Gefitinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gefitinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gefitinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.127014
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.098055
MYH9 myosin, heavy chain 9, non-muscle 0.0878746
OGA O-GlcNAcase 0.0811882
EEF2 eukaryotic translation elongation factor 2 0.0719677
FN1 fibronectin 1 0.0647104
NAV2 neuron navigator 2 0.0618246
ARRDC3 arrestin domain containing 3 0.0608912
ANLN anillin, actin binding protein 0.0595543
UGCG UDP-glucose ceramide glucosyltransferase 0.0592095
USP9X ubiquitin specific peptidase 9, X-linked 0.054783
TENT5A terminal nucleotidyltransferase 5A 0.0546142
AFDN afadin, adherens junction formation factor 0.0497459
CENPF centromere protein F, 350/400kDa 0.0488486
RB1CC1 RB1-inducible coiled-coil 1 0.0486528
MSN moesin 0.0475098
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0462183
SDC4 syndecan 4 0.0456035
MKI67 marker of proliferation Ki-67 0.044052
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0429743
MXI1 MAX interactor 1, dimerization protein 0.0429353
CDK19 cyclin-dependent kinase 19 0.042598
UBA6 ubiquitin-like modifier activating enzyme 6 0.0419292
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0416948
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0416387
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0405035
FLNB filamin B, beta 0.0390771
ATP13A3 ATPase type 13A3 0.0381632
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0372434
CKAP5 cytoskeleton associated protein 5 0.0368932
APP amyloid beta (A4) precursor protein 0.0361551
ELL2 elongation factor, RNA polymerase II, 2 0.0356354
KIF4A kinesin family member 4A 0.0351813
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0343476
PRELID2 PRELI domain containing 2 0.033852
FNIP1 folliculin interacting protein 1 0.0335143
RBM39 RNA binding motif protein 39 0.0333151
DIAPH3 diaphanous-related formin 3 0.0327226
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0324229
NAMPT nicotinamide phosphoribosyltransferase 0.0322487
ESYT2 extended synaptotagmin-like protein 2 0.0322411
SPAG9 sperm associated antigen 9 0.031894
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0318923
PDE10A phosphodiesterase 10A 0.0318045
ECPAS Ecm29 proteasome adaptor and scaffold 0.0314978
FMNL2 formin-like 2 0.0314019
RICTOR RPTOR independent companion of MTOR, complex 2 0.0308717
GSK3B glycogen synthase kinase 3 beta 0.0302103
JMJD1C jumonji domain containing 1C 0.0302005
OSBPL8 oxysterol binding protein-like 8 0.0290632
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0287512
PPARD peroxisome proliferator-activated receptor delta 0.0287213
OPTN optineurin 0.0282618
KIF13A kinesin family member 13A 0.0281995
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0276356
YEATS2 YEATS domain containing 2 0.0275073
IL1RAP interleukin 1 receptor accessory protein 0.0270954
LPP LIM domain containing preferred translocation partner in lipoma 0.0270647
RLIM ring finger protein, LIM domain interacting 0.0267431
DST dystonin 0.0267337
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0265256
PCBP2 poly(rC) binding protein 2 0.0263378
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.026265
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0260858
TTK TTK protein kinase 0.0260336
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259959
MBNL1 muscleblind-like splicing regulator 1 0.0259021
PICALM phosphatidylinositol binding clathrin assembly protein 0.0258442
KLF6 Kruppel-like factor 6 0.0258301
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0247218
PTBP3 polypyrimidine tract binding protein 3 0.0246415
NF1 neurofibromin 1 0.0242224
ZNF292 zinc finger protein 292 0.0241885
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0241694
NONO non-POU domain containing, octamer-binding 0.0241216
SERINC1 serine incorporator 1 0.0240931
GAS2L3 growth arrest-specific 2 like 3 0.0240706
ABTB3 ankyrin repeat and BTB domain containing 3 0.023929
HELZ helicase with zinc finger 0.0237772
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.023726
SBF2 SET binding factor 2 0.0235885
IGF2R insulin-like growth factor 2 receptor 0.0235418
LAMP2 lysosomal-associated membrane protein 2 0.0231783
NCOA3 nuclear receptor coactivator 3 0.0229459
TPX2 TPX2, microtubule-associated 0.0228188
BBX bobby sox homolog (Drosophila) 0.0227645
NCKAP1 NCK-associated protein 1 0.0225216
PHIP pleckstrin homology domain interacting protein 0.022467
SMC4 structural maintenance of chromosomes 4 0.022204
DSCAM Down syndrome cell adhesion molecule 0.0221354
MIS18BP1 MIS18 binding protein 1 0.0219428
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0218237
AKAP13 A kinase (PRKA) anchor protein 13 0.0215923
CSDE1 cold shock domain containing E1, RNA-binding 0.021553
ADM adrenomedullin 0.0215202
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0214353
NT5C2 5'-nucleotidase, cytosolic II 0.0213998
TRAM2 translocation associated membrane protein 2 0.0212084
EIF4B eukaryotic translation initiation factor 4B 0.0210458
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0209779

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.178231
HLA-B major histocompatibility complex, class I, B -0.148003
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126098
TMSB10 thymosin beta 10 -0.123887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123449
FTL ferritin, light polypeptide -0.117285
IER3 immediate early response 3 -0.110161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0848314
RPS6 ribosomal protein S6 -0.0814055
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0774648
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0728632
FRMD4A FERM domain containing 4A -0.067456
CALR calreticulin -0.0643162
RPL35A ribosomal protein L35a -0.0639636
RPS8 ribosomal protein S8 -0.0636522
TPT1 tumor protein, translationally-controlled 1 -0.0591426
VCL vinculin -0.0587907
RPL23 ribosomal protein L23 -0.0574089
RPL37A ribosomal protein L37a -0.057067
RPS12 ribosomal protein S12 -0.0560978
MT2A metallothionein 2A -0.0539079
HLA-A major histocompatibility complex, class I, A -0.0508487
RPLP2 ribosomal protein, large, P2 -0.0483583
RPLP1 ribosomal protein, large, P1 -0.0480885
HMGA2 high mobility group AT-hook 2 -0.0472512
RPL9 ribosomal protein L9 -0.0469806
IFITM3 interferon induced transmembrane protein 3 -0.0450793
IGFBP3 insulin-like growth factor binding protein 3 -0.0444666
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0435189
GLIS3 GLIS family zinc finger 3 -0.0426236
CDH13 cadherin 13 -0.0420836
B2M beta-2-microglobulin -0.042051
ENO1 enolase 1, (alpha) -0.0419336
TGFBI transforming growth factor, beta-induced, 68kDa -0.0414877
RPS24 ribosomal protein S24 -0.0412615
S100A9 S100 calcium binding protein A9 -0.0394348
EGFR epidermal growth factor receptor -0.0387342
RPS3 ribosomal protein S3 -0.0387124
FTH1 ferritin, heavy polypeptide 1 -0.0387009
TPM4 tropomyosin 4 -0.0385276
IFI6 interferon, alpha-inducible protein 6 -0.0383792
CTSD cathepsin D -0.0383586
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0381705
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0379449
RPS25 ribosomal protein S25 -0.0376957
RPS19 ribosomal protein S19 -0.0373726
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.037019
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0366816
RPL12 ribosomal protein L12 -0.0358532
RPS23 ribosomal protein S23 -0.0351149
WSB1 WD repeat and SOCS box containing 1 -0.033806
RPL36 ribosomal protein L36 -0.0337953
SQSTM1 sequestosome 1 -0.0337846
RPL31 ribosomal protein L31 -0.0335686
RPL36A ribosomal protein L36a -0.0330502
RPS10 ribosomal protein S10 -0.032897
RPL5 ribosomal protein L5 -0.0307607
ISG15 ISG15 ubiquitin-like modifier -0.0302497
RIGI RNA sensor RIG-I -0.0302273
C3 complement component 3 -0.0301062
ZHX2 zinc fingers and homeoboxes 2 -0.0299722
RPL39 ribosomal protein L39 -0.0299471
RPS14 ribosomal protein S14 -0.0299162
RPL35 ribosomal protein L35 -0.0297568
RPS13 ribosomal protein S13 -0.029222
IFITM1 interferon induced transmembrane protein 1 -0.0290998
COL5A1 collagen, type V, alpha 1 -0.0289463
NAV1 neuron navigator 1 -0.0287627
RPL19 ribosomal protein L19 -0.0276638
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0272186
PGK1 phosphoglycerate kinase 1 -0.0271848
RACK1 receptor for activated C kinase 1 -0.0271637
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0271313
DIAPH2 diaphanous-related formin 2 -0.0269029
GNAS GNAS complex locus -0.02686
PTPRK protein tyrosine phosphatase, receptor type, K -0.0265456
TPM1 tropomyosin 1 (alpha) -0.0261691
ENO2 enolase 2 (gamma, neuronal) -0.0259892
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0259417
INTS6 integrator complex subunit 6 -0.0258972
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0256482
LOC112694756 uncharaterized LOC112694756 -0.0253752
RPS20 ribosomal protein S20 -0.0252558
RPS21 ribosomal protein S21 -0.0246358
EXT1 exostosin glycosyltransferase 1 -0.0245743
IL6 interleukin 6 -0.0244411
KYNU kynureninase -0.0243554
RPL37 ribosomal protein L37 -0.0242454
CD44 CD44 molecule (Indian blood group) -0.0241091
RPL32 ribosomal protein L32 -0.0238281
IGFBP7 insulin-like growth factor binding protein 7 -0.0237678
WTAP Wilms tumor 1 associated protein -0.0236861
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0235113
RPS17 ribosomal protein S17 -0.0234346
PMP22 peripheral myelin protein 22 -0.02333
RPL28 ribosomal protein L28 -0.0233296
SLC38A1 solute carrier family 38, member 1 -0.0230823
RPL26 ribosomal protein L26 -0.0229039
SFRP1 secreted frizzled-related protein 1 -0.0227149
RPS27 ribosomal protein S27 -0.0227039