB 0.0183825
SEPTIN11 septin 11 0.0183391
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0183278
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.018273
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0182668
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0181829
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0181745
NOTCH2 notch 2 0.0178628
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177432
ARHGAP32 Rho GTPase activating protein 32 0.0176304
TPM3 tropomyosin 3 0.0174758
KIAA1549L KIAA1549-like 0.0174152
ANXA5 annexin A5 0.0171844
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0170713
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0169746
DSPP dentin sialophosphoprotein 0.0169477
EIF4A1 eukaryotic translation initiation factor 4A1 0.0167083
MT2A metallothionein 2A 0.0165908
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0163266
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0163093
PRICKLE2 prickle homolog 2 (Drosophila) 0.0162744
SH3KBP1 SH3-domain kinase binding protein 1 0.0162423
MPRIP myosin phosphatase Rho interacting protein 0.0158149
TOP2B topoisomerase (DNA) II beta 180kDa 0.0157661
ASPH aspartate beta-hydroxylase 0.0156574
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0155718
IGF2R insulin-like growth factor 2 receptor 0.015552

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.224446
PRKG1 protein kinase, cGMP-dependent, type I -0.156489
HMGA2 high mobility group AT-hook 2 -0.141327
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138613
STC1 stanniocalcin 1 -0.133742
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.130778
CXCL8 chemokine (C-X-C motif) ligand 8 -0.125768
INHBA inhibin, beta A -0.119809
VIM vimentin -0.119643
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.111277
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.110936
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.1065
NDRG1 N-myc downstream regulated 1 -0.0953088
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0934329
HLA-B major histocompatibility complex, class I, B -0.0885706
OXR1 oxidation resistance 1 -0.0870128
GREM1 gremlin 1, DAN family BMP antagonist -0.0857108
CDH13 cadherin 13 -0.0689301
MMP1 matrix metallopeptidase 1 -0.0686574
TPT1 tumor protein, translationally-controlled 1 -0.0672948
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0650566
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0631316
AFF3 AF4/FMR2 family, member 3 -0.0592511
NCKAP5 NCK-associated protein 5 -0.0570807
COL6A2 collagen, type VI, alpha 2 -0.0564695
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0555558
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.054146
JARID2 jumonji, AT rich interactive domain 2 -0.0522781
TM4SF1 transmembrane 4 L six family member 1 -0.0498363
TMSB10 thymosin beta 10 -0.0494341
COL8A1 collagen, type VIII, alpha 1 -0.0477071
LMAN1 lectin, mannose-binding, 1 -0.0470275
INTS6 integrator complex subunit 6 -0.0452785
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.044977
FRMPD4 FERM and PDZ domain containing 4 -0.0440856
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0439633
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0432489
ABI3BP ABI family, member 3 (NESH) binding protein -0.0428365
TFPI2 tissue factor pathway inhibitor 2 -0.0428002
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0401677
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0385821
TGFBI transforming growth factor, beta-induced, 68kDa -0.0385132
MMP12 matrix metallopeptidase 12 -0.0383002
SEC24D SEC24 family member D -0.0374713
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0367186
RPL34 ribosomal protein L34 -0.0365416
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0357515
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0354462
CEMIP cell migration inducing protein, hyaluronan binding -0.0352926
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0349123
SAMD3 sterile alpha motif domain containing 3 -0.0345222
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0344813
ADM adrenomedullin -0.0341755
NBEAL1 neurobeachin-like 1 -0.0329934
ITGA1 integrin, alpha 1 -0.0319159
DNER delta/notch-like EGF repeat containing -0.0304152
MEIS1 Meis homeobox 1 -0.0302176
MAML3 mastermind-like 3 (Drosophila) -0.0300152
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0295722
WSB1 WD repeat and SOCS box containing 1 -0.0294626
PRRX1 paired related homeobox 1 -0.0292621
EFCAB13 EF-hand calcium binding domain 13 -0.0287434
VCL vinculin -0.0284563
COL6A1 collagen, type VI, alpha 1 -0.0283209
IER3 immediate early response 3 -0.0281701
HLA-A major histocompatibility complex, class I, A -0.0281125
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0279849
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0278152
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0271777
SLC38A2 solute carrier family 38, member 2 -0.0269469
ANKRD12 ankyrin repeat domain 12 -0.0268059
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.02651
TTC3 tetratricopeptide repeat domain 3 -0.026196
TMEM263 transmembrane protein 263 -0.0260104
SEC31A SEC31 homolog A (S. cerevisiae) -0.0257818
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0257013
EIF1 eukaryotic translation initiation factor 1 -0.0255963
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0255017
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0252789
DGKI diacylglycerol kinase, iota -0.0251384
TTC23L tetratricopeptide repeat domain 23-like -0.0245792
TPM4 tropomyosin 4 -0.0244395
NGLY1 N-glycanase 1 -0.0242757
FNIP1 folliculin interacting protein 1 -0.0242106
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0241343
SPDYA speedy/RINGO cell cycle regulator family member A -0.024116
PDIA3 protein disulfide isomerase family A, member 3 -0.0240995
FGFR1 fibroblast growth factor receptor 1 -0.0240803
TLE4 transducin-like enhancer of split 4 -0.0240388
NPTX1 neuronal pentraxin I -0.0239938
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.023824
GNAS GNAS complex locus -0.0235777
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0234747
DLC1 DLC1 Rho GTPase activating protein -0.0233242
SLIT2 slit homolog 2 (Drosophila) -0.0232052
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0231991
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0230452
RAB1A RAB1A, member RAS oncogene family -0.0230396
PRELID2 PRELI domain containing 2 -0.0229857
SNX14 sorting nexin 14 -0.0229771