Gefitinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.172287
AKAP12 A kinase (PRKA) anchor protein 12 0.155163
DSCAM Down syndrome cell adhesion molecule 0.137138
NDRG1 N-myc downstream regulated 1 0.113477
ENO1 enolase 1, (alpha) 0.111143
ARHGAP5 Rho GTPase activating protein 5 0.103341
VIM vimentin 0.10221
PTMA prothymosin, alpha 0.0992941
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0930704
RPS3 ribosomal protein S3 0.0859462
SPAG9 sperm associated antigen 9 0.0823505
JMJD1C jumonji domain containing 1C 0.0809967
SPTBN1 spectrin, beta, non-erythrocytic 1 0.080556
PTK2 protein tyrosine kinase 2 0.0792495
ANXA2 annexin A2 0.0783753
UBA6 ubiquitin-like modifier activating enzyme 6 0.0774846
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0759199
LOC102724023 ES1 protein homolog, mitochondrial 0.0757548
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0744958
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0744881
KMT2E lysine (K)-specific methyltransferase 2E 0.0740442
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0740337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0733216
RPS8 ribosomal protein S8 0.0725464
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0717154
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0712318
ITGA6 integrin, alpha 6 0.0708466
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0706557
RUNX1 runt-related transcription factor 1 0.0700157
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0698679
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0693568
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0690549
MYO1E myosin IE 0.0674854
SOS1 son of sevenless homolog 1 (Drosophila) 0.0674526
KMT2C lysine (K)-specific methyltransferase 2C 0.0671131
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0662854
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0647768
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0621072
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0620728
UBAP2L ubiquitin associated protein 2-like 0.0605269
SQSTM1 sequestosome 1 0.0602386
LDHA lactate dehydrogenase A 0.0596844
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0578904
PRRC2C proline-rich coiled-coil 2C 0.0564106
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0563419
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0561368
RACK1 receptor for activated C kinase 1 0.0557004
H1-0 H1.0 linker histone 0.0554969
SMAD3 SMAD family member 3 0.0543901
CERT1 ceramide transporter 1 0.05349
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.053456
PUM1 pumilio RNA-binding family member 1 0.0531261
PGK1 phosphoglycerate kinase 1 0.0529732
CLASP1 cytoplasmic linker associated protein 1 0.0527065
RAB7A RAB7A, member RAS oncogene family 0.0524554
EEF2 eukaryotic translation elongation factor 2 0.05146
FLNB filamin B, beta 0.05145
MEF2A myocyte enhancer factor 2A 0.0509313
RSRC2 arginine/serine-rich coiled-coil 2 0.0500302
SNX9 sorting nexin 9 0.0499972
COL6A3 collagen, type VI, alpha 3 0.0494227
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0487479
PRELID2 PRELI domain containing 2 0.0480072
MACF1 microtubule-actin crosslinking factor 1 0.0479893
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0478183
RBM39 RNA binding motif protein 39 0.0476294
RPL26 ribosomal protein L26 0.0468233
USP34 ubiquitin specific peptidase 34 0.0459073
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0454752
RPS16 ribosomal protein S16 0.044812
CDH13 cadherin 13 0.043695
TRIO trio Rho guanine nucleotide exchange factor 0.0433136
MEST mesoderm specific transcript 0.0425861
RPL12 ribosomal protein L12 0.0418888
VMP1 vacuole membrane protein 1 0.0414505
ZFC3H1 zinc finger, C3H1-type containing 0.041398
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0409703
FMNL2 formin-like 2 0.0408599
TMSB10 thymosin beta 10 0.0407678
WDR45B WD repeat domain 45B 0.0405054
LIMCH1 LIM and calponin homology domains 1 0.0400308
ZNF292 zinc finger protein 292 0.0399021
RPS12 ribosomal protein S12 0.0397766
LCORL ligand dependent nuclear receptor corepressor-like 0.0397702
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0395942
ANO6 anoctamin 6 0.0393236
HILPDA hypoxia inducible lipid droplet-associated 0.038306
RPS6 ribosomal protein S6 0.0375782
AKAP9 A kinase (PRKA) anchor protein 9 0.0375709
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0368266
NIPBL Nipped-B homolog (Drosophila) 0.0367695
TTC3 tetratricopeptide repeat domain 3 0.0350837
ACTN4 actinin, alpha 4 0.0350448
RPL11 ribosomal protein L11 0.0346746
EPS8 epidermal growth factor receptor pathway substrate 8 0.034625
LPP LIM domain containing preferred translocation partner in lipoma 0.0335242
TP53BP2 tumor protein p53 binding protein 2 0.0331169
ATXN1 ataxin 1 0.0330275
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.032941
YAP1 Yes-associated protein 1 0.0326482

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.132917
ELL2 elongation factor, RNA polymerase II, 2 -0.126459
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.109589
NCOR1 nuclear receptor corepressor 1 -0.105111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102846
ZNF608 zinc finger protein 608 -0.0999195
FNDC3A fibronectin type III domain containing 3A -0.0994572
NAMPT nicotinamide phosphoribosyltransferase -0.0983941
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0980521
PEG10 paternally expressed 10 -0.0929998
FGFR2 fibroblast growth factor receptor 2 -0.0916007
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0904648
EXT1 exostosin glycosyltransferase 1 -0.084232
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0814971
RYBP RING1 and YY1 binding protein -0.076639
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0757662
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0729136
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0728985
HELZ helicase with zinc finger -0.0719415
WSB1 WD repeat and SOCS box containing 1 -0.071224
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0705201
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0704056
MARCHF6 membrane associated ring-CH-type finger 6 -0.0699848
CAMTA1 calmodulin binding transcription activator 1 -0.0684701
MED13 mediator complex subunit 13 -0.0683768
HDLBP high density lipoprotein binding protein -0.0677572
ZBTB20 zinc finger and BTB domain containing 20 -0.0624792
PDE8A phosphodiesterase 8A -0.0615443
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.060156
RPL23 ribosomal protein L23 -0.0593066
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0589377
MTDH metadherin -0.0578353
HMGA2 high mobility group AT-hook 2 -0.0569782
EGFR epidermal growth factor receptor -0.0563984
ZFHX3 zinc finger homeobox 3 -0.0561053
CHD9 chromodomain helicase DNA binding protein 9 -0.0554909
GOLGB1 golgin B1 -0.055371
TPT1 tumor protein, translationally-controlled 1 -0.0551563
CNKSR3 CNKSR family member 3 -0.0541259
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0533029
CD46 CD46 molecule, complement regulatory protein -0.0527608
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0523145
MON2 MON2 homolog (S. cerevisiae) -0.0520264
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0510924
PRPF38B pre-mRNA processing factor 38B -0.0507156
UBE2H ubiquitin-conjugating enzyme E2H -0.0502679
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0494866
CADM2 cell adhesion molecule 2 -0.049333
TPR translocated promoter region, nuclear basket protein -0.0492581
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0473928
ACTG1 actin gamma 1 -0.047152
ASXL1 additional sex combs like transcriptional regulator 1 -0.047012
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0467466
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0455311
KDM4C lysine (K)-specific demethylase 4C -0.0452988
EXOC4 exocyst complex component 4 -0.0450994
FAM13A family with sequence similarity 13, member A -0.044677
GNAS GNAS complex locus -0.0443049
GSK3B glycogen synthase kinase 3 beta -0.0441825
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0441502
ZNF217 zinc finger protein 217 -0.0436011
PRKG1 protein kinase, cGMP-dependent, type I -0.0435136
NAV2 neuron navigator 2 -0.0432987
AFF4 AF4/FMR2 family, member 4 -0.042957
LMAN1 lectin, mannose-binding, 1 -0.0429117
RIGI RNA sensor RIG-I -0.0424074
PDLIM5 PDZ and LIM domain 5 -0.0419936
RNF213 ring finger protein 213 -0.0415125
DST dystonin -0.0414824
RPL8 ribosomal protein L8 -0.041314
OGA O-GlcNAcase -0.0408039
KMT2A lysine (K)-specific methyltransferase 2A -0.0404746
NKD1 naked cuticle homolog 1 (Drosophila) -0.0403628
CCNI cyclin I -0.0402991
RBM25 RNA binding motif protein 25 -0.0396022
AFDN afadin, adherens junction formation factor -0.0394787
PRKCA protein kinase C, alpha -0.03936
EPB41 erythrocyte membrane protein band 4.1 -0.0391903
RAD51B RAD51 paralog B -0.0385892
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.038285
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0362301
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0360857
ANKRD17 ankyrin repeat domain 17 -0.0353232
UGCG UDP-glucose ceramide glucosyltransferase -0.0340339
CD44 CD44 molecule (Indian blood group) -0.0338978
OSBPL8 oxysterol binding protein-like 8 -0.0338848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0334708
NSD3 nuclear receptor binding SET domain protein 3 -0.0334429
MT2A metallothionein 2A -0.0332966
NPAS2 neuronal PAS domain protein 2 -0.0332386
SEC31A SEC31 homolog A (S. cerevisiae) -0.033068
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0330335
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0327404
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0326018
PCBP2 poly(rC) binding protein 2 -0.0325149
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0325083
MAML2 mastermind-like 2 (Drosophila) -0.0321322
CAMKMT calmodulin-lysine N-methyltransferase -0.0316675
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.031393
BIRC6 baculoviral IAP repeat containing 6 -0.0311141