Gemcitabine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemcitabine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemcitabine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.181628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.157275
ERRFI1 ERBB receptor feedback inhibitor 1 0.127423
CANX calnexin 0.110121
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.109085
MACF1 microtubule-actin crosslinking factor 1 0.10244
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.102076
TTC3 tetratricopeptide repeat domain 3 0.101388
CAPRIN2 caprin family member 2 0.0988188
EZR ezrin 0.0928563
CALR calreticulin 0.0856752
TMSB4X thymosin beta 4, X-linked 0.0808226
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0804446
TXNIP thioredoxin interacting protein 0.0765076
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0750834
ENO1 enolase 1, (alpha) 0.0697941
RUNX1 runt-related transcription factor 1 0.0692213
PSD3 pleckstrin and Sec7 domain containing 3 0.0686355
MYOF myoferlin 0.0684652
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0682146
TRIO trio Rho guanine nucleotide exchange factor 0.0674677
JUN jun proto-oncogene 0.0663151
WWTR1 WW domain containing transcription regulator 1 0.0655469
HDLBP high density lipoprotein binding protein 0.0654419
ARHGAP5 Rho GTPase activating protein 5 0.0628773
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0619772
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0617528
GOLGB1 golgin B1 0.0604503
CXCL8 chemokine (C-X-C motif) ligand 8 0.0590773
SPAG9 sperm associated antigen 9 0.0581108
SQSTM1 sequestosome 1 0.0550387
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0527188
RPS12 ribosomal protein S12 0.0506669
HOMER1 homer scaffolding protein 1 0.0499641
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0481271
LDHA lactate dehydrogenase A 0.0480427
ZSWIM6 zinc finger, SWIM-type containing 6 0.047727
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0472993
EREG epiregulin 0.0472706
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0461114
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0455148
BZW1 basic leucine zipper and W2 domains 1 0.0452017
TXNRD1 thioredoxin reductase 1 0.0451764
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0447886
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0442203
CAMTA1 calmodulin binding transcription activator 1 0.0435293
JMJD1C jumonji domain containing 1C 0.0430588
SEC31A SEC31 homolog A (S. cerevisiae) 0.0428744
BIRC3 baculoviral IAP repeat containing 3 0.0421052
SEC24A SEC24 family member A 0.0418222
IQGAP1 IQ motif containing GTPase activating protein 1 0.0409013
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0408637
PDIA4 protein disulfide isomerase family A, member 4 0.040529
RPS3 ribosomal protein S3 0.0400019
AFF4 AF4/FMR2 family, member 4 0.0397614
BCAR3 breast cancer anti-estrogen resistance 3 0.0391343
OSBPL8 oxysterol binding protein-like 8 0.0389877
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.038717
HSPA8 heat shock 70kDa protein 8 0.0380591
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0376464
CLTC clathrin, heavy chain (Hc) 0.0373471
KLF6 Kruppel-like factor 6 0.0373366
ZBTB38 zinc finger and BTB domain containing 38 0.0367124
RAP2B RAP2B, member of RAS oncogene family 0.0365819
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0363808
RPL4 ribosomal protein L4 0.0361831
GOLGA3 golgin A3 0.0355475
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.035122
RPL37 ribosomal protein L37 0.0348205
APP amyloid beta (A4) precursor protein 0.0346692
PLK2 polo-like kinase 2 0.0343337
SRRM2 serine/arginine repetitive matrix 2 0.034323
RPS8 ribosomal protein S8 0.0339223
RPL37A ribosomal protein L37a 0.0337909
LYST lysosomal trafficking regulator 0.033483
SND1 staphylococcal nuclease and tudor domain containing 1 0.0333086
ESYT2 extended synaptotagmin-like protein 2 0.0330845
UBC ubiquitin C 0.0326769
MORF4L2 mortality factor 4 like 2 0.0326639
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.032591
ANGPTL4 angiopoietin-like 4 0.0325776
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0324092
RPL31 ribosomal protein L31 0.0321406
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0320244
CAPN2 calpain 2, (m/II) large subunit 0.0315113
RPL26 ribosomal protein L26 0.0313817
TPT1 tumor protein, translationally-controlled 1 0.0307488
FMNL2 formin-like 2 0.0305989
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0305708
MT1E metallothionein 1E 0.030363
DPYSL2 dihydropyrimidinase-like 2 0.0299238
CSNK1A1 casein kinase 1, alpha 1 0.0298965
AHNAK AHNAK nucleoprotein 0.0298686
EMP1 epithelial membrane protein 1 0.0298374
EEF2 eukaryotic translation elongation factor 2 0.0298004
TM4SF1 transmembrane 4 L six family member 1 0.0297935
HOOK2 hook microtubule-tethering protein 2 0.0296378
SLK STE20-like kinase 0.0293238
ZFAND3 zinc finger, AN1-type domain 3 0.0290807
GDI2 GDP dissociation inhibitor 2 0.0290255

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.109176
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0960914
PTMA prothymosin, alpha -0.0855484
CENPF centromere protein F, 350/400kDa -0.0770166
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0758708
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0648639
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0642124
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0624798
RAD51B RAD51 paralog B -0.0612081
DLG1 discs, large homolog 1 (Drosophila) -0.0587215
SMC4 structural maintenance of chromosomes 4 -0.0576175
RIGI RNA sensor RIG-I -0.0514302
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0461429
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0442771
TMSB10 thymosin beta 10 -0.0440648
TP63 tumor protein p63 -0.0421875
CADM2 cell adhesion molecule 2 -0.0419877
MKI67 marker of proliferation Ki-67 -0.0415113
DPH6 diphthamine biosynthesis 6 -0.040438
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0400557
CFAP299 cilia and flagella associated protein 299 -0.039946
ADGRG6 adhesion G protein-coupled receptor G6 -0.0395525
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0392069
SRPK2 SRSF protein kinase 2 -0.0390657
RBM25 RNA binding motif protein 25 -0.0386548
DIAPH3 diaphanous-related formin 3 -0.0347939
SRGN serglycin -0.0345768
ZMYND8 zinc finger, MYND-type containing 8 -0.0334666
SBF2 SET binding factor 2 -0.0329744
WARS1 tryptophanyl-tRNA synthetase 1 -0.0329501
MT2A metallothionein 2A -0.0327311
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0319731
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.031884
ACTG1 actin gamma 1 -0.0305866
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0302071
MIS18BP1 MIS18 binding protein 1 -0.0301036
RRM2 ribonucleotide reductase M2 -0.0294973
XPO1 exportin 1 -0.0287515
BRWD1 bromodomain and WD repeat domain containing 1 -0.0279868
TTC28 tetratricopeptide repeat domain 28 -0.0279042
CALD1 caldesmon 1 -0.0277315
PNISR PNN-interacting serine/arginine-rich protein -0.0274091
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0270517
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0267442
ECT2 epithelial cell transforming 2 -0.0267248
PLSCR1 phospholipid scramblase 1 -0.0264957
PGAP1 post-GPI attachment to proteins 1 -0.0262959
VCL vinculin -0.0261635
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0260662
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0259226
BABAM2 BRISC and BRCA1 A complex member 2 -0.025428
ANLN anillin, actin binding protein -0.0248302
MT1X metallothionein 1X -0.0244407
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0241999
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0240752
TPX2 TPX2, microtubule-associated -0.0240099
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0237264
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0237096
NSD2 nuclear receptor binding SET domain protein 2 -0.0236522
TFB1M transcription factor B1, mitochondrial -0.0234726
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0232212
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0231567
POTEF POTE ankyrin domain family, member F -0.0230688
KIF14 kinesin family member 14 -0.0230683
KCMF1 potassium channel modulatory factor 1 -0.0229996
ZMIZ2 zinc finger, MIZ-type containing 2 -0.0228425
SRSF11 serine/arginine-rich splicing factor 11 -0.0228123
TAPBP TAP binding protein (tapasin) -0.0226844
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0222709
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0219272
YBX1 Y box binding protein 1 -0.0218586
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0218073
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0217758
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0216233
HMGB1 high mobility group box 1 -0.0214783
STRN3 striatin, calmodulin binding protein 3 -0.0214617
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.021451
PFN1 profilin 1 -0.0214309
CKAP2 cytoskeleton associated protein 2 -0.02143
TRA2A transformer 2 alpha homolog (Drosophila) -0.0213341
CENPE centromere protein E, 312kDa -0.0213336
AMBRA1 autophagy/beclin-1 regulator 1 -0.0211319
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0210659
POU2F1 POU class 2 homeobox 1 -0.0210411
RTN4 reticulon 4 -0.0208779
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0208559
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.0206357
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0206317
HMGB2 high mobility group box 2 -0.0206017
SPRY4 sprouty homolog 4 (Drosophila) -0.0201909
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0200659
SAMHD1 SAM domain and HD domain 1 -0.0199752
MTF2 metal response element binding transcription factor 2 -0.0198321
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.019775
ATP5F1B ATP synthase F1 subunit beta -0.0197442
MYADM myeloid-associated differentiation marker -0.0195766
PRRC2B proline-rich coiled-coil 2B -0.0194897
EXOC4 exocyst complex component 4 -0.0194856
HJURP Holliday junction recognition protein -0.0194667
ZMYM2 zinc finger, MYM-type 2 -0.0192195