Gefitinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0967817
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0863166
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0627065
TRIO trio Rho guanine nucleotide exchange factor 0.0570951
FBN1 fibrillin 1 0.0504966
FNDC3B fibronectin type III domain containing 3B 0.0501204
SQSTM1 sequestosome 1 0.0479109
OGA O-GlcNAcase 0.0476645
TNIP1 TNFAIP3 interacting protein 1 0.0429737
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0411351
UBC ubiquitin C 0.0407591
SOD2 superoxide dismutase 2, mitochondrial 0.0403618
OPTN optineurin 0.0401758
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0401516
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0400899
CLU clusterin 0.0399153
MYH9 myosin, heavy chain 9, non-muscle 0.037697
ZFP36L1 ZFP36 ring finger protein-like 1 0.0372413
DST dystonin 0.0362542
GOLGA4 golgin A4 0.0361168
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0360465
LOXL2 lysyl oxidase-like 2 0.0359562
NFE2L1 nuclear factor, erythroid 2-like 1 0.0356144
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0349859
HELZ helicase with zinc finger 0.0348547
NAV2 neuron navigator 2 0.0347666
AKAP12 A kinase (PRKA) anchor protein 12 0.0337495
KLF7 Kruppel-like factor 7 (ubiquitous) 0.033239
ADM adrenomedullin 0.0322126
CYLD cylindromatosis (turban tumor syndrome) 0.0322058
NDRG1 N-myc downstream regulated 1 0.0319566
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0318998
LDHA lactate dehydrogenase A 0.031874
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303023
CD109 CD109 molecule 0.0302961
IQGAP1 IQ motif containing GTPase activating protein 1 0.0299462
ESYT2 extended synaptotagmin-like protein 2 0.0299016
DPYSL3 dihydropyrimidinase-like 3 0.0286516
FLNB filamin B, beta 0.0283352
DSCAM Down syndrome cell adhesion molecule 0.0282776
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0273135
MXI1 MAX interactor 1, dimerization protein 0.0271321
HILPDA hypoxia inducible lipid droplet-associated 0.0267526
GLS2 glutaminase 2 (liver, mitochondrial) 0.0264709
VEGFA vascular endothelial growth factor A 0.026467
SPAG9 sperm associated antigen 9 0.0261993
SETD5 SET domain containing 5 0.0260979
FMNL2 formin-like 2 0.0260619
EEF2 eukaryotic translation elongation factor 2 0.0257304
WDFY1 WD repeat and FYVE domain containing 1 0.0256964
MMP12 matrix metallopeptidase 12 0.0252786
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0247519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0247059
XPO1 exportin 1 0.0241963
KMT2C lysine (K)-specific methyltransferase 2C 0.0241591
SBF2 SET binding factor 2 0.0240716
ATP13A3 ATPase type 13A3 0.0237046
FAM107B family with sequence similarity 107, member B 0.0236122
ZMIZ1 zinc finger, MIZ-type containing 1 0.0235638
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0235581
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0234829
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0234769
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0232512
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0232225
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0231795
MIMS1 mitochondrial inner membrane scaffold 1 0.0230427
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0229364
ADAM9 ADAM metallopeptidase domain 9 0.0226624
PRRC2C proline-rich coiled-coil 2C 0.0224835
ADAM17 ADAM metallopeptidase domain 17 0.0224776
C1D C1D nuclear receptor corepressor 0.0224166
NAMPT nicotinamide phosphoribosyltransferase 0.0223535
SUCO SUN domain containing ossification factor 0.0222119
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0221801
RICTOR RPTOR independent companion of MTOR, complex 2 0.02206
MSN moesin 0.0219458
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0218209
RNMT RNA (guanine-7-) methyltransferase 0.0217148
KDM3A lysine (K)-specific demethylase 3A 0.0215015
KMT2E lysine (K)-specific methyltransferase 2E 0.021384
AUTS2 autism susceptibility candidate 2 0.0213139
RTN4 reticulon 4 0.0211794
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0211315
SOX9 SRY (sex determining region Y)-box 9 0.0210181
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0209331
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0209079
TRA2A transformer 2 alpha homolog (Drosophila) 0.0204611
KDM6A lysine (K)-specific demethylase 6A 0.0203689
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203338
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0203189
ARRDC3 arrestin domain containing 3 0.0201706
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0201076
DDIT4 DNA-damage-inducible transcript 4 0.0199256
RAB1A RAB1A, member RAS oncogene family 0.0198365
TSC22D2 TSC22 domain family, member 2 0.0197234
NT5C2 5'-nucleotidase, cytosolic II 0.0194745
KLF6 Kruppel-like factor 6 0.019392
PICALM phosphatidylinositol binding clathrin assembly protein 0.0192274
SDK1 sidekick cell adhesion molecule 1 0.0191802
YEATS2 YEATS domain containing 2 0.019155

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.157896
TMSB10 thymosin beta 10 -0.153803
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0909718
PODXL podocalyxin-like -0.0845002
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0811496
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0799922
S100A10 S100 calcium binding protein A10 -0.0786576
CDH13 cadherin 13 -0.0783489
SUCNR1 succinate receptor 1 -0.0680588
IGFBP3 insulin-like growth factor binding protein 3 -0.0665497
AHNAK AHNAK nucleoprotein -0.0662596
S100A6 S100 calcium binding protein A6 -0.0645239
PLAT plasminogen activator, tissue -0.0590486
NAV1 neuron navigator 1 -0.053541
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0466116
SLC39A11 solute carrier family 39, member 11 -0.046287
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0445317
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0425198
FN1 fibronectin 1 -0.0416642
MT2A metallothionein 2A -0.040216
CSTB cystatin B (stefin B) -0.0396222
EFNA5 ephrin-A5 -0.0394773
MAP1B microtubule-associated protein 1B -0.0381774
FRMD4A FERM domain containing 4A -0.0354475
LOX lysyl oxidase -0.0348735
PRSS23 protease, serine, 23 -0.0346676
TPM4 tropomyosin 4 -0.0321463
TPT1 tumor protein, translationally-controlled 1 -0.0317702
SLC38A1 solute carrier family 38, member 1 -0.0307436
TMSB4X thymosin beta 4, X-linked -0.0306501
LRRC17 leucine rich repeat containing 17 -0.0305838
HLA-B major histocompatibility complex, class I, B -0.0304959
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0304263
CAVIN1 caveolae associated protein 1 -0.0303895
RPS24 ribosomal protein S24 -0.0303546
ASPH aspartate beta-hydroxylase -0.0299892
LOC112694756 uncharaterized LOC112694756 -0.0292597
TUBB4B tubulin, beta 4B class IVb -0.0291254
ABI3BP ABI family, member 3 (NESH) binding protein -0.0284874
SAMD9 sterile alpha motif domain containing 9 -0.0269092
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0259381
S100A4 S100 calcium binding protein A4 -0.0251045
CD59 CD59 molecule, complement regulatory protein -0.0250598
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0248839
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0248559
LMNA lamin A/C -0.0246474
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0243752
SORBS2 sorbin and SH3 domain containing 2 -0.0240797
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0239815
DGKG diacylglycerol kinase, gamma 90kDa -0.0236481
HLA-C major histocompatibility complex, class I, C -0.0233278
FLT1 fms-related tyrosine kinase 1 -0.0229885
ISG15 ISG15 ubiquitin-like modifier -0.0228109
MX2 MX dynamin-like GTPase 2 -0.0223597
IFI6 interferon, alpha-inducible protein 6 -0.0223036
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.02227
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0222003
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0221086
NT5E 5'-nucleotidase, ecto (CD73) -0.0219107
EGFR epidermal growth factor receptor -0.0215628
RIGI RNA sensor RIG-I -0.0212688
RPL35A ribosomal protein L35a -0.0206195
KRT81 keratin 81, type II -0.0204665
AHNAK2 AHNAK nucleoprotein 2 -0.0192786
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0191392
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0189867
RPLP1 ribosomal protein, large, P1 -0.0189443
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.018882
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0188682
GLIS3 GLIS family zinc finger 3 -0.0185814
RPL23 ribosomal protein L23 -0.0184515
IFITM3 interferon induced transmembrane protein 3 -0.0183937
HSPB1 heat shock 27kDa protein 1 -0.0183209
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0179663
SPDL1 spindle apparatus coiled-coil protein 1 -0.0178352
S100A11 S100 calcium binding protein A11 -0.0177173
CAPN2 calpain 2, (m/II) large subunit -0.017692
CEP170 centrosomal protein 170kDa -0.0176838
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0175145
OSMR oncostatin M receptor -0.0174933
SMC4 structural maintenance of chromosomes 4 -0.0174479
TBCA tubulin folding cofactor A -0.0171271
RPL37A ribosomal protein L37a -0.0166356
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0165916
RPL34 ribosomal protein L34 -0.0165339
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0163379
PBX3 pre-B-cell leukemia homeobox 3 -0.0162571
KPNB1 karyopherin (importin) beta 1 -0.0161427
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0160556
CEP112 centrosomal protein 112kDa -0.0159036
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.015903
ZNF217 zinc finger protein 217 -0.0158887
RPS15 ribosomal protein S15 -0.0158755
HOXD10 homeobox D10 -0.0158379
COL5A1 collagen, type V, alpha 1 -0.0157836
CCND1 cyclin D1 -0.0156292
CUX1 cut-like homeobox 1 -0.0155381
CYTH3 cytohesin 3 -0.0155252
RPL28 ribosomal protein L28 -0.0155037