| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Gemcitabine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Gemcitabine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.227857 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.220978 |
| KYNU | kynureninase | 0.148708 |
| EXT1 | exostosin glycosyltransferase 1 | 0.125112 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.114717 |
| MMP1 | matrix metallopeptidase 1 | 0.112726 |
| POTEF | POTE ankyrin domain family, member F | 0.110048 |
| TXNRD1 | thioredoxin reductase 1 | 0.108248 |
| EFNA5 | ephrin-A5 | 0.0977296 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0976509 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0864092 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0820051 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0760745 |
| STC2 | stanniocalcin 2 | 0.0744055 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.068584 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0680539 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.064413 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0625057 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0622765 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0614109 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0609666 |
| GOLGA4 | golgin A4 | 0.0605521 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0594426 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0593611 |
| TJP1 | tight junction protein 1 | 0.0586874 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0582953 |
| UBC | ubiquitin C | 0.0564057 |
| RACK1 | receptor for activated C kinase 1 | 0.0558302 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0557583 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0546717 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0538263 |
| SMAD3 | SMAD family member 3 | 0.0524369 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0524139 |
| CLIC4 | chloride intracellular channel 4 | 0.052363 |
| KRT17 | keratin 17, type I | 0.051719 |
| RPL37A | ribosomal protein L37a | 0.0513072 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0502011 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0499114 |
| RASA2 | RAS p21 protein activator 2 | 0.0489324 |
| BRD4 | bromodomain containing 4 | 0.0487493 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0475014 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0470005 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0467399 |
| COL6A3 | collagen, type VI, alpha 3 | 0.046049 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0459442 |
| KIF5B | kinesin family member 5B | 0.0458163 |
| YTHDC1 | YTH domain containing 1 | 0.0453515 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.044911 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0447127 |
| MYO5B | myosin VB | 0.0446501 |
| RND3 | Rho family GTPase 3 | 0.0445642 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0437915 |
| EZR | ezrin | 0.0437394 |
| RPS27A | ribosomal protein S27a | 0.0436721 |
| H1-0 | H1.0 linker histone | 0.0433201 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0429663 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0428707 |
| PKM | pyruvate kinase, muscle | 0.0428701 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0427629 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.042508 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0422966 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0411787 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0409543 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0408682 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.04085 |
| TPM4 | tropomyosin 4 | 0.0405453 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0404357 |
| MYO1E | myosin IE | 0.0403593 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0399793 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0397951 |
| RHOA | ras homolog family member A | 0.03955 |
| ACTN4 | actinin, alpha 4 | 0.0393519 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.0388923 |
| RPS12 | ribosomal protein S12 | 0.0388338 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.038705 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0385369 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0381229 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0378562 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0376876 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0375345 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0374614 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0371848 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0371749 |
| TLK1 | tousled-like kinase 1 | 0.0368614 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0363312 |
| RCOR1 | REST corepressor 1 | 0.0363085 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0359853 |
| DUSP10 | dual specificity phosphatase 10 | 0.0358843 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0356034 |
| VMP1 | vacuole membrane protein 1 | 0.0355864 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0352898 |
| EXOC6B | exocyst complex component 6B | 0.0350429 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0349056 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0349053 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0344874 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.034408 |
| VEGFA | vascular endothelial growth factor A | 0.0343711 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0341456 |
| SON | SON DNA binding protein | 0.0340247 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0339998 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.103722 |
| FN1 | fibronectin 1 | -0.0997639 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0912742 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0832544 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0829998 |
| VIM | vimentin | -0.0822334 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0815241 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0764126 |
| PTMA | prothymosin, alpha | -0.0762265 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0730633 |
| SVIL | supervillin | -0.0691731 |
| SLTM | SAFB-like, transcription modulator | -0.0686252 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0685332 |
| OGA | O-GlcNAcase | -0.0676055 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0637607 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0612408 |
| JMJD1C | jumonji domain containing 1C | -0.0600884 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0593225 |
| SMYD3 | SET and MYND domain containing 3 | -0.0585217 |
| YAP1 | Yes-associated protein 1 | -0.0567194 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0560629 |
| EGFR | epidermal growth factor receptor | -0.0557551 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0538689 |
| TMSB10 | thymosin beta 10 | -0.051182 |
| FTL | ferritin, light polypeptide | -0.0507723 |
| NAV2 | neuron navigator 2 | -0.0504275 |
| ATOSA | atos homolog A | -0.049345 |
| ERBIN | erbb2 interacting protein | -0.0492241 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0492171 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0487833 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0485777 |
| MT2A | metallothionein 2A | -0.0468159 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0467638 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0457373 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0454432 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0451341 |
| NDRG1 | N-myc downstream regulated 1 | -0.0446864 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0446774 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0445432 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0445295 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0442377 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0440283 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0439552 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0434256 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0433039 |
| CYTH1 | cytohesin 1 | -0.0429573 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0424819 |
| RPL11 | ribosomal protein L11 | -0.0424522 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0415834 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0415625 |
| THOC2 | THO complex 2 | -0.040874 |
| PRKCA | protein kinase C, alpha | -0.0404522 |
| HMGA2 | high mobility group AT-hook 2 | -0.0404255 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0400347 |
| KRT19 | keratin 19, type I | -0.0400045 |
| MSI2 | musashi RNA-binding protein 2 | -0.0399263 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.039532 |
| RPL35A | ribosomal protein L35a | -0.03947 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0394615 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0384537 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0383319 |
| CALU | calumenin | -0.0381389 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0379053 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0378562 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0378411 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0374854 |
| RAD51B | RAD51 paralog B | -0.0374588 |
| WDR45B | WD repeat domain 45B | -0.0371347 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0370919 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0370837 |
| SLMAP | sarcolemma associated protein | -0.0368188 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0367975 |
| SPAG9 | sperm associated antigen 9 | -0.0366349 |
| USP3 | ubiquitin specific peptidase 3 | -0.0365173 |
| PHF3 | PHD finger protein 3 | -0.0364822 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0364376 |
| MEF2A | myocyte enhancer factor 2A | -0.0364175 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0362006 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0359519 |
| ZNF638 | zinc finger protein 638 | -0.0357169 |
| BPTF | bromodomain PHD finger transcription factor | -0.0355614 |
| HMGA1 | high mobility group AT-hook 1 | -0.035508 |
| FMN1 | formin 1 | -0.0354918 |
| RPS21 | ribosomal protein S21 | -0.0354541 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0352058 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0347206 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0346658 |
| GPATCH8 | G patch domain containing 8 | -0.0346566 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.0346073 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0346021 |
| PHF21A | PHD finger protein 21A | -0.0345061 |
| NF1 | neurofibromin 1 | -0.0343205 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0341065 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0339248 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0339184 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0338393 |
| RPL23 | ribosomal protein L23 | -0.0336453 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0335842 |
| LMO7 | LIM domain 7 | -0.033543 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0334657 |
