| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Gemcitabine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Gemcitabine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.213785 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.202052 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.160555 |
| LMO7 | LIM domain 7 | 0.122296 |
| MYOF | myoferlin | 0.122194 |
| EGFR | epidermal growth factor receptor | 0.105929 |
| ENO1 | enolase 1, (alpha) | 0.0958669 |
| LAMC2 | laminin, gamma 2 | 0.0909321 |
| SMAD3 | SMAD family member 3 | 0.0893717 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0884108 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0808562 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0792061 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0772421 |
| GRAMD1B | GRAM domain containing 1B | 0.0755099 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0733819 |
| SLTM | SAFB-like, transcription modulator | 0.0733653 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0698111 |
| MCL1 | myeloid cell leukemia 1 | 0.0697383 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0671327 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0668795 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0663727 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0661266 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0647892 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0634434 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0633383 |
| HYOU1 | hypoxia up-regulated 1 | 0.0628537 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.061293 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0608897 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0593418 |
| LDHA | lactate dehydrogenase A | 0.0588115 |
| RAB10 | RAB10, member RAS oncogene family | 0.0585299 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0564355 |
| CANX | calnexin | 0.0547908 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0540419 |
| PKM | pyruvate kinase, muscle | 0.0533771 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0531871 |
| CES1 | carboxylesterase 1 | 0.0528238 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0521575 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0520975 |
| AREG | amphiregulin | 0.0508497 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0508403 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0504128 |
| LAMB3 | laminin, beta 3 | 0.0495405 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0483167 |
| MYO1E | myosin IE | 0.0478382 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0477156 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0464998 |
| ASPH | aspartate beta-hydroxylase | 0.046397 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0462983 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0458173 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.042516 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0417257 |
| TPM3 | tropomyosin 3 | 0.0409336 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0404994 |
| LAMA4 | laminin, alpha 4 | 0.040183 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0398728 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0398012 |
| TJP1 | tight junction protein 1 | 0.039547 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0381096 |
| GOLGB1 | golgin B1 | 0.0376454 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0361497 |
| STC2 | stanniocalcin 2 | 0.036036 |
| CALR | calreticulin | 0.0358398 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0354031 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0351129 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.034587 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0344929 |
| MYO5B | myosin VB | 0.0344797 |
| PLEC | plectin | 0.0335449 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0332684 |
| RPL4 | ribosomal protein L4 | 0.0332586 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0329195 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0327584 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0326726 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0326022 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0325688 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0322948 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0320472 |
| SON | SON DNA binding protein | 0.0319705 |
| TES | testin LIM domain protein | 0.0318871 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0317653 |
| SPAG9 | sperm associated antigen 9 | 0.0317628 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0314419 |
| VMP1 | vacuole membrane protein 1 | 0.0313921 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0311852 |
| HOMER1 | homer scaffolding protein 1 | 0.0310374 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0306125 |
| IER3 | immediate early response 3 | 0.0302242 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0300246 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0297274 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0292452 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0290515 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.029005 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0288791 |
| PMM2 | phosphomannomutase 2 | 0.0286504 |
| JUN | jun proto-oncogene | 0.028637 |
| HDLBP | high density lipoprotein binding protein | 0.0280085 |
| STC1 | stanniocalcin 1 | 0.0278876 |
| INTS6 | integrator complex subunit 6 | 0.0278142 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0272897 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.189092 |
| NDRG1 | N-myc downstream regulated 1 | -0.174885 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.124627 |
| TMSB10 | thymosin beta 10 | -0.124292 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.10035 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.091858 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0800776 |
| FAM13A | family with sequence similarity 13, member A | -0.0661536 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0643437 |
| RPS3 | ribosomal protein S3 | -0.0623757 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0571248 |
| RPL35A | ribosomal protein L35a | -0.0563314 |
| PTMA | prothymosin, alpha | -0.0553623 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.053001 |
| MKI67 | marker of proliferation Ki-67 | -0.0499751 |
| GPC6 | glypican 6 | -0.0493304 |
| RPL37A | ribosomal protein L37a | -0.0491763 |
| SCEL | sciellin | -0.0477633 |
| TMEM165 | transmembrane protein 165 | -0.0451545 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.044335 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0420984 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0407401 |
| TPD52 | tumor protein D52 | -0.0407266 |
| CPE | carboxypeptidase E | -0.0401655 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0384109 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0381726 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0379087 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0376945 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0348684 |
| RPS8 | ribosomal protein S8 | -0.0337114 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0334292 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0333396 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0320523 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0318205 |
| NGLY1 | N-glycanase 1 | -0.0313234 |
| RPS27A | ribosomal protein S27a | -0.0311672 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0307984 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0307861 |
| KRT7 | keratin 7, type II | -0.0307841 |
| DOCK5 | dedicator of cytokinesis 5 | -0.029928 |
| SEC61G | Sec61 gamma subunit | -0.0299102 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0298505 |
| RPL9 | ribosomal protein L9 | -0.0298412 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0296478 |
| S100P | S100 calcium binding protein P | -0.0294477 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0291632 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0279878 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0279233 |
| BBX | bobby sox homolog (Drosophila) | -0.0279017 |
| RPL31 | ribosomal protein L31 | -0.0278961 |
| EFNA5 | ephrin-A5 | -0.0278057 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0275225 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0275161 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0273126 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0273067 |
| RPL19 | ribosomal protein L19 | -0.0268559 |
| CUX1 | cut-like homeobox 1 | -0.0268068 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0261988 |
| TBC1D22A | TBC1 domain family, member 22A | -0.026158 |
| GNAS | GNAS complex locus | -0.0261246 |
| FTL | ferritin, light polypeptide | -0.0259331 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0256623 |
| CST3 | cystatin C | -0.0252856 |
| RPS21 | ribosomal protein S21 | -0.0252284 |
| PERP | PERP, TP53 apoptosis effector | -0.0251635 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0250924 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0250278 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0246471 |
| MAP7 | microtubule-associated protein 7 | -0.0245296 |
| SBF2 | SET binding factor 2 | -0.0244301 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0244297 |
| DENND5B | DENN/MADD domain containing 5B | -0.0242368 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.024212 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0239406 |
| PDGFC | platelet derived growth factor C | -0.0238438 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0237515 |
| TNS3 | tensin 3 | -0.0234571 |
| RPS13 | ribosomal protein S13 | -0.0234239 |
| RNF145 | ring finger protein 145 | -0.0232858 |
| RPL36 | ribosomal protein L36 | -0.0232612 |
| HMGA1 | high mobility group AT-hook 1 | -0.0229841 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.022481 |
| OGA | O-GlcNAcase | -0.0224655 |
| WDR45B | WD repeat domain 45B | -0.0224502 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0221581 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0219024 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0217467 |
| PDE8A | phosphodiesterase 8A | -0.0216773 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0216755 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0216655 |
| RPL5 | ribosomal protein L5 | -0.0214664 |
| PRKCA | protein kinase C, alpha | -0.0213953 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0212696 |
| S100A9 | S100 calcium binding protein A9 | -0.0211737 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0211565 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0210251 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0210248 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0208046 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0207294 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0206759 |
