Gemcitabine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemcitabine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemcitabine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.301427
HDAC9 histone deacetylase 9 0.127347
COL3A1 collagen, type III, alpha 1 0.126463
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.124494
PCLO piccolo presynaptic cytomatrix protein 0.105617
CALR calreticulin 0.0879165
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0831542
TENM3 teneurin transmembrane protein 3 0.0803786
PARD3B par-3 family cell polarity regulator beta 0.0792222
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0773528
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0736706
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.071224
CADM2 cell adhesion molecule 2 0.0692202
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0669377
COL5A2 collagen, type V, alpha 2 0.0658492
ANK2 ankyrin 2, neuronal 0.0654288
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0617375
LDHA lactate dehydrogenase A 0.0596148
DST dystonin 0.057133
ZEB2 zinc finger E-box binding homeobox 2 0.0565742
CDH19 cadherin 19, type 2 0.0565065
ADGRL2 adhesion G protein-coupled receptor L2 0.0561628
KDM3A lysine (K)-specific demethylase 3A 0.0556913
FNDC3B fibronectin type III domain containing 3B 0.0555708
ADGRV1 adhesion G protein-coupled receptor V1 0.0554252
UTRN utrophin 0.0543281
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0541242
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0517498
NCAM2 neural cell adhesion molecule 2 0.0508847
TRPS1 trichorhinophalangeal syndrome I 0.0495599
APLP2 amyloid beta (A4) precursor-like protein 2 0.0488324
TJP1 tight junction protein 1 0.0453159
SRRM2 serine/arginine repetitive matrix 2 0.044345
USP34 ubiquitin specific peptidase 34 0.0441625
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0426692
CHD1 chromodomain helicase DNA binding protein 1 0.0423464
ANKRD33B ankyrin repeat domain 33B 0.0421042
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0420498
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.041739
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0412504
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0408245
MED13L mediator complex subunit 13-like 0.0408082
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0406744
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0405735
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0390984
SPAG9 sperm associated antigen 9 0.0389736
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0389392
NHSL1 NHS-like 1 0.0387287
SLIT2 slit homolog 2 (Drosophila) 0.0385865
SAMD4A sterile alpha motif domain containing 4A 0.03858
HMCN1 hemicentin 1 0.0384467
RIMS2 regulating synaptic membrane exocytosis 2 0.0380277
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0379056
XPO1 exportin 1 0.0377597
JMJD1C jumonji domain containing 1C 0.0376069
SPIDR scaffolding protein involved in DNA repair 0.0368745
SREBF2 sterol regulatory element binding transcription factor 2 0.036822
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0366971
ADGRL3 adhesion G protein-coupled receptor L3 0.0364066
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0362205
ARB2A ARB2 cotranscriptional regulator A 0.0360988
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0360354
PHF21A PHD finger protein 21A 0.0356438
PCBP2 poly(rC) binding protein 2 0.0355441
SOX5 SRY (sex determining region Y)-box 5 0.0353721
IFRD1 interferon-related developmental regulator 1 0.0353248
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0352608
ERBIN erbb2 interacting protein 0.0351371
PDIA6 protein disulfide isomerase family A, member 6 0.0347132
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0346824
CSNK1A1 casein kinase 1, alpha 1 0.0345711
TPR translocated promoter region, nuclear basket protein 0.0344424
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.03401
NFIB nuclear factor I/B 0.0339095
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.033617
NFE2L1 nuclear factor, erythroid 2-like 1 0.0335775
ITSN2 intersectin 2 0.0333874
JUN jun proto-oncogene 0.0332791
THBS1 thrombospondin 1 0.0332396
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0330406
PRRC2C proline-rich coiled-coil 2C 0.0329686
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.032882
SKIL SKI-like proto-oncogene 0.0328773
MACF1 microtubule-actin crosslinking factor 1 0.0327939
PICALM phosphatidylinositol binding clathrin assembly protein 0.0325757
RASAL2 RAS protein activator like 2 0.0324646
NTM neurotrimin 0.0320875
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0319038
GPC4 glypican 4 0.0314226
DDIT4 DNA-damage-inducible transcript 4 0.0313025
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0311168
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0308752
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0307578
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0307191
WWOX WW domain containing oxidoreductase 0.0305488
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0304553
RPS3 ribosomal protein S3 0.0304462
WWC2 WW and C2 domain containing 2 0.0303414
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303047
ZFAND3 zinc finger, AN1-type domain 3 0.0301627

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.109443
VIM vimentin -0.0701444
ATP5F1B ATP synthase F1 subunit beta -0.0687701
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.058743
RPS16 ribosomal protein S16 -0.0567326
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0567136
TPT1 tumor protein, translationally-controlled 1 -0.0531834
MDK midkine (neurite growth-promoting factor 2) -0.0416336
CENPE centromere protein E, 312kDa -0.041626
ACTG1 actin gamma 1 -0.0408253
PNISR PNN-interacting serine/arginine-rich protein -0.0403941
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0379005
EMP1 epithelial membrane protein 1 -0.0378421
RIGI RNA sensor RIG-I -0.0376093
CAVIN1 caveolae associated protein 1 -0.0369571
VCL vinculin -0.036613
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0364487
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0358174
RPL35A ribosomal protein L35a -0.035409
RPL7A ribosomal protein L7a -0.0350626
CKAP5 cytoskeleton associated protein 5 -0.0350499
RPL31 ribosomal protein L31 -0.034557
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0338549
ZC3H15 zinc finger CCCH-type containing 15 -0.0330354
CENPF centromere protein F, 350/400kDa -0.0324989
CALU calumenin -0.031862
RPS10 ribosomal protein S10 -0.0316512
RPS29 ribosomal protein S29 -0.0312826
RPS24 ribosomal protein S24 -0.0306946
RPLP2 ribosomal protein, large, P2 -0.0304128
RPL37 ribosomal protein L37 -0.0294318
TPM1 tropomyosin 1 (alpha) -0.0293912
S100A10 S100 calcium binding protein A10 -0.0289719
PGAP1 post-GPI attachment to proteins 1 -0.0288785
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0284926
TMSB10 thymosin beta 10 -0.0284082
RPS21 ribosomal protein S21 -0.0282461
H1-4 H1.4 linker histone, cluster member -0.0280114
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0279924
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0272593
MCTP1 multiple C2 domains, transmembrane 1 -0.0271238
SIK2 salt-inducible kinase 2 -0.0271205
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0268104
ADNP activity-dependent neuroprotector homeobox -0.0266794
RPS27A ribosomal protein S27a -0.0266687
GPC3 glypican 3 -0.0266598
TPX2 TPX2, microtubule-associated -0.0266032
RPL38 ribosomal protein L38 -0.0265379
TBCA tubulin folding cofactor A -0.0261727
ADAM9 ADAM metallopeptidase domain 9 -0.0261054
HMGN3 high mobility group nucleosomal binding domain 3 -0.0251913
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0248558
RPS15 ribosomal protein S15 -0.0248037
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.024716
HMGA1 high mobility group AT-hook 1 -0.0247079
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0246076
RHEB Ras homolog enriched in brain -0.0244368
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0243185
ZBTB20 zinc finger and BTB domain containing 20 -0.0241519
CKAP2 cytoskeleton associated protein 2 -0.024052
QKI QKI, KH domain containing, RNA binding -0.0237847
PFN1 profilin 1 -0.0236523
LYST lysosomal trafficking regulator -0.023464
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0233986
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231965
RPL9 ribosomal protein L9 -0.0231829
SEPTIN10 septin 10 -0.0229386
WSB1 WD repeat and SOCS box containing 1 -0.0228704
H1-0 H1.0 linker histone -0.0228031
NAP1L4 nucleosome assembly protein 1-like 4 -0.0227771
FLNB filamin B, beta -0.0227603
TXNRD1 thioredoxin reductase 1 -0.0226993
FNBP4 formin binding protein 4 -0.0226966
RPL34 ribosomal protein L34 -0.0224062
MYL12B myosin, light chain 12B, regulatory -0.0223941
TCEA1 transcription elongation factor A (SII), 1 -0.0223216
PRR11 proline rich 11 -0.0221937
NRG1 neuregulin 1 -0.0221543
MIS18BP1 MIS18 binding protein 1 -0.0221385
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0221096
PCDH17 protocadherin 17 -0.0220795
KPNB1 karyopherin (importin) beta 1 -0.0219064
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0217545
MYADM myeloid-associated differentiation marker -0.0217188
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0216865
SRSF11 serine/arginine-rich splicing factor 11 -0.0214198
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0213923
ARHGAP15 Rho GTPase activating protein 15 -0.0210752
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0209961
WDR33 WD repeat domain 33 -0.0209409
SMC4 structural maintenance of chromosomes 4 -0.0208933
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0207745
CENATAC centrosomal AT-AC splicing factor -0.0207609
UGCG UDP-glucose ceramide glucosyltransferase -0.0207352
S100A6 S100 calcium binding protein A6 -0.0207106
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0206599
PKP4 plakophilin 4 -0.0206483
RPS25 ribosomal protein S25 -0.0206437
URI1 URI1, prefoldin-like chaperone -0.0205165
USP3 ubiquitin specific peptidase 3 -0.0204793