Ganglioneuroblastoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, and nodular.|A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea (MeSH).|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular. (Experimental Factor Ontology, EFO_0000502)
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Genes

144 genes co-occuring with the disease Ganglioneuroblastoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 3.284
PHOX2B paired-like homeobox 2b 2.752
VIP vasoactive intestinal peptide 2.604
ENO2 enolase 2 (gamma, neuronal) 2.482
SYP synaptophysin 2.443
ALK anaplastic lymphoma receptor tyrosine kinase 2.083
CHGA chromogranin A 2.068
NF1 neurofibromin 1 1.934
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.878
PHOX2A paired-like homeobox 2a 1.872
FOXR2 forkhead box R2 1.856
CD99 CD99 molecule 1.838
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.835
CD99L2 CD99 molecule-like 2 1.832
TH tyrosine hydroxylase 1.75
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.737
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.725
NBL1 neuroblastoma 1, DAN family BMP antagonist 1.703
SOX10 SRY (sex determining region Y)-box 10 1.678
SST somatostatin 1.661
NCAM1 neural cell adhesion molecule 1 1.656
TP53 tumor protein p53 1.616
POMC proopiomelanocortin 1.602
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.6
NGFR nerve growth factor receptor 1.581
NPY neuropeptide Y 1.571
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.561
EWSR1 EWS RNA-binding protein 1 1.56
RET ret proto-oncogene 1.553
LIN28B lin-28 homolog B (C. elegans) 1.545
GFAP glial fibrillary acidic protein 1.542
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.537
WASF3 WAS protein family, member 3 1.52
TERT telomerase reverse transcriptase 1.515
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.498
HRAS Harvey rat sarcoma viral oncogene homolog 1.455
LIN28A lin-28 homolog A (C. elegans) 1.451
MN1 meningioma (disrupted in balanced translocation) 1 1.442
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.441
PNMT phenylethanolamine N-methyltransferase 1.425
NGF nerve growth factor (beta polypeptide) 1.425
SDHAF2 succinate dehydrogenase complex assembly factor 2 1.418
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.386
ASCL1 achaete-scute family bHLH transcription factor 1 1.383
LMO1 LIM domain only 1 (rhombotin 1) 1.38
SHH sonic hedgehog 1.366
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.36
TMEM127 transmembrane protein 127 1.354
GALP galanin-like peptide 1.353
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.342
OLIG2 oligodendrocyte lineage transcription factor 2 1.341
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.34
MYOG myogenin (myogenic factor 4) 1.33
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.33
TGFBR3L transforming growth factor, beta receptor III-like 1.301
CCND1 cyclin D1 1.274
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.267
BARD1 BRCA1 associated RING domain 1 1.264
TUBB3 tubulin, beta 3 class III 1.244
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.239
CD177 CD177 molecule 1.228
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 1.227
FOXR1 forkhead box R1 1.223
CCDC32 coiled-coil domain containing 32 1.221
CD34 CD34 molecule 1.216
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.21
MAX MYC associated factor X 1.201
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.189
GATA3 GATA binding protein 3 1.187
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.184
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.182
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.166
NES nestin 1.161
CASZ1 castor zinc finger 1 1.161
CHGB chromogranin B 1.157
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.156
NDN necdin, melanoma antigen (MAGE) family member 1.154
RBMXL3 RNA binding motif protein, X-linked-like 3 1.152
CDKN2A cyclin-dependent kinase inhibitor 2A 1.15
NTF3 neurotrophin 3 1.149
RAI1 retinoic acid induced 1 1.149
TTYH1 tweety family member 1 1.146
NUTM2D NUT family member 2D 1.146
PTPRD protein tyrosine phosphatase, receptor type, D 1.14
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 1.138
NTS neurotensin 1.134
SAMD5 sterile alpha motif domain containing 5 1.13
HAND2 heart and neural crest derivatives expressed 2 1.13
B3GAT1 beta-1,3-glucuronyltransferase 1 1.117
PXDNL peroxidasin-like 1.11
PXDN peroxidasin 1.109
AFP alpha-fetoprotein 1.108
ERAS ES cell expressed Ras 1.104
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 1.101
NBPF1 neuroblastoma breakpoint family, member 1 1.1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.099
SAMD1 sterile alpha motif domain containing 1 1.098
BDNF brain-derived neurotrophic factor 1.097
YAP1 Yes-associated protein 1 1.096
DAXX death-domain associated protein 1.09
ACTB actin, beta 1.082
CD9 CD9 molecule 1.081
KDM4B lysine (K)-specific demethylase 4B 1.08
NEUROD6 neuronal differentiation 6 1.076
GAST gastrin 1.076
HCRT hypocretin (orexin) neuropeptide precursor 1.075
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.071
MEN1 multiple endocrine neoplasia I 1.07
SAMD15 sterile alpha motif domain containing 15 1.068
CALB2 calbindin 2 1.066
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 1.065
TLX2 T-cell leukemia homeobox 2 1.065
PAX3 paired box 3 1.052
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.048
MYOD1 myogenic differentiation 1 1.048
AVP arginine vasopressin 1.047
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.047
S100B S100 calcium binding protein B 1.046
CNTN5 contactin 5 1.046
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 1.045
KDM1A lysine (K)-specific demethylase 1A 1.044
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.043
WT1 Wilms tumor 1 1.041
NUTM1 NUT midline carcinoma, family member 1 1.031
EGFR epidermal growth factor receptor 1.03
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 1.03
OR5T1 olfactory receptor, family 5, subfamily T, member 1 1.029
NBAS neuroblastoma amplified sequence 1.028
KIF1B kinesin family member 1B 1.028
EPAS1 endothelial PAS domain protein 1 1.027
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.026
AURKA aurora kinase A 1.025
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.021
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.02
LRIT2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 1.02
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 1.019
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.018
SUFU suppressor of fused homolog (Drosophila) 1.013
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 1.013
CDK4 cyclin-dependent kinase 4 1.012
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 1.012
BCL2 B-cell CLL/lymphoma 2 1.011
NEU2 sialidase 2 (cytosolic sialidase) 1.006
NF2 neurofibromin 2 (merlin) 1.005