Gefitinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.100625
LMO7 LIM domain 7 0.0818962
TXNIP thioredoxin interacting protein 0.0768417
EZR ezrin 0.0693044
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0667233
VEGFA vascular endothelial growth factor A 0.0631133
ITGA6 integrin, alpha 6 0.0567453
LDHA lactate dehydrogenase A 0.0540799
FAM13A family with sequence similarity 13, member A 0.0540423
DSPP dentin sialophosphoprotein 0.0533452
FAT1 FAT atypical cadherin 1 0.0487691
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0465112
ANXA1 annexin A1 0.0460546
EREG epiregulin 0.0448572
EPS8 epidermal growth factor receptor pathway substrate 8 0.0429215
EMP1 epithelial membrane protein 1 0.0423142
GOLGA4 golgin A4 0.0410785
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0407586
BAIAP2L1 BAI1-associated protein 2-like 1 0.0405851
FTH1 ferritin, heavy polypeptide 1 0.0401601
KMT2E lysine (K)-specific methyltransferase 2E 0.0386514
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0385879
MED13 mediator complex subunit 13 0.0383333
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0371801
RNF145 ring finger protein 145 0.0369133
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0368996
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0352832
LOC102724023 ES1 protein homolog, mitochondrial 0.0339565
MYO1E myosin IE 0.033751
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0337252
NDRG1 N-myc downstream regulated 1 0.0327529
ESYT2 extended synaptotagmin-like protein 2 0.0325114
SEC31A SEC31 homolog A (S. cerevisiae) 0.0324723
PTMA prothymosin, alpha 0.0323436
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0312514
ANKRD11 ankyrin repeat domain 11 0.0308401
WAC WW domain containing adaptor with coiled-coil 0.0308358
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0307279
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0306413
WDR45B WD repeat domain 45B 0.0305233
COPA coatomer protein complex, subunit alpha 0.0299799
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0296591
AFF1 AF4/FMR2 family, member 1 0.029552
IARS1 isoleucyl-tRNA synthetase 1 0.0293391
OGA O-GlcNAcase 0.0292186
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0284891
ANXA2 annexin A2 0.0284222
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.028087
MYO5B myosin VB 0.027463
UBA6 ubiquitin-like modifier activating enzyme 6 0.0268478
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0267229
TFG TRK-fused gene 0.026301
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0256686
NUP58 nucleoporin 58 0.0256113
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0255203
RBM39 RNA binding motif protein 39 0.0254384
DSCAM Down syndrome cell adhesion molecule 0.0254074
EEF2 eukaryotic translation elongation factor 2 0.0253665
SETD5 SET domain containing 5 0.0250501
KDM3A lysine (K)-specific demethylase 3A 0.0250397
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0250301
NCOR1 nuclear receptor corepressor 1 0.0249918
UGCG UDP-glucose ceramide glucosyltransferase 0.0247406
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0246538
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.024568
COG5 component of oligomeric golgi complex 5 0.0243992
LIPH lipase, member H 0.0240658
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0240409
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240111
PICALM phosphatidylinositol binding clathrin assembly protein 0.0239984
DDIT4 DNA-damage-inducible transcript 4 0.0238895
PARD3 par-3 family cell polarity regulator 0.0238265
RPL3 ribosomal protein L3 0.0237607
ZFAND3 zinc finger, AN1-type domain 3 0.0237442
USP6NL USP6 N-terminal like 0.0237309
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0235344
TES testin LIM domain protein 0.0232305
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0230352
KDM6A lysine (K)-specific demethylase 6A 0.0228423
MACF1 microtubule-actin crosslinking factor 1 0.0227911
FNBP1L formin binding protein 1-like 0.0227378
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0227362
ITPRID2 ITPR interacting domain containing 2 0.022681
PUM2 pumilio RNA-binding family member 2 0.0226728
ANKRD17 ankyrin repeat domain 17 0.0224557
CD2AP CD2-associated protein 0.0223555
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0223252
HELZ helicase with zinc finger 0.0222499
NCKAP1 NCK-associated protein 1 0.0218614
TTC3 tetratricopeptide repeat domain 3 0.0217983
KLF6 Kruppel-like factor 6 0.0217609
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0215217
LAMA4 laminin, alpha 4 0.0214786
RSRC2 arginine/serine-rich coiled-coil 2 0.0206377
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0206357
VMP1 vacuole membrane protein 1 0.0206142
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.020614
USP3 ubiquitin specific peptidase 3 0.0204216
ATF3 activating transcription factor 3 0.0201602
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0198734

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.144326
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102446
NPSR1 neuropeptide S receptor 1 -0.0971851
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0768843
RPL35A ribosomal protein L35a -0.0749423
RPLP1 ribosomal protein, large, P1 -0.0646794
RPS19 ribosomal protein S19 -0.0626407
CEMIP cell migration inducing protein, hyaluronan binding -0.0578847
RPL23 ribosomal protein L23 -0.0541048
TNS4 tensin 4 -0.0537596
RPLP2 ribosomal protein, large, P2 -0.053198
RPS6 ribosomal protein S6 -0.051784
RPS8 ribosomal protein S8 -0.0507774
RPL34 ribosomal protein L34 -0.0447933
RPL36 ribosomal protein L36 -0.0444665
FTL ferritin, light polypeptide -0.0443386
RPL12 ribosomal protein L12 -0.043727
TPT1 tumor protein, translationally-controlled 1 -0.0435772
NALF1 NALCN channel auxiliary factor 1 -0.0431899
ONECUT3 one cut homeobox 3 -0.0403032
CADPS Ca++-dependent secretion activator -0.0382826
FHIT fragile histidine triad -0.0380961
RPS24 ribosomal protein S24 -0.0372295
RPL9 ribosomal protein L9 -0.0364598
AHNAK AHNAK nucleoprotein -0.0363221
CCND1 cyclin D1 -0.0354345
HMGB1 high mobility group box 1 -0.0350851
RPS29 ribosomal protein S29 -0.032334
RPL32 ribosomal protein L32 -0.0314758
RPS21 ribosomal protein S21 -0.0311259
RPL31 ribosomal protein L31 -0.0301962
ACTG1 actin gamma 1 -0.0293929
PDE4D phosphodiesterase 4D, cAMP-specific -0.0291854
ACTN4 actinin, alpha 4 -0.0289533
RPL11 ribosomal protein L11 -0.0286063
RPL28 ribosomal protein L28 -0.0277709
RAD51B RAD51 paralog B -0.027652
ZBTB20 zinc finger and BTB domain containing 20 -0.027392
S100A6 S100 calcium binding protein A6 -0.0262798
RPL35 ribosomal protein L35 -0.0261261
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.026075
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0258643
RPL19 ribosomal protein L19 -0.0256915
POTEF POTE ankyrin domain family, member F -0.0256056
RPL27 ribosomal protein L27 -0.0254309
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0253965
RPS25 ribosomal protein S25 -0.0253516
RPL37A ribosomal protein L37a -0.0252698
AGR2 anterior gradient 2 -0.024847
RPLP0 ribosomal protein, large, P0 -0.0247902
RPS14 ribosomal protein S14 -0.0242566
RPL38 ribosomal protein L38 -0.0241868
TUBB4B tubulin, beta 4B class IVb -0.0238254
RPS16 ribosomal protein S16 -0.0238115
RPL5 ribosomal protein L5 -0.0237847
RPS23 ribosomal protein S23 -0.0235241
VDAC1 voltage-dependent anion channel 1 -0.0232944
SMYD3 SET and MYND domain containing 3 -0.0231034
EIF5B eukaryotic translation initiation factor 5B -0.0225805
RPL37 ribosomal protein L37 -0.0223169
IER3 immediate early response 3 -0.0219451
S100A10 S100 calcium binding protein A10 -0.0218606
PTPRR protein tyrosine phosphatase, receptor type, R -0.021529
S100P S100 calcium binding protein P -0.0213244
LOC112694756 uncharaterized LOC112694756 -0.0211791
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0211633
GMDS GDP-mannose 4,6-dehydratase -0.0210545
RPS11 ribosomal protein S11 -0.0208425
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0205652
MT2A metallothionein 2A -0.0204341
FOSL1 FOS-like antigen 1 -0.0204261
RPS20 ribosomal protein S20 -0.0202641
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0202009
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0198872
RPL36A ribosomal protein L36a -0.0198347
NRXN3 neurexin 3 -0.0195716
ANTXR2 anthrax toxin receptor 2 -0.0195262
RPS15 ribosomal protein S15 -0.0194174
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0193432
RPL30 ribosomal protein L30 -0.019141
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.018768
VCL vinculin -0.0187519
RPS4X ribosomal protein S4, X-linked -0.0187071
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0184165
PKP4 plakophilin 4 -0.0183488
RPS27 ribosomal protein S27 -0.0183384
RPL26 ribosomal protein L26 -0.0183023
RPS17 ribosomal protein S17 -0.0182287
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0181908
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0180986
RPS5 ribosomal protein S5 -0.0179627
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.0179546
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0179484
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0177372
FAF1 Fas (TNFRSF6) associated factor 1 -0.0176492
FRMD5 FERM domain containing 5 -0.01761
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0173321
MYL12B myosin, light chain 12B, regulatory -0.0171746
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0171027
DEK DEK proto-oncogene -0.017102