| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Gemcitabine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Gemcitabine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.25204 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.135003 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.128424 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.127194 |
| C3 | complement component 3 | 0.117209 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.114134 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.11378 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.110363 |
| ENO1 | enolase 1, (alpha) | 0.10724 |
| SVIL | supervillin | 0.104162 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.101976 |
| TXNRD1 | thioredoxin reductase 1 | 0.100842 |
| FAM107B | family with sequence similarity 107, member B | 0.0952666 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0908897 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0896041 |
| DSPP | dentin sialophosphoprotein | 0.0797007 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0756967 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0630959 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0624955 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0587412 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0585278 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0563508 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0543292 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0522349 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.05205 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0517307 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0516429 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0499942 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0498045 |
| RPL3 | ribosomal protein L3 | 0.0497383 |
| SIK3 | SIK family kinase 3 | 0.0487743 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0487684 |
| MYO1B | myosin IB | 0.0475993 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0462318 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0450509 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0442418 |
| LDHA | lactate dehydrogenase A | 0.0438453 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0438407 |
| CRY1 | cryptochrome circadian clock 1 | 0.043509 |
| AHSG | alpha-2-HS-glycoprotein | 0.043445 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0433552 |
| ASPH | aspartate beta-hydroxylase | 0.0430558 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0421926 |
| KYNU | kynureninase | 0.041941 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0413007 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0402444 |
| LMO7 | LIM domain 7 | 0.0395484 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0390075 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0386653 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.038554 |
| AFDN | afadin, adherens junction formation factor | 0.0381565 |
| CLIC4 | chloride intracellular channel 4 | 0.0377167 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0376214 |
| RAB10 | RAB10, member RAS oncogene family | 0.0372403 |
| KIF1B | kinesin family member 1B | 0.0356602 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0352288 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0349957 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.034783 |
| DSTN | destrin (actin depolymerizing factor) | 0.0347379 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0345312 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.034504 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.0344892 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0341762 |
| NUP58 | nucleoporin 58 | 0.0340204 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0336516 |
| SDC4 | syndecan 4 | 0.0335742 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0334141 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0333612 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0333461 |
| QKI | QKI, KH domain containing, RNA binding | 0.0330317 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0328778 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0326014 |
| CD109 | CD109 molecule | 0.0323708 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.03223 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0322136 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0321436 |
| PAPOLA | poly(A) polymerase alpha | 0.0320433 |
| TF | transferrin | 0.0319986 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0316351 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0314826 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0314345 |
| RPL4 | ribosomal protein L4 | 0.0309851 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.030801 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0306285 |
| USP47 | ubiquitin specific peptidase 47 | 0.0304277 |
| PKM | pyruvate kinase, muscle | 0.0302659 |
| JAK1 | Janus kinase 1 | 0.030153 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0293029 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0290653 |
| OPTN | optineurin | 0.0290094 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0289764 |
| HSPA8 | heat shock 70kDa protein 8 | 0.02896 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0289415 |
| FAT1 | FAT atypical cadherin 1 | 0.0287053 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0283684 |
| RPS25 | ribosomal protein S25 | 0.0282832 |
| TLE4 | transducin-like enhancer of split 4 | 0.0282024 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0276645 |
| CPE | carboxypeptidase E | 0.0274784 |
| USP34 | ubiquitin specific peptidase 34 | 0.0273938 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.0931708 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0914456 |
| IGF2 | insulin-like growth factor 2 | -0.0836874 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0826414 |
| EHBP1 | EH domain binding protein 1 | -0.078484 |
| APOB | apolipoprotein B | -0.0767203 |
| CP | ceruloplasmin (ferroxidase) | -0.0761052 |
| TMSB10 | thymosin beta 10 | -0.0751673 |
| FN1 | fibronectin 1 | -0.0734953 |
| GPC6 | glypican 6 | -0.0734842 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0682725 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0633886 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0630847 |
| RRBP1 | ribosome binding protein 1 | -0.0630127 |
| APOA2 | apolipoprotein A-II | -0.0603413 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0600876 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0597759 |
| MT2A | metallothionein 2A | -0.0589228 |
| GNAS | GNAS complex locus | -0.0572875 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0566685 |
| VCL | vinculin | -0.0564713 |
| GPC3 | glypican 3 | -0.0554932 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0538362 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0534592 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0514377 |
| RPLP1 | ribosomal protein, large, P1 | -0.0482335 |
| RPL37A | ribosomal protein L37a | -0.0467411 |
| RPS19 | ribosomal protein S19 | -0.0462136 |
| ATP10A | ATPase, class V, type 10A | -0.0441073 |
| EGR1 | early growth response 1 | -0.0438802 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0435489 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.043523 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0434692 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0432185 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0426368 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0423021 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0416893 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0407131 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0398223 |
| FRMD5 | FERM domain containing 5 | -0.0391851 |
| RPL35A | ribosomal protein L35a | -0.038492 |
| RPL34 | ribosomal protein L34 | -0.0382769 |
| A2M | alpha-2-macroglobulin | -0.0370871 |
| TRIM26 | tripartite motif containing 26 | -0.0369978 |
| RPL9 | ribosomal protein L9 | -0.036553 |
| RIGI | RNA sensor RIG-I | -0.0364474 |
| ITGAV | integrin, alpha V | -0.0357627 |
| RPS21 | ribosomal protein S21 | -0.0355717 |
| APOE | apolipoprotein E | -0.0352403 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0347953 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0347155 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0343763 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0343667 |
| ZFHX3 | zinc finger homeobox 3 | -0.0339676 |
| TMEM123 | transmembrane protein 123 | -0.0333195 |
| NHSL1 | NHS-like 1 | -0.0330448 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0329654 |
| SYN3 | synapsin III | -0.0328747 |
| NPR2 | natriuretic peptide receptor 2 | -0.0322327 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0321526 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0320158 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0319502 |
| RPL38 | ribosomal protein L38 | -0.0318691 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0316574 |
| CALD1 | caldesmon 1 | -0.0310671 |
| RPS27A | ribosomal protein S27a | -0.0309847 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.03098 |
| RNF213 | ring finger protein 213 | -0.0309417 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.030589 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0299963 |
| PTMA | prothymosin, alpha | -0.0299051 |
| FTL | ferritin, light polypeptide | -0.0296539 |
| PTCHD4 | patched domain containing 4 | -0.0295765 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0291615 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0278827 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.027623 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0275797 |
| SLC2A14 | solute carrier family 2 (facilitated glucose transporter), member 14 | -0.0265967 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0263883 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0262232 |
| DST | dystonin | -0.0260868 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0259963 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0259607 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0258702 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.025751 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0253888 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0251026 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0249253 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.0248971 |
| RPL23 | ribosomal protein L23 | -0.0248512 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0247615 |
| CCDC146 | coiled-coil domain containing 146 | -0.0246262 |
| MIDN | midnolin | -0.0245346 |
| RPL36 | ribosomal protein L36 | -0.0240418 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0239079 |
| MX2 | MX dynamin-like GTPase 2 | -0.023476 |
| RPS6 | ribosomal protein S6 | -0.023396 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0233715 |
| DOK6 | docking protein 6 | -0.02337 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0231163 |
