Gefitinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Gefitinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0845471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0649851
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0429214
CENPF centromere protein F, 350/400kDa 0.0426548
FNIP1 folliculin interacting protein 1 0.0409741
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0390858
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0388981
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03878
LDHA lactate dehydrogenase A 0.0367358
RAB7A RAB7A, member RAS oncogene family 0.0360211
APLP2 amyloid beta (A4) precursor-like protein 2 0.0355027
SQSTM1 sequestosome 1 0.0352045
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0343543
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0341509
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0335635
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0331839
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0312655
EIF1 eukaryotic translation initiation factor 1 0.0308554
MCTP1 multiple C2 domains, transmembrane 1 0.0304268
NAV2 neuron navigator 2 0.0304241
SPAG9 sperm associated antigen 9 0.0303263
NUP58 nucleoporin 58 0.0303261
EEF2 eukaryotic translation elongation factor 2 0.0291261
MKI67 marker of proliferation Ki-67 0.0290929
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0281142
SET SET nuclear proto-oncogene 0.0277849
FTH1 ferritin, heavy polypeptide 1 0.0275096
YEATS2 YEATS domain containing 2 0.0268823
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0260747
GARS1 glycyl-tRNA synthetase 1 0.0260339
ANXA1 annexin A1 0.0257902
BRD2 bromodomain containing 2 0.0254427
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0251606
RSRC2 arginine/serine-rich coiled-coil 2 0.0247879
OGA O-GlcNAcase 0.0247745
ENO1 enolase 1, (alpha) 0.0242058
HDAC9 histone deacetylase 9 0.0240277
CXCL8 chemokine (C-X-C motif) ligand 8 0.0239292
PDIA6 protein disulfide isomerase family A, member 6 0.0238638
ESYT2 extended synaptotagmin-like protein 2 0.0230971
ANKRD11 ankyrin repeat domain 11 0.0230754
ARRDC3 arrestin domain containing 3 0.0228548
CAPRIN2 caprin family member 2 0.0226869
MSN moesin 0.0223204
TFRC transferrin receptor 0.0221959
RPS3 ribosomal protein S3 0.022171
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0220171
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0217711
OSBPL8 oxysterol binding protein-like 8 0.0217072
GLS2 glutaminase 2 (liver, mitochondrial) 0.0215128
CAMTA1 calmodulin binding transcription activator 1 0.0210521
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.021014
IARS1 isoleucyl-tRNA synthetase 1 0.0209094
CKAP5 cytoskeleton associated protein 5 0.0202256
TMED2 transmembrane emp24 domain trafficking protein 2 0.0201855
SLK STE20-like kinase 0.0201296
KLF6 Kruppel-like factor 6 0.0199722
PRELID2 PRELI domain containing 2 0.0198698
PTMA prothymosin, alpha 0.0198015
PIAS2 protein inhibitor of activated STAT, 2 0.0197678
KDM2A lysine (K)-specific demethylase 2A 0.01964
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0194848
CRY1 cryptochrome circadian clock 1 0.0194593
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.01926
HDGF hepatoma-derived growth factor 0.0191658
GIGYF2 GRB10 interacting GYF protein 2 0.0191189
MBNL2 muscleblind-like splicing regulator 2 0.0190969
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0190544
PCBP2 poly(rC) binding protein 2 0.019043
MACF1 microtubule-actin crosslinking factor 1 0.0187986
HOOK2 hook microtubule-tethering protein 2 0.0187293
MCL1 myeloid cell leukemia 1 0.0186249
SFPQ splicing factor proline/glutamine-rich 0.0185008
GOLGA4 golgin A4 0.018396
CSMD3 CUB and Sushi multiple domains 3 0.0183486
TNS3 tensin 3 0.0182642
WDR43 WD repeat domain 43 0.0182226
TM4SF1 transmembrane 4 L six family member 1 0.0181576
HSPA8 heat shock 70kDa protein 8 0.0181121
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0180576
DDIT4 DNA-damage-inducible transcript 4 0.0177376
VEGFA vascular endothelial growth factor A 0.017693
NUP98 nucleoporin 98kDa 0.0176739
DOCK11 dedicator of cytokinesis 11 0.0176552
UPP1 uridine phosphorylase 1 0.0174861
YBX1 Y box binding protein 1 0.0172041
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0171982
KDM4C lysine (K)-specific demethylase 4C 0.0171135
HILPDA hypoxia inducible lipid droplet-associated 0.0169198
RPL3 ribosomal protein L3 0.016868
DST dystonin 0.0167903
SREBF2 sterol regulatory element binding transcription factor 2 0.0167529
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0167074
EREG epiregulin 0.0165256
ZDHHC14 zinc finger, DHHC-type containing 14 0.0165015
INSIG1 insulin induced gene 1 0.0162188
CCNL1 cyclin L1 0.0160585
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0158851
NGLY1 N-glycanase 1 0.0156626
RPL21 ribosomal protein L21 0.0155039

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.106749
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0982984
PSD3 pleckstrin and Sec7 domain containing 3 -0.0959378
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0797472
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0759818
RIGI RNA sensor RIG-I -0.0728642
CD44 CD44 molecule (Indian blood group) -0.0700712
TMSB10 thymosin beta 10 -0.061148
WARS1 tryptophanyl-tRNA synthetase 1 -0.0605252
LOC112694756 uncharaterized LOC112694756 -0.0585127
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0577068
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0574815
BCAR3 breast cancer anti-estrogen resistance 3 -0.0506095
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.049136
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0480071
AHNAK AHNAK nucleoprotein -0.0470196
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0453098
TSC22D1 TSC22 domain family, member 1 -0.0431986
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0429602
HLA-B major histocompatibility complex, class I, B -0.0423109
ACTG1 actin gamma 1 -0.0399015
WWTR1 WW domain containing transcription regulator 1 -0.039604
IFIH1 interferon induced with helicase C domain 1 -0.039272
VCL vinculin -0.0386257
TXNRD1 thioredoxin reductase 1 -0.0383186
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0382806
SP100 SP100 nuclear antigen -0.037601
ZMYND8 zinc finger, MYND-type containing 8 -0.0371419
CFAP299 cilia and flagella associated protein 299 -0.0371316
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0370118
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0351832
SMYD3 SET and MYND domain containing 3 -0.0351812
RAD51B RAD51 paralog B -0.0344164
RUNX1 runt-related transcription factor 1 -0.0342971
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0341973
ADGRG6 adhesion G protein-coupled receptor G6 -0.033925
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0338946
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0336196
GCLM glutamate-cysteine ligase, modifier subunit -0.0332402
PLSCR1 phospholipid scramblase 1 -0.0323962
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0320513
RAB27B RAB27B, member RAS oncogene family -0.0311251
DPYD dihydropyrimidine dehydrogenase -0.0309078
BMERB1 bMERB domain containing 1 -0.030567
ZNFX1 zinc finger, NFX1-type containing 1 -0.0298364
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0293968
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0283746
PMP22 peripheral myelin protein 22 -0.0274793
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0273944
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0273784
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0263137
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0261225
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0254392
THSD4 thrombospondin, type I, domain containing 4 -0.0252
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0248114
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0246199
TPT1 tumor protein, translationally-controlled 1 -0.0245813
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0234363
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.023381
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0233123
RGS4 regulator of G-protein signaling 4 -0.0230619
BABAM2 BRISC and BRCA1 A complex member 2 -0.0229295
ZNF217 zinc finger protein 217 -0.0228233
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0228195
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0225996
TPM4 tropomyosin 4 -0.0225507
BCAS3 breast carcinoma amplified sequence 3 -0.0222497
HPCAL1 hippocalcin-like 1 -0.0222151
IFI6 interferon, alpha-inducible protein 6 -0.0221529
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0220974
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0220662
FBXO11 F-box protein 11 -0.0215823
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0215332
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0213551
SDCCAG8 serologically defined colon cancer antigen 8 -0.020805
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0204815
CDK6 cyclin-dependent kinase 6 -0.0203526
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0200819
AFF4 AF4/FMR2 family, member 4 -0.0200053
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0199196
FERMT1 fermitin family member 1 -0.0198388
RASAL2 RAS protein activator like 2 -0.0197923
KPNB1 karyopherin (importin) beta 1 -0.0197915
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.019379
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0191765
NPAS2 neuronal PAS domain protein 2 -0.0191688
WSB1 WD repeat and SOCS box containing 1 -0.0188431
TRIM56 tripartite motif containing 56 -0.0183268
CAPN2 calpain 2, (m/II) large subunit -0.0182797
EHBP1 EH domain binding protein 1 -0.0181455
AHNAK2 AHNAK nucleoprotein 2 -0.017955
ANKRD28 ankyrin repeat domain 28 -0.0179543
ADAR adenosine deaminase, RNA-specific -0.017923
CCDC190 coiled-coil domain containing 190 -0.0177417
SPIDR scaffolding protein involved in DNA repair -0.0177384
PYGB phosphorylase, glycogen; brain -0.0176523
VDAC1 voltage-dependent anion channel 1 -0.0175937
VEGFC vascular endothelial growth factor C -0.0175603
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0173818
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0172024