Ganglioneuroblastoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, and nodular.|A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea (MeSH).|A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular. (Experimental Factor Ontology, EFO_0000502)
External Link https://www.disgenet.org/browser/0/1/0/C0206718
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Genes

57 genes associated with the disease Ganglioneuroblastoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACTB actin, beta
ADRB3 adrenoceptor beta 3
ALK anaplastic lymphoma receptor tyrosine kinase
ASCL1 achaete-scute family bHLH transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CRH corticotropin releasing hormone
CUX1 cut-like homeobox 1
EDN3 endothelin 3
ERBB3 erb-b2 receptor tyrosine kinase 3
EWSR1 EWS RNA-binding protein 1
FGF8 fibroblast growth factor 8 (androgen-induced)
FUBP1 far upstream element (FUSE) binding protein 1
GALP galanin-like peptide
GAP43 growth associated protein 43
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GDNF glial cell derived neurotrophic factor
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIC1 hypermethylated in cancer 1
IL2RB interleukin 2 receptor, beta
INSM1 insulinoma-associated 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
KDM1A lysine (K)-specific demethylase 1A
KHSRP KH-type splicing regulatory protein
KIF1B kinesin family member 1B
LGALS3 lectin, galactoside-binding, soluble, 3
LGMN legumain
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO1H myosin IH
NCAM1 neural cell adhesion molecule 1
NGF nerve growth factor (beta polypeptide)
NPY neuropeptide Y
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PHOX2B paired-like homeobox 2b
PSIP1 PC4 and SFRS1 interacting protein 1
PTHLH parathyroid hormone-like hormone
RET ret proto-oncogene
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SST somatostatin
TAC1 tachykinin, precursor 1
TCF3 transcription factor 3
TH tyrosine hydroxylase
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2
UTS2 urotensin 2
VIP vasoactive intestinal peptide
WASF3 WAS protein family, member 3