| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/123631 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Gefitinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PAH | phenylalanine hydroxylase | 1.32 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.23 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.13 |
| GJB3 | gap junction protein, beta 3, 31kDa | 1.04 |
| LAMC2 | laminin, gamma 2 | 0.95 |
| APOB | apolipoprotein B | 0.95 |
| CALB2 | calbindin 2 | 0.88 |
| HBB | hemoglobin, beta | 0.88 |
| HAS3 | hyaluronan synthase 3 | 0.86 |
| SLC38A2 | solute carrier family 38, member 2 | 0.84 |
| LDLR | low density lipoprotein receptor | 0.72 |
| JUN | jun proto-oncogene | 0.72 |
| NIBAN1 | niban apoptosis regulator 1 | 0.71 |
| TSPAN3 | tetraspanin 3 | 0.69 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.67 |
| TNS4 | tensin 4 | 0.67 |
| NRP1 | neuropilin 1 | 0.66 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.66 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.65 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.64 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 0.63 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.61 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.6 |
| SLX4 | SLX4 structure-specific endonuclease subunit | 0.6 |
| ITM2C | integral membrane protein 2C | 0.59 |
| UPP1 | uridine phosphorylase 1 | 0.58 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 0.57 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.56 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.56 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.55 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.55 |
| ADPRHL1 | ADP-ribosylhydrolase like 1 | 0.55 |
| SLFN5 | schlafen family member 5 | 0.54 |
| FAM122A | family with sequence similarity 122A | 0.54 |
| PAQR4 | progestin and adipoQ receptor family member IV | 0.53 |
| TMEM222 | transmembrane protein 222 | 0.53 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.53 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.52 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.52 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | 0.52 |
| DUSP4 | dual specificity phosphatase 4 | 0.51 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.51 |
| PRNP | prion protein | 0.51 |
| IFRD1 | interferon-related developmental regulator 1 | 0.51 |
| TRIM2 | tripartite motif containing 2 | 0.5 |
| IGSF8 | immunoglobulin superfamily, member 8 | 0.5 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.5 |
| ITGB4 | integrin, beta 4 | 0.49 |
| CENPH | centromere protein H | 0.49 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.48 |
| AKNA | AT-hook transcription factor | 0.47 |
| ACVR2A | activin A receptor, type IIA | 0.47 |
| HGFAC | HGF activator | 0.47 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.47 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.47 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.46 |
| SQLE | squalene epoxidase | 0.46 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.46 |
| MT1X | metallothionein 1X | 0.46 |
| ZFHX3 | zinc finger homeobox 3 | 0.46 |
| LAMA5 | laminin, alpha 5 | 0.45 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.45 |
| H1-5 | H1.5 linker histone, cluster member | 0.44 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.44 |
| ITGA6 | integrin, alpha 6 | 0.44 |
| PSPH | phosphoserine phosphatase | 0.44 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.43 |
| CCDC91 | coiled-coil domain containing 91 | 0.43 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.43 |
| ABHD2 | abhydrolase domain containing 2 | 0.43 |
| FRRS1 | ferric-chelate reductase 1 | 0.43 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.43 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.42 |
| ZMYM6 | zinc finger, MYM-type 6 | 0.42 |
| PLAUR | plasminogen activator, urokinase receptor | 0.42 |
| PLPP3 | phospholipid phosphatase 3 | 0.42 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.42 |
| ENKD1 | enkurin domain containing 1 | 0.42 |
| PYGB | phosphorylase, glycogen; brain | 0.42 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.42 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.42 |
| STC2 | stanniocalcin 2 | 0.42 |
| POMT1 | protein-O-mannosyltransferase 1 | 0.41 |
| H1-0 | H1.0 linker histone | 0.41 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.41 |
| FOSL1 | FOS-like antigen 1 | 0.41 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.41 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.41 |
| PLAU | plasminogen activator, urokinase | 0.41 |
| TMEM231 | transmembrane protein 231 | 0.41 |
| TMEM189 | transmembrane protein 189 | 0.41 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 0.4 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.4 |
| KLC1 | kinesin light chain 1 | 0.4 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.4 |
| C19ORF54 | chromosome 19 open reading frame 54 | 0.4 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.4 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.4 |
| SGMS2 | sphingomyelin synthase 2 | 0.4 |
| ZNF518A | zinc finger protein 518A | 0.4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.3 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -1.09 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -1.0 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.98 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | -0.8 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | -0.79 |
| AXIN2 | axin 2 | -0.73 |
| GPN2 | GPN-loop GTPase 2 | -0.71 |
| SIRT2 | sirtuin 2 | -0.71 |
| SYTL2 | synaptotagmin-like 2 | -0.62 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.6 |
| ODC1 | ornithine decarboxylase 1 | -0.58 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.58 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.57 |
| LRRC58 | leucine rich repeat containing 58 | -0.55 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.55 |
| MIDN | midnolin | -0.54 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.53 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.53 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | -0.52 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.52 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | -0.52 |
| B2M | beta-2-microglobulin | -0.51 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.51 |
| ZNF320 | zinc finger protein 320 | -0.49 |
| PROCR | protein C receptor, endothelial | -0.48 |
| SNAP47 | synaptosomal-associated protein, 47kDa | -0.47 |
| CCDC115 | coiled-coil domain containing 115 | -0.47 |
| ZNF623 | zinc finger protein 623 | -0.47 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.46 |
| PIP | prolactin-induced protein | -0.46 |
| AMACR | alpha-methylacyl-CoA racemase | -0.46 |
| JMJD4 | jumonji domain containing 4 | -0.46 |
| HOMEZ | homeobox and leucine zipper encoding | -0.46 |
| SPHK2 | sphingosine kinase 2 | -0.45 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.45 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.44 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.44 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.44 |
| AGFG2 | ArfGAP with FG repeats 2 | -0.44 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.43 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.43 |
| IER5L | immediate early response 5-like | -0.43 |
| ZNF76 | zinc finger protein 76 | -0.42 |
| DUSP22 | dual specificity phosphatase 22 | -0.42 |
| NAAA | N-acylethanolamine acid amidase | -0.42 |
| MTPN | myotrophin | -0.42 |
| RWDD3 | RWD domain containing 3 | -0.42 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.41 |
| TMEM177 | transmembrane protein 177 | -0.41 |
| S100A2 | S100 calcium binding protein A2 | -0.41 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.41 |
| OSCP1 | organic solute carrier partner 1 | -0.41 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.41 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -0.41 |
| LRRC45 | leucine rich repeat containing 45 | -0.41 |
| ANKRD39 | ankyrin repeat domain 39 | -0.41 |
| TTYH3 | tweety family member 3 | -0.41 |
| SP110 | SP110 nuclear body protein | -0.4 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | -0.4 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.4 |
| ATE1 | arginyltransferase 1 | -0.4 |
| BAIAP2 | BAI1-associated protein 2 | -0.4 |
| KDF1 | keratinocyte differentiation factor 1 | -0.4 |
| LDHD | lactate dehydrogenase D | -0.39 |
| CDK4 | cyclin-dependent kinase 4 | -0.39 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.39 |
| ZNF337 | zinc finger protein 337 | -0.39 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.39 |
| TCTN3 | tectonic family member 3 | -0.39 |
| ZFP62 | ZFP62 zinc finger protein | -0.39 |
| MIEN1 | migration and invasion enhancer 1 | -0.39 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.38 |
| GPR161 | G protein-coupled receptor 161 | -0.38 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -0.38 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.38 |
| CYBRD1 | cytochrome b reductase 1 | -0.37 |
| CCDC57 | coiled-coil domain containing 57 | -0.37 |
| SDC1 | syndecan 1 | -0.37 |
| CGNL1 | cingulin-like 1 | -0.37 |
| AK6 | adenylate kinase 6 | -0.37 |
| ENO1 | enolase 1, (alpha) | -0.37 |
| CLTB | clathrin, light chain B | -0.36 |
| COPS4 | COP9 signalosome subunit 4 | -0.36 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.36 |
| MADD | MAP-kinase activating death domain | -0.36 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.36 |
| ZNF544 | zinc finger protein 544 | -0.35 |
| MBP | myelin basic protein | -0.35 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | -0.35 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.35 |
| PLK2 | polo-like kinase 2 | -0.35 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | -0.35 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | -0.34 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -0.34 |
| BOLA1 | bolA family member 1 | -0.34 |
| GLMP | glycosylated lysosomal membrane protein | -0.34 |
| RND3 | Rho family GTPase 3 | -0.34 |
| DOCK4 | dedicator of cytokinesis 4 | -0.34 |
| COMMD6 | COMM domain containing 6 | -0.33 |
