Gastroparesis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

273 genes co-occuring with the disease Gastroparesis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MLN motilin 3.5
MLNR motilin receptor 3.383
GHRL ghrelin/obestatin prepropeptide 2.975
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.883
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.882
INS insulin 2.766
GHSR growth hormone secretagogue receptor 2.661
GCG glucagon 2.574
GET1 guided entry of tail-anchored proteins factor 1 2.501
GLP1R glucagon-like peptide 1 receptor 2.402
NOS1 nitric oxide synthase 1 (neuronal) 2.399
GAST gastrin 2.36
TAC1 tachykinin, precursor 1 2.272
VIP vasoactive intestinal peptide 2.26
ANO1 anoctamin 1, calcium activated chloride channel 2.241
ALB albumin 2.21
PPY pancreatic polypeptide 2.18
HMOX1 heme oxygenase 1 2.174
PYY peptide YY 2.171
CCK cholecystokinin 2.17
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.143
PCSK5 proprotein convertase subtilisin/kexin type 5 2.142
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.12
TACR1 tachykinin receptor 1 2.095
DPP4 dipeptidyl-peptidase 4 2.089
KITLG KIT ligand 2.085
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.077
SST somatostatin 2.059
CHAT choline O-acetyltransferase 2.039
GIP gastric inhibitory polypeptide 1.994
MRC1 mannose receptor, C type 1 1.986
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.967
DRD2 dopamine receptor D2 1.936
IAPP islet amyloid polypeptide 1.935
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.918
NPY neuropeptide Y 1.917
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.915
IL6 interleukin 6 1.89
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.88
CRP C-reactive protein, pentraxin-related 1.866
CCKAR cholecystokinin A receptor 1.838
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.833
TNF tumor necrosis factor 1.824
TTR transthyretin 1.821
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.815
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 1.807
LEP leptin 1.805
TH tyrosine hydroxylase 1.803
SCT secretin 1.788
IGF1 insulin-like growth factor 1 (somatomedin C) 1.786
MBOAT4 membrane bound O-acyltransferase domain containing 4 1.777
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.766
SI sucrase-isomaltase (alpha-glucosidase) 1.762
ACHE acetylcholinesterase (Yt blood group) 1.761
IL1B interleukin 1, beta 1.76
ELAVL3 ELAV like neuron-specific RNA binding protein 3 1.759
MGAM maltase-glucoamylase 1.751
HRH2 histamine receptor H2 1.726
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.717
ACE angiotensin I converting enzyme 1.703
GDNF glial cell derived neurotrophic factor 1.668
POMC proopiomelanocortin 1.648
LIPN lipase, family member N 1.646
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.628
IL10 interleukin 10 1.626
SP6 Sp6 transcription factor 1.603
CCR10 chemokine (C-C motif) receptor 10 1.595
BCHE butyrylcholinesterase 1.588
OPRM1 opioid receptor, mu 1 1.583
CRH corticotropin releasing hormone 1.579
ELAVL4 ELAV like neuron-specific RNA binding protein 4 1.579
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.571
SOX10 SRY (sex determining region Y)-box 10 1.571
TYMP thymidine phosphorylase 1.555
OXT oxytocin/neurophysin I prepropeptide 1.554
ACTG2 actin, gamma 2, smooth muscle, enteric 1.55
MAOB monoamine oxidase B 1.529
FOS FBJ murine osteosarcoma viral oncogene homolog 1.529
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 1.516
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.515
NTS neurotensin 1.502
PRL prolactin 1.495
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.492
SMTN smoothelin 1.485
DPYSL5 dihydropyrimidinase-like 5 1.482
REN renin 1.47
AGRP agouti related neuropeptide 1.468
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.467
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.466
CCL28 chemokine (C-C motif) ligand 28 1.464
TPH1 tryptophan hydroxylase 1 1.46
S100B S100 calcium binding protein B 1.458
HMOX2 heme oxygenase 2 1.448
MYH11 myosin, heavy chain 11, smooth muscle 1.445
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1.428
TGM2 transglutaminase 2 1.426
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.424
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.423
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.42
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.413
ADRB2 adrenoceptor beta 2, surface 1.408
BDNF brain-derived neurotrophic factor 1.408
GAL galanin/GMAP prepropeptide 1.383
CD68 CD68 molecule 1.383
CELA1 chymotrypsin-like elastase family, member 1 1.383
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.379
NPR3 natriuretic peptide receptor 3 1.378
COMT catechol-O-methyltransferase 1.377
FABP2 fatty acid binding protein 2, intestinal 1.373
MYH14 myosin, heavy chain 14, non-muscle 1.368
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.367
MYLK myosin light chain kinase 1.366
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.366
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 1.364
POLG polymerase (DNA directed), gamma 1.358
PTPRC protein tyrosine phosphatase, receptor type, C 1.357
TGFB1 transforming growth factor, beta 1 1.354
TRH thyrotropin-releasing hormone 1.338
CD4 CD4 molecule 1.331
NGF nerve growth factor (beta polypeptide) 1.316
IFNG interferon, gamma 1.31
GH1 growth hormone 1 1.308
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.308
CELA3B chymotrypsin-like elastase family, member 3B 1.308
CARTPT CART prepropeptide 1.307
NXPH2 neurexophilin 2 1.307
EFCAB14 EF-hand calcium binding domain 14 1.304
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.297
CCL2 chemokine (C-C motif) ligand 2 1.287
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.286
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.282
HCRT hypocretin (orexin) neuropeptide precursor 1.281
SP9 Sp9 transcription factor 1.28
PTH parathyroid hormone 1.277
AMPH amphiphysin 1.277
CLCN2 chloride channel, voltage-sensitive 2 1.276
EPO erythropoietin 1.276
CXCL8 chemokine (C-X-C motif) ligand 8 1.271
ETV1 ets variant 1 1.269
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.262
DPP10 dipeptidyl-peptidase 10 (non-functional) 1.261
RNPC3 RNA-binding region (RNP1, RRM) containing 3 1.261
OCLN occludin 1.26
CALCB calcitonin-related polypeptide beta 1.26
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.254
TLR4 toll-like receptor 4 1.249
CNR1 cannabinoid receptor 1 (brain) 1.238
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.233
PDE5A phosphodiesterase 5A, cGMP-specific 1.23
COPA coatomer protein complex, subunit alpha 1.221
CLCA2 chloride channel accessory 2 1.216
MYO5A myosin VA (heavy chain 12, myoxin) 1.216
IL1A interleukin 1, alpha 1.214
DRD3 dopamine receptor D3 1.211
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.209
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.207
DPP6 dipeptidyl-peptidase 6 1.206
PHOX2B paired-like homeobox 2b 1.201
CALB2 calbindin 2 1.2
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 1.2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.196
ADIPOQ adiponectin, C1Q and collagen domain containing 1.194
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.193
KLF11 Kruppel-like factor 11 1.191
ADRA1D adrenoceptor alpha 1D 1.191
MAOA monoamine oxidase A 1.188
CALB1 calbindin 1, 28kDa 1.186
MRPL28 mitochondrial ribosomal protein L28 1.184
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 1.184
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.177
NFE2L2 nuclear factor, erythroid 2-like 2 1.17
CSH2 chorionic somatomammotropin hormone 2 1.169
CLCA4 chloride channel accessory 4 1.168
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.167
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.166
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.164
LIPF lipase, gastric 1.162
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.161
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.158
LEPR leptin receptor 1.157
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.157
GUCA2B guanylate cyclase activator 2B (uroguanylin) 1.154
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.152
IL4 interleukin 4 1.147
GUCY2C guanylate cyclase 2C 1.14
NPY1R neuropeptide Y receptor Y1 1.139
EDN1 endothelin 1 1.138
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.137
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.131
FFAR2 free fatty acid receptor 2 1.131
INSR insulin receptor 1.131
CALML4 calmodulin-like 4 1.13
CALML6 calmodulin-like 6 1.13
CALML3 calmodulin-like 3 1.128
CALML5 calmodulin-like 5 1.127
ACTB actin, beta 1.126
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 1.126
BIN1 bridging integrator 1 1.123
GLP2R glucagon-like peptide 2 receptor 1.122
GH2 growth hormone 2 1.122
TJP1 tight junction protein 1 1.12
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.118
GPBAR1 G protein-coupled bile acid receptor 1 1.116
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.115
GFAP glial fibrillary acidic protein 1.114
ANO2 anoctamin 2, calcium activated chloride channel 1.111
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.11
PRSS58 protease, serine, 58 1.109
PRSS1 protease, serine, 1 (trypsin 1) 1.107
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.104
DNAH8 dynein, axonemal, heavy chain 8 1.104
CD8A CD8a molecule 1.103
PPARG peroxisome proliferator-activated receptor gamma 1.101
IL17A interleukin 17A 1.094
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.09
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.086
EGF epidermal growth factor 1.084
OXTR oxytocin receptor 1.083
CLCA1 chloride channel accessory 1 1.082
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 1.082
GFRA1 GDNF family receptor alpha 1 1.08
JUN jun proto-oncogene 1.079
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.078
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.075
AVP arginine vasopressin 1.068
NCOA2 nuclear receptor coactivator 2 1.067
SGO1 shugoshin 1 1.067
GCH1 GTP cyclohydrolase 1 1.061
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.058
MPO myeloperoxidase 1.058
PXDNL peroxidasin-like 1.057
MC4R melanocortin 4 receptor 1.057
UCN2 urocortin 2 1.056
CSF1 colony stimulating factor 1 (macrophage) 1.055
CALCRL calcitonin receptor-like 1.053
UCN urocortin 1.052
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.05
GPR55 G protein-coupled receptor 55 1.05
FOXF2 forkhead box F2 1.05
F2 coagulation factor II (thrombin) 1.049
NRTN neurturin 1.048
NOS3 nitric oxide synthase 3 (endothelial cell) 1.047
EDNRB endothelin receptor type B 1.045
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.044
PXDN peroxidasin 1.037
ACE2 angiotensin I converting enzyme 2 1.034
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.028
CKMT1B creatine kinase, mitochondrial 1B 1.027
IL2 interleukin 2 1.027
CKB creatine kinase, brain 1.025
ARRB2 arrestin, beta 2 1.024
CKM creatine kinase, muscle 1.023
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.021
PNMA2 paraneoplastic Ma antigen 2 1.02
SCN5A sodium channel, voltage gated, type V alpha subunit 1.02
CHGA chromogranin A 1.02
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.019
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.019
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.018
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.018
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.016
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.016
TLR2 toll-like receptor 2 1.015
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.015
PLP1 proteolipid protein 1 1.01
GPR119 G protein-coupled receptor 119 1.01
NPPB natriuretic peptide B 1.008
ESR2 estrogen receptor 2 (ER beta) 1.007
ARG1 arginase 1 1.007
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.006
EDN3 endothelin 3 1.001
PRKG1 protein kinase, cGMP-dependent, type I 1.001
SYP synaptophysin 1.0