Gefitinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CLU clusterin 0.081434
LMO7 LIM domain 7 0.0623995
FOXO1 forkhead box O1 0.0476785
INTS6 integrator complex subunit 6 0.0379426
MSN moesin 0.0371622
CEMIP cell migration inducing protein, hyaluronan binding 0.0322745
FTH1 ferritin, heavy polypeptide 1 0.029436
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0292598
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277776
FNDC3B fibronectin type III domain containing 3B 0.0275508
GRB10 growth factor receptor-bound protein 10 0.0274929
ARHGAP21 Rho GTPase activating protein 21 0.0252757
KTN1 kinectin 1 (kinesin receptor) 0.0221367
ANKRD33B ankyrin repeat domain 33B 0.0219361
SEPTIN9 septin 9 0.0210547
TGM2 transglutaminase 2 0.0199653
N4BP2L2 NEDD4 binding protein 2-like 2 0.0194
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0193318
COG6 component of oligomeric golgi complex 6 0.0192174
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0188024
RBM39 RNA binding motif protein 39 0.0187608
MYOF myoferlin 0.018557
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0183955
ESYT2 extended synaptotagmin-like protein 2 0.0183789
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0182489
SQSTM1 sequestosome 1 0.0181939
GOLGA4 golgin A4 0.0180178
EXT1 exostosin glycosyltransferase 1 0.0179858
FNDC3A fibronectin type III domain containing 3A 0.0179117
KDM6A lysine (K)-specific demethylase 6A 0.0177967
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0174707
TRIO trio Rho guanine nucleotide exchange factor 0.0173466
OSMR oncostatin M receptor 0.0173062
SCFD1 sec1 family domain containing 1 0.0171897
USP34 ubiquitin specific peptidase 34 0.0169529
NRIP1 nuclear receptor interacting protein 1 0.0168601
STC1 stanniocalcin 1 0.0168482
RAP1B RAP1B, member of RAS oncogene family 0.0167907
LNPEP leucyl/cystinyl aminopeptidase 0.0167491
SMAD3 SMAD family member 3 0.0167017
AKAP9 A kinase (PRKA) anchor protein 9 0.0166179
TRIP12 thyroid hormone receptor interactor 12 0.016617
MBNL2 muscleblind-like splicing regulator 2 0.0165121
LIFR leukemia inhibitory factor receptor alpha 0.0164562
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0160939
ARRDC3 arrestin domain containing 3 0.0160397
CD46 CD46 molecule, complement regulatory protein 0.0160187
CUL4B cullin 4B 0.0157192
MBNL1 muscleblind-like splicing regulator 1 0.0155597
KIF16B kinesin family member 16B 0.0155545
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0154475
NCOA3 nuclear receptor coactivator 3 0.0153463
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0152201
SLC45A4 solute carrier family 45, member 4 0.0151423
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0149781
SERINC3 serine incorporator 3 0.0149125
PCDH1 protocadherin 1 0.0148941
RLIM ring finger protein, LIM domain interacting 0.0148342
PICALM phosphatidylinositol binding clathrin assembly protein 0.0146167
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0145457
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0143433
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0141709
EFNA5 ephrin-A5 0.0141632
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0140548
MT1E metallothionein 1E 0.0140271
SPAG9 sperm associated antigen 9 0.0139877
SAR1A secretion associated, Ras related GTPase 1A 0.0138685
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.013708
FN1 fibronectin 1 0.0136644
CTNND1 catenin (cadherin-associated protein), delta 1 0.0135375
CD44 CD44 molecule (Indian blood group) 0.0134682
DSCAM Down syndrome cell adhesion molecule 0.013334
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0131029
COPA coatomer protein complex, subunit alpha 0.0130185
SKAP2 src kinase associated phosphoprotein 2 0.0130031
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0129965
NUP98 nucleoporin 98kDa 0.0128221
PTK2 protein tyrosine kinase 2 0.0128069
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.012768
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0127641
ANO6 anoctamin 6 0.0127157
FNIP1 folliculin interacting protein 1 0.0125946
PRELID2 PRELI domain containing 2 0.0125879
OGA O-GlcNAcase 0.0124629
STAG2 stromal antigen 2 0.0124532
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0123061
KMT2C lysine (K)-specific methyltransferase 2C 0.0122727
KIF1B kinesin family member 1B 0.0122693
USP9X ubiquitin specific peptidase 9, X-linked 0.0122106
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0121836
ITPRID2 ITPR interacting domain containing 2 0.012174
LAMP2 lysosomal-associated membrane protein 2 0.0121635
HLA-E major histocompatibility complex, class I, E 0.0119301
RAB10 RAB10, member RAS oncogene family 0.0119089
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0119013
NDRG1 N-myc downstream regulated 1 0.0118613
CSDE1 cold shock domain containing E1, RNA-binding 0.0117767
DIAPH1 diaphanous-related formin 1 0.0117451
WDFY2 WD repeat and FYVE domain containing 2 0.0116904
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0116702

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.186326
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.112719
PTMA prothymosin, alpha -0.108276
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0591701
TMSB10 thymosin beta 10 -0.0476506
TPT1 tumor protein, translationally-controlled 1 -0.0422519
S100A10 S100 calcium binding protein A10 -0.0415396
HLA-B major histocompatibility complex, class I, B -0.039013
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0376927
RPLP1 ribosomal protein, large, P1 -0.0375661
IFI6 interferon, alpha-inducible protein 6 -0.0368834
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0347894
ZMYND8 zinc finger, MYND-type containing 8 -0.0345129
TMSB4X thymosin beta 4, X-linked -0.0332388
CAVIN1 caveolae associated protein 1 -0.031965
RPL35A ribosomal protein L35a -0.0302345
B2M beta-2-microglobulin -0.0301223
RPL26 ribosomal protein L26 -0.0295564
RPL36A ribosomal protein L36a -0.0288037
RPS21 ribosomal protein S21 -0.0287049
ACTG1 actin gamma 1 -0.0283884
RPS24 ribosomal protein S24 -0.0266592
HMGA2 high mobility group AT-hook 2 -0.025341
RPS6 ribosomal protein S6 -0.0241124
LOC112694756 uncharaterized LOC112694756 -0.0236295
IER3 immediate early response 3 -0.0229438
RPLP2 ribosomal protein, large, P2 -0.0227009
IGF2 insulin-like growth factor 2 -0.0224087
RPL8 ribosomal protein L8 -0.0217243
PODXL podocalyxin-like -0.0217038
RPL12 ribosomal protein L12 -0.0212173
SP100 SP100 nuclear antigen -0.0212008
RPL31 ribosomal protein L31 -0.0211184
RPL34 ribosomal protein L34 -0.0210507
ABI3BP ABI family, member 3 (NESH) binding protein -0.021027
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0208485
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0208133
DPYD dihydropyrimidine dehydrogenase -0.0207796
ZNFX1 zinc finger, NFX1-type containing 1 -0.0206814
GNAS GNAS complex locus -0.0205085
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0204189
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0200078
ANXA2 annexin A2 -0.0199721
SEPTIN7 septin 7 -0.0199652
WSB1 WD repeat and SOCS box containing 1 -0.0195069
ANO1 anoctamin 1, calcium activated chloride channel -0.0189892
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0188693
CUX1 cut-like homeobox 1 -0.0181792
MT2A metallothionein 2A -0.0177091
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0176369
RPS25 ribosomal protein S25 -0.0168883
HSPG2 heparan sulfate proteoglycan 2 -0.0168485
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0167501
RPS27A ribosomal protein S27a -0.0167415
F3 coagulation factor III (thromboplastin, tissue factor) -0.0167317
BLCAP bladder cancer associated protein -0.016682
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0163558
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0162524
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0161082
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0160336
TRIM56 tripartite motif containing 56 -0.015843
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0158171
VCL vinculin -0.0155948
PGK1 phosphoglycerate kinase 1 -0.0154226
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0153533
IFI16 interferon, gamma-inducible protein 16 -0.0153015
SLC35F3 solute carrier family 35, member F3 -0.0150492
H1-0 H1.0 linker histone -0.0149329
PPARG peroxisome proliferator-activated receptor gamma -0.0147745
AHNAK AHNAK nucleoprotein -0.0147264
YBX1 Y box binding protein 1 -0.0145232
MAML2 mastermind-like 2 (Drosophila) -0.0144283
CAV1 caveolin 1, caveolae protein, 22kDa -0.0144248
ZBTB7A zinc finger and BTB domain containing 7A -0.0143896
LMNA lamin A/C -0.0143439
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0143356
PKM pyruvate kinase, muscle -0.0141977
IFI44L interferon-induced protein 44-like -0.0140971
RND3 Rho family GTPase 3 -0.0140096
SAMD9L sterile alpha motif domain containing 9-like -0.0138512
PDE4D phosphodiesterase 4D, cAMP-specific -0.0135508
RAD51B RAD51 paralog B -0.0135018
TMEM165 transmembrane protein 165 -0.0134764
TXNRD1 thioredoxin reductase 1 -0.0133964
TM4SF1 transmembrane 4 L six family member 1 -0.0133753
RPL35 ribosomal protein L35 -0.0133465
COL5A2 collagen, type V, alpha 2 -0.0132407
XAF1 XIAP associated factor 1 -0.0131625
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0130602
MARCHF6 membrane associated ring-CH-type finger 6 -0.0130402
RPL36 ribosomal protein L36 -0.0130134
KDM3A lysine (K)-specific demethylase 3A -0.0129584
MYL12B myosin, light chain 12B, regulatory -0.0129506
RPL7A ribosomal protein L7a -0.0129286
S100A11 S100 calcium binding protein A11 -0.0128881
CALR calreticulin -0.0127916
NFIA nuclear factor I/A -0.0127757
CRACDL CRACD like -0.0127519
IFI44 interferon-induced protein 44 -0.0127247
RPS27 ribosomal protein S27 -0.0126554