Gefitinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.103093
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0904772
FTL ferritin, light polypeptide 0.0881302
PTMA prothymosin, alpha 0.0824267
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0780778
LDHA lactate dehydrogenase A 0.0700803
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.069621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646104
ALCAM activated leukocyte cell adhesion molecule 0.0548926
POTEF POTE ankyrin domain family, member F 0.0535697
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0520767
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.050478
ANXA2 annexin A2 0.0500905
ASPH aspartate beta-hydroxylase 0.047613
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.046874
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0457904
UBC ubiquitin C 0.0405183
S100A6 S100 calcium binding protein A6 0.0393906
LMO7 LIM domain 7 0.0381526
APLP2 amyloid beta (A4) precursor-like protein 2 0.0377047
EEF2 eukaryotic translation elongation factor 2 0.0372424
ZFP36L1 ZFP36 ring finger protein-like 1 0.0361668
MYO6 myosin VI 0.0356295
TM4SF1 transmembrane 4 L six family member 1 0.0349493
CALR calreticulin 0.0343843
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.032049
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0319338
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0315331
ADAM9 ADAM metallopeptidase domain 9 0.0301278
SLC38A1 solute carrier family 38, member 1 0.0297103
MYH9 myosin, heavy chain 9, non-muscle 0.029526
ACTG1 actin gamma 1 0.0293888
CTSB cathepsin B 0.0279638
VEGFA vascular endothelial growth factor A 0.0279507
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.027451
SDC4 syndecan 4 0.0273066
EZR ezrin 0.0268301
SQSTM1 sequestosome 1 0.0266921
EIF1 eukaryotic translation initiation factor 1 0.0263004
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0262008
IGFBP3 insulin-like growth factor binding protein 3 0.0261137
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0257696
MSN moesin 0.0256595
AKAP13 A kinase (PRKA) anchor protein 13 0.0251861
RPS3 ribosomal protein S3 0.0251772
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0251245
ENO1 enolase 1, (alpha) 0.0246322
DSTN destrin (actin depolymerizing factor) 0.0243333
RPL8 ribosomal protein L8 0.0241755
DSPP dentin sialophosphoprotein 0.0240376
PRRC2C proline-rich coiled-coil 2C 0.0239926
F11R F11 receptor 0.0224045
MBNL1 muscleblind-like splicing regulator 1 0.0224039
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0222336
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0221622
CD47 CD47 molecule 0.0219887
GPBP1 GC-rich promoter binding protein 1 0.0218555
TXNIP thioredoxin interacting protein 0.0216792
BZW1 basic leucine zipper and W2 domains 1 0.0213714
CCNL1 cyclin L1 0.0212876
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0212787
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0210403
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.020839
BRD2 bromodomain containing 2 0.0206269
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205335
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0204972
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0203104
RNF145 ring finger protein 145 0.0200882
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.019526
TMSB4X thymosin beta 4, X-linked 0.0194486
TMF1 TATA element modulatory factor 1 0.0194109
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0192053
ARRDC3 arrestin domain containing 3 0.0190051
HSPA8 heat shock 70kDa protein 8 0.0187689
CD2AP CD2-associated protein 0.0186574
LAMC2 laminin, gamma 2 0.0184639
FTH1 ferritin, heavy polypeptide 1 0.0181649
KRT18 keratin 18, type I 0.0180985
EPCAM epithelial cell adhesion molecule 0.0179439
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.017896
COPA coatomer protein complex, subunit alpha 0.0178922
SETD5 SET domain containing 5 0.0177156
DSCAM Down syndrome cell adhesion molecule 0.0176147
PGK1 phosphoglycerate kinase 1 0.0175881
CALU calumenin 0.0175235
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0173408
RSRC2 arginine/serine-rich coiled-coil 2 0.0173147
HMGB2 high mobility group box 2 0.0172872
TMED2 transmembrane emp24 domain trafficking protein 2 0.0172845
G0S2 G0/G1 switch 2 0.0170225
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0170017
SH3KBP1 SH3-domain kinase binding protein 1 0.0168164
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0167653
RACK1 receptor for activated C kinase 1 0.01674
TPM3 tropomyosin 3 0.0165702
KRT7 keratin 7, type II 0.016315
GOLGA4 golgin A4 0.0160058
BHLHE40 basic helix-loop-helix family, member e40 0.0156838
TMEM263 transmembrane protein 263 0.0156135
DSG2 desmoglein 2 0.0155693

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0185253
RPL35A ribosomal protein L35a -0.0171526
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0146033
WSB1 WD repeat and SOCS box containing 1 -0.0132815
FBXO34 F-box protein 34 -0.0126529
OSBPL3 oxysterol binding protein-like 3 -0.00993146
RPL9 ribosomal protein L9 -0.00936226
DTNA dystrobrevin, alpha -0.00923257
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0086216
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00805903
F3 coagulation factor III (thromboplastin, tissue factor) -0.00803136
RAD51B RAD51 paralog B -0.00755408
FAM3C family with sequence similarity 3, member C -0.00704937
LOC112694756 uncharaterized LOC112694756 -0.00693538
JARID2 jumonji, AT rich interactive domain 2 -0.00693511
VCL vinculin -0.00689366
NAV2 neuron navigator 2 -0.00689159
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0067783
KIAA1217 KIAA1217 -0.0067079
FHIT fragile histidine triad -0.00661286
CDCP1 CUB domain containing protein 1 -0.00657221
NDRG1 N-myc downstream regulated 1 -0.00657027
GRB10 growth factor receptor-bound protein 10 -0.00646245
RPL30 ribosomal protein L30 -0.00644001
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.00619897
AHNAK AHNAK nucleoprotein -0.00618884
SNRK SNF related kinase -0.00609025
NUMB numb homolog (Drosophila) -0.00591526
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.00586118
FLNA filamin A, alpha -0.00566314
CAB39 calcium binding protein 39 -0.00564829
PALLD palladin, cytoskeletal associated protein -0.00535629
METTL15 methyltransferase like 15 -0.00531376
TMEM51 transmembrane protein 51 -0.00530661
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00528759
DENND2C DENN/MADD domain containing 2C -0.00496145
SYT1 synaptotagmin I -0.00493417
IFIH1 interferon induced with helicase C domain 1 -0.00488312
LOXL2 lysyl oxidase-like 2 -0.00486605
EFNA5 ephrin-A5 -0.00481083
SMAD3 SMAD family member 3 -0.00480473
RPS24 ribosomal protein S24 -0.00464146
TENT4A terminal nucleotidyltransferase 4A -0.00463171
PML promyelocytic leukemia -0.00462792
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00462507
AFF4 AF4/FMR2 family, member 4 -0.00462401
FBXO33 F-box protein 33 -0.0046139
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00461183
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.00458202
IREB2 iron-responsive element binding protein 2 -0.00457167
RIGI RNA sensor RIG-I -0.00455265
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.00447066
KCMF1 potassium channel modulatory factor 1 -0.00446713
ZFR zinc finger RNA binding protein -0.00446466
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -0.00441537
DLG1 discs, large homolog 1 (Drosophila) -0.0043852
DCAF6 DDB1 and CUL4 associated factor 6 -0.00430582
COL1A1 collagen, type I, alpha 1 -0.00424993
TUBB4B tubulin, beta 4B class IVb -0.00424084
FBXO32 F-box protein 32 -0.00423864
COL6A2 collagen, type VI, alpha 2 -0.00420276
NDFIP1 Nedd4 family interacting protein 1 -0.00413747
NRIP1 nuclear receptor interacting protein 1 -0.00412989
BRWD3 bromodomain and WD repeat domain containing 3 -0.00401717
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.00395801
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0039184
ZNF267 zinc finger protein 267 -0.00385817
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00381202
TMEM165 transmembrane protein 165 -0.00379803
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.00379281
JUP junction plakoglobin -0.00377924
ZC3H15 zinc finger CCCH-type containing 15 -0.0037448
RPL27 ribosomal protein L27 -0.00373784
KDM7A lysine (K)-specific demethylase 7A -0.00372884
PELI1 pellino E3 ubiquitin protein ligase 1 -0.00371982
HPCAL1 hippocalcin-like 1 -0.00371009
PRMT2 protein arginine methyltransferase 2 -0.00369826
ZFAND6 zinc finger, AN1-type domain 6 -0.0036927
RARS1 arginyl-tRNA synthetase 1 -0.00368893
ZNF592 zinc finger protein 592 -0.00368836
PMP22 peripheral myelin protein 22 -0.00367755
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -0.00365048
CYTH1 cytohesin 1 -0.00361037
PCNP PEST proteolytic signal containing nuclear protein -0.00360359
NT5C2 5'-nucleotidase, cytosolic II -0.00358653
LRMDA leucine rich melanocyte differentiation associated -0.00357789
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.00349598
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.00349274
GPR180 G protein-coupled receptor 180 -0.00347494
ZNF33A zinc finger protein 33A -0.00345983
TUBB6 tubulin, beta 6 class V -0.00344898
ZNFX1 zinc finger, NFX1-type containing 1 -0.00342324
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.00340552
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0034044
MDM4 MDM4, p53 regulator -0.00339445
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.00337697
ZNF251 zinc finger protein 251 -0.00330625
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.00328592
GPC6 glypican 6 -0.00328588
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0032496