Gefitinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.11719
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.091755
ZNF292 zinc finger protein 292 0.0850241
GOLGA4 golgin A4 0.0779362
NAMPT nicotinamide phosphoribosyltransferase 0.0707643
SSBP2 single-stranded DNA binding protein 2 0.0696447
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0691656
EIF4A2 eukaryotic translation initiation factor 4A2 0.0689248
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0682069
TXNIP thioredoxin interacting protein 0.0590685
KDM3A lysine (K)-specific demethylase 3A 0.0566624
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0562924
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0558732
LDHA lactate dehydrogenase A 0.0544834
RBM39 RNA binding motif protein 39 0.0543602
NUP58 nucleoporin 58 0.0518087
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0511661
RNF145 ring finger protein 145 0.0511038
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0503168
QKI QKI, KH domain containing, RNA binding 0.0501657
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0490596
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0471937
CDC73 cell division cycle 73 0.0466116
KMT2E lysine (K)-specific methyltransferase 2E 0.0462496
CCNL1 cyclin L1 0.0453252
ADAM10 ADAM metallopeptidase domain 10 0.0446803
MATR3 matrin 3 0.0445306
NCKAP1 NCK-associated protein 1 0.0445296
EEF2 eukaryotic translation elongation factor 2 0.0444121
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.041165
GARS1 glycyl-tRNA synthetase 1 0.040457
USP3 ubiquitin specific peptidase 3 0.0392775
ADAM9 ADAM metallopeptidase domain 9 0.038931
HDAC9 histone deacetylase 9 0.0388737
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0379338
EZR ezrin 0.037349
HELZ helicase with zinc finger 0.0367113
FLNB filamin B, beta 0.0359649
ECT2 epithelial cell transforming 2 0.0353246
TFG TRK-fused gene 0.0351831
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0350671
ZMYM2 zinc finger, MYM-type 2 0.0346291
CD47 CD47 molecule 0.0346231
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330856
UBA6 ubiquitin-like modifier activating enzyme 6 0.0325922
PGK1 phosphoglycerate kinase 1 0.0325663
BRWD1 bromodomain and WD repeat domain containing 1 0.0320588
TMSB4X thymosin beta 4, X-linked 0.0317924
PTBP2 polypyrimidine tract binding protein 2 0.0317444
ZEB1 zinc finger E-box binding homeobox 1 0.0314776
PNISR PNN-interacting serine/arginine-rich protein 0.031311
RSRC2 arginine/serine-rich coiled-coil 2 0.0312625
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.029613
NBAS neuroblastoma amplified sequence 0.0295176
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0294623
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0294411
FXR1 fragile X mental retardation, autosomal homolog 1 0.0294045
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0293812
PRRC2C proline-rich coiled-coil 2C 0.029247
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0292111
TXNRD1 thioredoxin reductase 1 0.0292052
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0287083
CASC3 cancer susceptibility candidate 3 0.0285541
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0280997
EML4 echinoderm microtubule associated protein like 4 0.0277806
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0273873
XPO1 exportin 1 0.0271831
WAC WW domain containing adaptor with coiled-coil 0.0269705
TTC3 tetratricopeptide repeat domain 3 0.0269181
RAB6A RAB6A, member RAS oncogene family 0.0268711
PDIA6 protein disulfide isomerase family A, member 6 0.0268455
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0266427
B2M beta-2-microglobulin 0.0264317
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0259536
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0259491
BCLAF1 BCL2-associated transcription factor 1 0.0256546
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254853
TRA2A transformer 2 alpha homolog (Drosophila) 0.0254435
EVI5 ecotropic viral integration site 5 0.0251057
ELOVL5 ELOVL fatty acid elongase 5 0.0250423
PDIA3 protein disulfide isomerase family A, member 3 0.0249301
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0248361
MEF2A myocyte enhancer factor 2A 0.0247653
FOXJ3 forkhead box J3 0.0247453
KDM6A lysine (K)-specific demethylase 6A 0.0245436
GSK3B glycogen synthase kinase 3 beta 0.0244895
SPRED2 sprouty-related, EVH1 domain containing 2 0.0244179
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0242925
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0241656
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0241165
ZFAND3 zinc finger, AN1-type domain 3 0.0239559
NCOR1 nuclear receptor corepressor 1 0.0239357
BIRC6 baculoviral IAP repeat containing 6 0.0236391
ANK2 ankyrin 2, neuronal 0.0233758
PTK2 protein tyrosine kinase 2 0.0233192
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0232903
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0230554
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0230542
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0229508
ECPAS Ecm29 proteasome adaptor and scaffold 0.0229263

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.102961
PTMA prothymosin, alpha -0.095985
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0911559
RPL35A ribosomal protein L35a -0.0730218
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0718299
RPL31 ribosomal protein L31 -0.0690823
RPS6 ribosomal protein S6 -0.0648456
BMP10 bone morphogenetic protein 10 -0.063067
PDE4D phosphodiesterase 4D, cAMP-specific -0.0620871
RPLP1 ribosomal protein, large, P1 -0.0541805
RPS23 ribosomal protein S23 -0.0509622
RPS13 ribosomal protein S13 -0.0506916
RPL9 ribosomal protein L9 -0.0502132
RPL34 ribosomal protein L34 -0.0501733
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0491166
VCL vinculin -0.0481053
RPS8 ribosomal protein S8 -0.0460859
FOXP1 forkhead box P1 -0.0455228
CCND1 cyclin D1 -0.0454855
RPS25 ribosomal protein S25 -0.044165
RPL37A ribosomal protein L37a -0.0407923
RPLP2 ribosomal protein, large, P2 -0.036237
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0361279
TUBB4B tubulin, beta 4B class IVb -0.0346651
PDE4B phosphodiesterase 4B, cAMP-specific -0.0341298
RPS24 ribosomal protein S24 -0.0335648
ACTG1 actin gamma 1 -0.0334164
RPL26 ribosomal protein L26 -0.0330784
RPS3 ribosomal protein S3 -0.0318085
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0314076
RPS27A ribosomal protein S27a -0.0300549
RPS29 ribosomal protein S29 -0.0299792
RPL38 ribosomal protein L38 -0.0296039
RPL30 ribosomal protein L30 -0.0278897
RPL19 ribosomal protein L19 -0.027733
RPS21 ribosomal protein S21 -0.0277046
ZMYND8 zinc finger, MYND-type containing 8 -0.0266706
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264361
RPL23 ribosomal protein L23 -0.0263866
RFC3 replication factor C (activator 1) 3, 38kDa -0.0263172
MYL12B myosin, light chain 12B, regulatory -0.0261564
SMC4 structural maintenance of chromosomes 4 -0.0257849
EGFR epidermal growth factor receptor -0.0257308
NBEA neurobeachin -0.0253777
SLC38A2 solute carrier family 38, member 2 -0.0252659
RPL7A ribosomal protein L7a -0.0251868
RPS19 ribosomal protein S19 -0.0244728
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0244279
ENO2 enolase 2 (gamma, neuronal) -0.0242371
RPS16 ribosomal protein S16 -0.0237735
RPS12 ribosomal protein S12 -0.0235648
TAS2R14 taste receptor, type 2, member 14 -0.0235636
INTS6 integrator complex subunit 6 -0.0235279
RPL37 ribosomal protein L37 -0.0234497
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.023173
MKI67 marker of proliferation Ki-67 -0.0225681
TUBA1B tubulin, alpha 1b -0.0225189
SEPTIN9 septin 9 -0.0224479
RPL11 ribosomal protein L11 -0.0223969
ANKRD17 ankyrin repeat domain 17 -0.0223315
NOP56 NOP56 ribonucleoprotein -0.0220518
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0220035
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0215433
RPL27A ribosomal protein L27a -0.0214404
TM4SF1 transmembrane 4 L six family member 1 -0.0214164
AEBP2 AE binding protein 2 -0.0213257
PDE7B phosphodiesterase 7B -0.021264
RPL15 ribosomal protein L15 -0.0212112
RPL36A ribosomal protein L36a -0.0211561
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0208108
S100A9 S100 calcium binding protein A9 -0.0207295
KPNB1 karyopherin (importin) beta 1 -0.0203782
GSE1 Gse1 coiled-coil protein -0.0202427
LOC102724023 ES1 protein homolog, mitochondrial -0.0202224
CENPF centromere protein F, 350/400kDa -0.0201544
DIAPH3 diaphanous-related formin 3 -0.020144
TBCA tubulin folding cofactor A -0.0200907
ASPH aspartate beta-hydroxylase -0.0199446
ITGA10 integrin, alpha 10 -0.019856
RRM2 ribonucleotide reductase M2 -0.0195144
RPS27 ribosomal protein S27 -0.0195035
NFE2L2 nuclear factor, erythroid 2-like 2 -0.019501
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0194144
PSD3 pleckstrin and Sec7 domain containing 3 -0.0193158
PCNX4 pecanex 4 -0.0192287
BCOR BCL6 corepressor -0.0185549
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0182298
GPATCH8 G patch domain containing 8 -0.0181202
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0180933
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0179031
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0178848
S100A10 S100 calcium binding protein A10 -0.0178463
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.017717
HSPB1 heat shock 27kDa protein 1 -0.0172749
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0171839
CUX1 cut-like homeobox 1 -0.0168719
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.016778
HMGB1 high mobility group box 1 -0.0166266
RPS5 ribosomal protein S5 -0.0165961
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0165423