Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) Gene Set

Dataset CORUM Protein Complexes
Category structural or functional annotations
Type protein complex
Description A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765)
External Link
Similar Terms
Downloads & Tools


4 proteins in the Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) protein complex from the CORUM Protein Complexes dataset.

Symbol Name
APH1B APH1B gamma secretase subunit
NCSTN nicastrin
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit