Gefitinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.105022
AKAP12 A kinase (PRKA) anchor protein 12 0.0704888
FAM13A family with sequence similarity 13, member A 0.0612931
KDM3A lysine (K)-specific demethylase 3A 0.0603075
HELZ helicase with zinc finger 0.0595482
FNDC3B fibronectin type III domain containing 3B 0.0538532
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0477375
DSCAM Down syndrome cell adhesion molecule 0.0472018
ZSWIM6 zinc finger, SWIM-type containing 6 0.0456424
WAC WW domain containing adaptor with coiled-coil 0.0427905
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0404593
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.036801
VMP1 vacuole membrane protein 1 0.0361103
VEGFA vascular endothelial growth factor A 0.0357478
OGA O-GlcNAcase 0.0345826
TLE4 transducin-like enhancer of split 4 0.0332265
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0328975
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0324827
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0319137
COPA coatomer protein complex, subunit alpha 0.0317408
INTS6 integrator complex subunit 6 0.0314821
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0309528
NFE2L1 nuclear factor, erythroid 2-like 1 0.0295864
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.029539
GPBP1 GC-rich promoter binding protein 1 0.0286169
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0284641
TENT5A terminal nucleotidyltransferase 5A 0.0283629
SOX9 SRY (sex determining region Y)-box 9 0.027607
FERMT2 fermitin family member 2 0.0273731
CASC3 cancer susceptibility candidate 3 0.0269723
HILPDA hypoxia inducible lipid droplet-associated 0.0262835
NUP58 nucleoporin 58 0.0262216
FXR1 fragile X mental retardation, autosomal homolog 1 0.0244286
NPEPPS aminopeptidase puromycin sensitive 0.0236773
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0236429
PDLIM5 PDZ and LIM domain 5 0.0235114
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0233221
USP9X ubiquitin specific peptidase 9, X-linked 0.0230691
ZMAT3 zinc finger, matrin-type 3 0.0224926
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.022397
USP15 ubiquitin specific peptidase 15 0.0223005
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.022297
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222116
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0221354
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.022125
ZC3H11A zinc finger CCCH-type containing 11A 0.0221175
PDIA6 protein disulfide isomerase family A, member 6 0.0217942
HOOK2 hook microtubule-tethering protein 2 0.0217402
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0217372
SETD5 SET domain containing 5 0.0216882
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0215958
ANXA2 annexin A2 0.0215466
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0215347
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0214679
BIRC2 baculoviral IAP repeat containing 2 0.0214187
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0210378
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0210019
PDIA3 protein disulfide isomerase family A, member 3 0.0200976
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0198724
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0198168
DST dystonin 0.0196354
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0195543
RSRC2 arginine/serine-rich coiled-coil 2 0.0195496
DDIT4 DNA-damage-inducible transcript 4 0.0194342
EIF4B eukaryotic translation initiation factor 4B 0.0194121
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0192817
SENP6 SUMO1/sentrin specific peptidase 6 0.0192603
MARCHF6 membrane associated ring-CH-type finger 6 0.0190101
TMED2 transmembrane emp24 domain trafficking protein 2 0.0188684
ENAH enabled homolog (Drosophila) 0.0187847
ZMIZ1 zinc finger, MIZ-type containing 1 0.0183597
HSPA8 heat shock 70kDa protein 8 0.0183044
GOLGA4 golgin A4 0.0181936
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0181762
SRP54 signal recognition particle 54kDa 0.0180694
AFF4 AF4/FMR2 family, member 4 0.0180356
CTNND1 catenin (cadherin-associated protein), delta 1 0.0180068
WDR49 WD repeat domain 49 0.0173601
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0173461
MED13 mediator complex subunit 13 0.0173402
EP300 E1A binding protein p300 0.0172352
PTK2 protein tyrosine kinase 2 0.0171897
RAP1B RAP1B, member of RAS oncogene family 0.0171441
SEC31A SEC31 homolog A (S. cerevisiae) 0.0171233
HOMER1 homer scaffolding protein 1 0.0170371
DTNA dystrobrevin, alpha 0.0170108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0169523
TOB1 transducer of ERBB2, 1 0.0169212
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0169191
KMT2C lysine (K)-specific methyltransferase 2C 0.0168976
YTHDC1 YTH domain containing 1 0.0168739
TP53BP1 tumor protein p53 binding protein 1 0.01686
MEMO1 mediator of cell motility 1 0.0166858
SEC24D SEC24 family member D 0.0166498
DDR2 discoidin domain receptor tyrosine kinase 2 0.0166162
ACIN1 apoptotic chromatin condensation inducer 1 0.0165613
PEAK1 pseudopodium-enriched atypical kinase 1 0.016521
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0164798
SUCO SUN domain containing ossification factor 0.0164728
GLCCI1 glucocorticoid induced 1 0.0164661

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.222845
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182846
NRG1 neuregulin 1 -0.166453
LSAMP limbic system-associated membrane protein -0.162157
NALF1 NALCN channel auxiliary factor 1 -0.104648
RPL35A ribosomal protein L35a -0.0935435
RPS6 ribosomal protein S6 -0.0893811
TRIO trio Rho guanine nucleotide exchange factor -0.0876497
RPL23 ribosomal protein L23 -0.0834309
BCAS3 breast carcinoma amplified sequence 3 -0.0747706
PTPRD protein tyrosine phosphatase, receptor type, D -0.0726305
SYT1 synaptotagmin I -0.0721646
IGF2 insulin-like growth factor 2 -0.0659179
COL1A1 collagen, type I, alpha 1 -0.0653653
RPL19 ribosomal protein L19 -0.0653559
IFI16 interferon, gamma-inducible protein 16 -0.0651692
RPL38 ribosomal protein L38 -0.0637598
ACTG1 actin gamma 1 -0.0628744
RPLP1 ribosomal protein, large, P1 -0.0621578
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0620696
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0610609
VIM vimentin -0.0609205
B2M beta-2-microglobulin -0.0592129
BPTF bromodomain PHD finger transcription factor -0.0584168
TMSB10 thymosin beta 10 -0.0533083
TPT1 tumor protein, translationally-controlled 1 -0.050805
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0491775
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0484085
KLHL13 kelch-like family member 13 -0.0481629
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0481064
RPS24 ribosomal protein S24 -0.0447027
TRIB2 tribbles pseudokinase 2 -0.0442346
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0438423
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0422096
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0404311
RPL37A ribosomal protein L37a -0.0402726
ZBTB20 zinc finger and BTB domain containing 20 -0.0398187
THSD4 thrombospondin, type I, domain containing 4 -0.0393297
TBX2 T-box 2 -0.0388871
PDE4D phosphodiesterase 4D, cAMP-specific -0.0380681
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0376675
PTMA prothymosin, alpha -0.0373557
GATA3 GATA binding protein 3 -0.0369649
KPNB1 karyopherin (importin) beta 1 -0.0366562
H3-3B H3.3 histone B -0.0364989
SMYD3 SET and MYND domain containing 3 -0.0364551
RPL26 ribosomal protein L26 -0.0363187
RNF213 ring finger protein 213 -0.035514
DNAH14 dynein, axonemal, heavy chain 14 -0.0354107
RPL34 ribosomal protein L34 -0.0349874
RPS19 ribosomal protein S19 -0.0347439
RPL12 ribosomal protein L12 -0.0340288
CUX1 cut-like homeobox 1 -0.0339687
NCAM2 neural cell adhesion molecule 2 -0.0339431
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0336391
DPH6 diphthamine biosynthesis 6 -0.0335663
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0334578
RPS14 ribosomal protein S14 -0.0334163
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0332355
EIF1 eukaryotic translation initiation factor 1 -0.0331991
DCAF7 DDB1 and CUL4 associated factor 7 -0.032803
ANGPT1 angiopoietin 1 -0.0325532
RPL32 ribosomal protein L32 -0.0324239
BICD1 bicaudal D homolog 1 (Drosophila) -0.0321711
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0317538
CADM2 cell adhesion molecule 2 -0.0317372
HIP1 huntingtin interacting protein 1 -0.0315943
FTL ferritin, light polypeptide -0.0314997
FHIT fragile histidine triad -0.0312847
LPIN1 lipin 1 -0.031088
AOPEP aminopeptidase O (putative) -0.0309163
DLC1 DLC1 Rho GTPase activating protein -0.030727
PCDH9 protocadherin 9 -0.0302274
ZNF804A zinc finger protein 804A -0.0302179
GNAS GNAS complex locus -0.0301514
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0301009
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0298305
RBM20 RNA binding motif protein 20 -0.0295393
AHNAK AHNAK nucleoprotein -0.0294891
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0293467
NRP1 neuropilin 1 -0.0287969
FOXP1 forkhead box P1 -0.0287797
ANTXR1 anthrax toxin receptor 1 -0.0287356
S100A9 S100 calcium binding protein A9 -0.0286263
RPL31 ribosomal protein L31 -0.0284005
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.028387
RPS23 ribosomal protein S23 -0.0278455
KTN1 kinectin 1 (kinesin receptor) -0.027556
RPS21 ribosomal protein S21 -0.0275477
COL4A5 collagen, type IV, alpha 5 -0.0272288
RPS12 ribosomal protein S12 -0.0269273
RPS27 ribosomal protein S27 -0.0269119
EIF5B eukaryotic translation initiation factor 5B -0.0268889
EIF3A eukaryotic translation initiation factor 3, subunit A -0.026659
RPS15 ribosomal protein S15 -0.0264575
NREP neuronal regeneration related protein -0.0263902
GPATCH8 G patch domain containing 8 -0.0261771
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0258308
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0256799
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0255999