| Dataset | CORUM Protein Complexes |
| Category | structural or functional annotations |
| Type | protein complex |
| Description | A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765) |
| External Link | http://mips.helmholtz-muenchen.de/genre/proj/corum/complexdetails.html?id=468 |
| Similar Terms | |
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4 proteins in the Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.
