Gefitinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.126134
MACC1 metastasis associated in colon cancer 1 0.115114
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0854945
MYO1E myosin IE 0.0837985
NCKAP5 NCK-associated protein 5 0.0685327
STK24 serine/threonine kinase 24 0.060014
ZMYND8 zinc finger, MYND-type containing 8 0.0567752
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0511567
IFNGR1 interferon gamma receptor 1 0.0499071
EPS8 epidermal growth factor receptor pathway substrate 8 0.0481257
RUNX1 runt-related transcription factor 1 0.0477687
CCNL1 cyclin L1 0.0462463
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0459481
ARHGAP26 Rho GTPase activating protein 26 0.0452651
DSPP dentin sialophosphoprotein 0.0448459
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0441092
PTBP3 polypyrimidine tract binding protein 3 0.0435195
BTBD9 BTB (POZ) domain containing 9 0.0416683
ERBIN erbb2 interacting protein 0.0416381
NAMPT nicotinamide phosphoribosyltransferase 0.0414697
ZNF292 zinc finger protein 292 0.0405913
EXT1 exostosin glycosyltransferase 1 0.0405764
YAP1 Yes-associated protein 1 0.0402319
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0393303
XDH xanthine dehydrogenase 0.0391605
MEIS2 Meis homeobox 2 0.0385978
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0378291
DSCAM Down syndrome cell adhesion molecule 0.0377247
CXCL8 chemokine (C-X-C motif) ligand 8 0.0374038
FMN1 formin 1 0.0371971
FNIP2 folliculin interacting protein 2 0.0359854
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0358127
PRELID2 PRELI domain containing 2 0.0356533
ATXN1 ataxin 1 0.0343052
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0339792
SERINC5 serine incorporator 5 0.0339593
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0338052
RNF43 ring finger protein 43 0.0337133
FOXP1 forkhead box P1 0.0332606
ZBTB20 zinc finger and BTB domain containing 20 0.0331265
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0328118
RHOBTB3 Rho-related BTB domain containing 3 0.0326473
VMP1 vacuole membrane protein 1 0.0325212
TJP1 tight junction protein 1 0.0320401
AKAP13 A kinase (PRKA) anchor protein 13 0.0302364
ETNK1 ethanolamine kinase 1 0.0299756
AOPEP aminopeptidase O (putative) 0.0297642
PHF3 PHD finger protein 3 0.0288488
USP54 ubiquitin specific peptidase 54 0.0286042
PTEN phosphatase and tensin homolog 0.0285529
TOP2A topoisomerase (DNA) II alpha 170kDa 0.028534
NRIP1 nuclear receptor interacting protein 1 0.0282467
UBE2H ubiquitin-conjugating enzyme E2H 0.0282428
DENND4C DENN/MADD domain containing 4C 0.0278714
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0276802
ATP11A ATPase, class VI, type 11A 0.0273533
OCLN occludin 0.0273014
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0269566
ADAM10 ADAM metallopeptidase domain 10 0.0268525
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0264571
KLF3 Kruppel-like factor 3 (basic) 0.0263657
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0262838
ADD3 adducin 3 (gamma) 0.0261403
MTUS1 microtubule associated tumor suppressor 1 0.0258547
H1-0 H1.0 linker histone 0.025466
TRIM2 tripartite motif containing 2 0.0253947
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.025357
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0250974
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0250702
ARHGAP5 Rho GTPase activating protein 5 0.0250687
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0250173
PLAUR plasminogen activator, urokinase receptor 0.0249385
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0246839
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0244126
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0243541
ITGA6 integrin, alpha 6 0.0242447
SORBS1 sorbin and SH3 domain containing 1 0.0240242
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0240078
PRKCA protein kinase C, alpha 0.0239913
IGF2R insulin-like growth factor 2 receptor 0.0239014
MBNL2 muscleblind-like splicing regulator 2 0.0238885
MUC13 mucin 13, cell surface associated 0.0238486
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0234376
SPATA13 spermatogenesis associated 13 0.0234236
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0233735
PHACTR4 phosphatase and actin regulator 4 0.0229082
GSK3B glycogen synthase kinase 3 beta 0.0228321
B2M beta-2-microglobulin 0.0227532
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0226167
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0223572
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0221435
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0221414
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0221406
DUSP16 dual specificity phosphatase 16 0.0220506
SCAPER S-phase cyclin A-associated protein in the ER 0.0219888
NCOA2 nuclear receptor coactivator 2 0.0219244
FAT1 FAT atypical cadherin 1 0.0217702
TMEM62 transmembrane protein 62 0.0217055
DST dystonin 0.0215912
BCLAF1 BCL2-associated transcription factor 1 0.0213849

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0981366
INTS6 integrator complex subunit 6 -0.0666741
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0662504
RIGI RNA sensor RIG-I -0.0583724
PTMA prothymosin, alpha -0.0560157
EGR1 early growth response 1 -0.055344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502042
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0495626
LYZ lysozyme -0.0477695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0463444
RPL35A ribosomal protein L35a -0.0453218
PLSCR2 phospholipid scramblase 2 -0.0441784
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439039
IFI6 interferon, alpha-inducible protein 6 -0.0428762
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0389894
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0370255
MORF4L2 mortality factor 4 like 2 -0.0357411
RPL34 ribosomal protein L34 -0.0355843
MUC20 mucin 20, cell surface associated -0.0341735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0340319
TNS4 tensin 4 -0.0328496
TMSB10 thymosin beta 10 -0.0320131
RPLP1 ribosomal protein, large, P1 -0.031441
XAF1 XIAP associated factor 1 -0.0310421
FTL ferritin, light polypeptide -0.0305054
PKM pyruvate kinase, muscle -0.0293926
RPL23 ribosomal protein L23 -0.0281584
ANXA2 annexin A2 -0.0277644
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0270269
GCLC glutamate-cysteine ligase, catalytic subunit -0.0266372
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0262763
RPS8 ribosomal protein S8 -0.0258786
RPL19 ribosomal protein L19 -0.0258581
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0256532
ACTG1 actin gamma 1 -0.0251813
RNF213 ring finger protein 213 -0.0251732
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0250477
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0245739
GMDS GDP-mannose 4,6-dehydratase -0.0236984
RPS24 ribosomal protein S24 -0.0233751
CALR calreticulin -0.0231026
MAP7 microtubule-associated protein 7 -0.0229194
MT2A metallothionein 2A -0.0228612
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0228181
RPL37A ribosomal protein L37a -0.0227442
AGR2 anterior gradient 2 -0.0227356
NPSR1 neuropeptide S receptor 1 -0.0226865
EZR ezrin -0.0226069
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0222384
HLA-B major histocompatibility complex, class I, B -0.0221625
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0217901
RPS6 ribosomal protein S6 -0.0216887
S100A6 S100 calcium binding protein A6 -0.021638
CANX calnexin -0.0215243
RPL31 ribosomal protein L31 -0.0213884
VDAC1 voltage-dependent anion channel 1 -0.0212068
S100A10 S100 calcium binding protein A10 -0.0209723
HLA-C major histocompatibility complex, class I, C -0.020438
IER3 immediate early response 3 -0.0198456
GNAS GNAS complex locus -0.0197817
RPL37 ribosomal protein L37 -0.0194955
MX1 MX dynamin-like GTPase 1 -0.0194833
HM13 histocompatibility (minor) 13 -0.0190883
VCL vinculin -0.0190677
LOC112694756 uncharaterized LOC112694756 -0.018765
POU2F2 POU class 2 homeobox 2 -0.0185399
HMGB1 high mobility group box 1 -0.0182281
UGDH UDP-glucose 6-dehydrogenase -0.0182145
SP100 SP100 nuclear antigen -0.0177526
RPS19 ribosomal protein S19 -0.0177195
RPL12 ribosomal protein L12 -0.0175812
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0174579
RPL11 ribosomal protein L11 -0.0171748
UBAP2 ubiquitin associated protein 2 -0.0170626
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0170075
GOLPH3L golgi phosphoprotein 3-like -0.0168415
STS steroid sulfatase (microsomal), isozyme S -0.0162866
RPS27 ribosomal protein S27 -0.0161191
RPS3 ribosomal protein S3 -0.0157709
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0157421
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0156382
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0156266
IGFBP3 insulin-like growth factor binding protein 3 -0.0156055
RPS29 ribosomal protein S29 -0.0153925
RPS17 ribosomal protein S17 -0.0153786
TPM4 tropomyosin 4 -0.0153133
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0152275
ISG15 ISG15 ubiquitin-like modifier -0.0149884
MXD1 MAX dimerization protein 1 -0.0149278
PMP22 peripheral myelin protein 22 -0.0149263
SERP1 stress-associated endoplasmic reticulum protein 1 -0.0148144
TTC3 tetratricopeptide repeat domain 3 -0.0147904
RPL38 ribosomal protein L38 -0.0147584
S100A11 S100 calcium binding protein A11 -0.0146529
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0145751
POF1B premature ovarian failure, 1B -0.0145744
ZCCHC7 zinc finger, CCHC domain containing 7 -0.014444
MCL1 myeloid cell leukemia 1 -0.0143943
S100P S100 calcium binding protein P -0.0142276
POTEF POTE ankyrin domain family, member F -0.0141919