Gemcitabine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemcitabine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemcitabine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.132486
USP34 ubiquitin specific peptidase 34 0.124519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.12442
RUNX1 runt-related transcription factor 1 0.11275
NAP1L1 nucleosome assembly protein 1-like 1 0.111002
RPS16 ribosomal protein S16 0.108746
TXNRD1 thioredoxin reductase 1 0.100782
RPLP1 ribosomal protein, large, P1 0.0967591
RPS6 ribosomal protein S6 0.0878088
RPS3 ribosomal protein S3 0.0809052
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.079826
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0771593
FTH1 ferritin, heavy polypeptide 1 0.0750852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0707029
RPS12 ribosomal protein S12 0.0698315
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0693859
RPL11 ribosomal protein L11 0.0686959
ENO1 enolase 1, (alpha) 0.0683914
CTNND1 catenin (cadherin-associated protein), delta 1 0.0681177
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0667461
RPL35A ribosomal protein L35a 0.063094
FTL ferritin, light polypeptide 0.0593256
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0585038
RPLP0 ribosomal protein, large, P0 0.0583166
AKAP12 A kinase (PRKA) anchor protein 12 0.056252
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0554626
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0550003
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0538698
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0520952
CDK6 cyclin-dependent kinase 6 0.0516457
RPLP2 ribosomal protein, large, P2 0.0514302
JMJD1C jumonji domain containing 1C 0.0508225
EEF2 eukaryotic translation elongation factor 2 0.0507962
ARHGAP12 Rho GTPase activating protein 12 0.0504427
PKM pyruvate kinase, muscle 0.0503533
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0498264
RPL4 ribosomal protein L4 0.0495408
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0487973
ZCCHC7 zinc finger, CCHC domain containing 7 0.0485102
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0476056
RPL19 ribosomal protein L19 0.0459863
DTNA dystrobrevin, alpha 0.0446797
DSCAM Down syndrome cell adhesion molecule 0.0440479
ABI1 abl-interactor 1 0.0440157
FNDC3A fibronectin type III domain containing 3A 0.043841
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0428371
RPS17 ribosomal protein S17 0.0428198
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0425733
PTPRK protein tyrosine phosphatase, receptor type, K 0.0424232
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0421436
SEPTIN9 septin 9 0.041935
MAP2K1 mitogen-activated protein kinase kinase 1 0.0417613
ARHGAP5 Rho GTPase activating protein 5 0.0414763
RPS27 ribosomal protein S27 0.0409475
PHF14 PHD finger protein 14 0.040939
SBF2 SET binding factor 2 0.0406479
LMO7 LIM domain 7 0.0403797
ADAR adenosine deaminase, RNA-specific 0.0403417
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.04028
DENND1A DENN/MADD domain containing 1A 0.0402203
RPS20 ribosomal protein S20 0.0397086
TNIK TRAF2 and NCK interacting kinase 0.0394307
NAV2 neuron navigator 2 0.0394159
NCOR1 nuclear receptor corepressor 1 0.0390611
KIF13A kinesin family member 13A 0.0383984
KLHL29 kelch-like family member 29 0.037483
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0371909
EXOC6B exocyst complex component 6B 0.0369761
ETNK1 ethanolamine kinase 1 0.0355616
NKD1 naked cuticle homolog 1 (Drosophila) 0.0348014
KTN1 kinectin 1 (kinesin receptor) 0.0345868
TNRC6B trinucleotide repeat containing 6B 0.0344736
MSR1 macrophage scavenger receptor 1 0.0341715
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0337958
RPL37 ribosomal protein L37 0.0336344
TPR translocated promoter region, nuclear basket protein 0.0333868
SH3D19 SH3 domain containing 19 0.0333848
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0329966
RPL26 ribosomal protein L26 0.0329425
CADPS Ca++-dependent secretion activator 0.0327757
EZR ezrin 0.0326482
B2M beta-2-microglobulin 0.0325171
APP amyloid beta (A4) precursor protein 0.032517
RPS8 ribosomal protein S8 0.0325017
ANO6 anoctamin 6 0.0318034
RACK1 receptor for activated C kinase 1 0.0317805
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0317434
KLF5 Kruppel-like factor 5 (intestinal) 0.0316091
RPL37A ribosomal protein L37a 0.0315354
RPL5 ribosomal protein L5 0.0311957
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0311775
HDAC4 histone deacetylase 4 0.031172
PIBF1 progesterone immunomodulatory binding factor 1 0.0304596
SRSF11 serine/arginine-rich splicing factor 11 0.0303574
THSD4 thrombospondin, type I, domain containing 4 0.029971
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0294146
CSNK1A1 casein kinase 1, alpha 1 0.0293475
DST dystonin 0.0292115
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0285229
NIPBL Nipped-B homolog (Drosophila) 0.0283453

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266956
NDRG1 N-myc downstream regulated 1 -0.146694
VIM vimentin -0.128425
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.1203
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.117636
FN1 fibronectin 1 -0.110232
CDH13 cadherin 13 -0.0845906
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0816845
TMSB10 thymosin beta 10 -0.0795354
EFNA5 ephrin-A5 -0.0788883
GPC6 glypican 6 -0.0774439
EGR1 early growth response 1 -0.0756919
PRKCA protein kinase C, alpha -0.0694202
LAMA4 laminin, alpha 4 -0.0693489
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0683417
LAMC2 laminin, gamma 2 -0.0674453
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0665299
HMGA2 high mobility group AT-hook 2 -0.0642805
NAMPT nicotinamide phosphoribosyltransferase -0.0639804
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0638945
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0631441
PARD3 par-3 family cell polarity regulator -0.0617069
PSD3 pleckstrin and Sec7 domain containing 3 -0.0610949
ARHGAP26 Rho GTPase activating protein 26 -0.0597591
ACTG1 actin gamma 1 -0.0592156
LAMB3 laminin, beta 3 -0.058217
TM9SF3 transmembrane 9 superfamily member 3 -0.0581857
DLG1 discs, large homolog 1 (Drosophila) -0.0580608
FHIT fragile histidine triad -0.0571238
AKAP13 A kinase (PRKA) anchor protein 13 -0.0568117
HDAC9 histone deacetylase 9 -0.0562244
HDLBP high density lipoprotein binding protein -0.0552693
COL5A1 collagen, type V, alpha 1 -0.0545222
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0539233
RAD51B RAD51 paralog B -0.0534332
ALCAM activated leukocyte cell adhesion molecule -0.0527978
TJP1 tight junction protein 1 -0.0522458
NPEPPS aminopeptidase puromycin sensitive -0.0521999
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0520789
RPL15 ribosomal protein L15 -0.0509371
FAM13A family with sequence similarity 13, member A -0.050119
MYOF myoferlin -0.0498837
IGFBP3 insulin-like growth factor binding protein 3 -0.049459
COL6A1 collagen, type VI, alpha 1 -0.0492485
YAP1 Yes-associated protein 1 -0.0491972
DOCK5 dedicator of cytokinesis 5 -0.0491298
PTK2 protein tyrosine kinase 2 -0.0477108
MYO1E myosin IE -0.0474583
TTC3 tetratricopeptide repeat domain 3 -0.0473164
RAB1A RAB1A, member RAS oncogene family -0.0461579
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0452882
TMEM165 transmembrane protein 165 -0.0450852
NFIA nuclear factor I/A -0.0444652
TENM3 teneurin transmembrane protein 3 -0.044434
ANTXR2 anthrax toxin receptor 2 -0.044066
USP3 ubiquitin specific peptidase 3 -0.0431065
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0424296
CLTC clathrin, heavy chain (Hc) -0.0422995
ITCH itchy E3 ubiquitin protein ligase -0.041791
RTN4 reticulon 4 -0.0411379
SEC31A SEC31 homolog A (S. cerevisiae) -0.0403233
CALU calumenin -0.0393508
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0391822
OLA1 Obg-like ATPase 1 -0.0378615
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0373626
PRELID2 PRELI domain containing 2 -0.0372888
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0372682
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0366948
ZBTB20 zinc finger and BTB domain containing 20 -0.0366606
COL1A1 collagen, type I, alpha 1 -0.0366223
SH3KBP1 SH3-domain kinase binding protein 1 -0.0356388
TPD52 tumor protein D52 -0.0351688
MACF1 microtubule-actin crosslinking factor 1 -0.0347148
MYO10 myosin X -0.0344067
KMT2C lysine (K)-specific methyltransferase 2C -0.0343975
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0342025
PCBP2 poly(rC) binding protein 2 -0.03384
PTPRM protein tyrosine phosphatase, receptor type, M -0.0336155
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0335247
MON2 MON2 homolog (S. cerevisiae) -0.0331486
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0330923
AREG amphiregulin -0.0328703
FNDC3B fibronectin type III domain containing 3B -0.0328092
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0326353
SETD5 SET domain containing 5 -0.0325453
CDK13 cyclin-dependent kinase 13 -0.0323988
DOCK4 dedicator of cytokinesis 4 -0.0319135
PDE10A phosphodiesterase 10A -0.0318969
SAMD4A sterile alpha motif domain containing 4A -0.0316592
RPL32 ribosomal protein L32 -0.0315427
RORA RAR-related orphan receptor A -0.0314173
RB1CC1 RB1-inducible coiled-coil 1 -0.0313661
EIF1 eukaryotic translation initiation factor 1 -0.0306087
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303397
RBM25 RNA binding motif protein 25 -0.03
TBC1D5 TBC1 domain family, member 5 -0.0297768
LIMCH1 LIM and calponin homology domains 1 -0.0297462
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.029626
CHD9 chromodomain helicase DNA binding protein 9 -0.0295127
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.029453