Gemfibrozil_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.272318
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.268332
RRM2 ribonucleotide reductase M2 0.118455
YAP1 Yes-associated protein 1 0.099281
PDE4D phosphodiesterase 4D, cAMP-specific 0.0884677
HMGA2 high mobility group AT-hook 2 0.0845275
RAB7A RAB7A, member RAS oncogene family 0.0809919
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0715377
ZSWIM6 zinc finger, SWIM-type containing 6 0.0707991
LDHA lactate dehydrogenase A 0.0634174
ADIPOR2 adiponectin receptor 2 0.0591793
INTS6 integrator complex subunit 6 0.0579517
SMC4 structural maintenance of chromosomes 4 0.0573522
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0560175
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.05571
ACTG1 actin gamma 1 0.0518491
ASPH aspartate beta-hydroxylase 0.0513738
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0507015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0505914
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0469911
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.045892
NAP1L1 nucleosome assembly protein 1-like 1 0.0450826
UBC ubiquitin C 0.0443889
BRD2 bromodomain containing 2 0.0434343
ZNF638 zinc finger protein 638 0.0426076
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0422353
CSNK1A1 casein kinase 1, alpha 1 0.0413455
RTN4 reticulon 4 0.0411494
DENND5A DENN/MADD domain containing 5A 0.0409826
TPM3 tropomyosin 3 0.0406154
HSPH1 heat shock 105kDa/110kDa protein 1 0.0398683
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0393993
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0390317
DIAPH3 diaphanous-related formin 3 0.0386904
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0385549
SET SET nuclear proto-oncogene 0.0382051
TPR translocated promoter region, nuclear basket protein 0.0380669
APLP2 amyloid beta (A4) precursor-like protein 2 0.0374051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0372821
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0370987
TPX2 TPX2, microtubule-associated 0.0358592
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.035847
EIF4A2 eukaryotic translation initiation factor 4A2 0.0357829
TPI1 triosephosphate isomerase 1 0.0357539
MBD5 methyl-CpG binding domain protein 5 0.0357216
OSBPL8 oxysterol binding protein-like 8 0.0356381
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0355705
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0353254
ZEB1 zinc finger E-box binding homeobox 1 0.0352921
PRELID2 PRELI domain containing 2 0.0348315
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0347186
GSK3B glycogen synthase kinase 3 beta 0.0341285
ENO1 enolase 1, (alpha) 0.0340391
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0338571
RCOR1 REST corepressor 1 0.033501
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0333208
ATAD2 ATPase family, AAA domain containing 2 0.0328375
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0327135
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0326834
GOLGB1 golgin B1 0.0325254
POTEF POTE ankyrin domain family, member F 0.0323956
TUBA1B tubulin, alpha 1b 0.0323592
ANKRD17 ankyrin repeat domain 17 0.0316351
MACF1 microtubule-actin crosslinking factor 1 0.0315064
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0311713
CTNND1 catenin (cadherin-associated protein), delta 1 0.0309342
PCM1 pericentriolar material 1 0.0308922
USP53 ubiquitin specific peptidase 53 0.0307598
FNIP1 folliculin interacting protein 1 0.0300779
INTS4 integrator complex subunit 4 0.0299758
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0298756
LPP LIM domain containing preferred translocation partner in lipoma 0.029701
MED13 mediator complex subunit 13 0.0295787
JMJD1C jumonji domain containing 1C 0.029492
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0294737
WWOX WW domain containing oxidoreductase 0.0288273
SPDYA speedy/RINGO cell cycle regulator family member A 0.0285289
TRA2B transformer 2 beta homolog (Drosophila) 0.0281365
HSPA8 heat shock 70kDa protein 8 0.0281087
VMP1 vacuole membrane protein 1 0.0275088
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0274424
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.02741
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.02712
TTC3 tetratricopeptide repeat domain 3 0.0269013
TAS2R14 taste receptor, type 2, member 14 0.0267933
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.02677
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0264486
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0264441
SON SON DNA binding protein 0.0263789
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0262392
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0262353
SDK1 sidekick cell adhesion molecule 1 0.0260343
KDM4C lysine (K)-specific demethylase 4C 0.0259629
KTN1 kinectin 1 (kinesin receptor) 0.0259226
CALR calreticulin 0.0256903
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0253269
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0252594
H3-3B H3.3 histone B 0.025199
USP9X ubiquitin specific peptidase 9, X-linked 0.0251561
HELLS helicase, lymphoid-specific 0.0250041

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.226965
TMSB10 thymosin beta 10 -0.156519
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.127728
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0790742
DPYD dihydropyrimidine dehydrogenase -0.0787005
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0748297
RPS6 ribosomal protein S6 -0.0709299
CELF2 CUGBP, Elav-like family member 2 -0.07023
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0688034
RPL35A ribosomal protein L35a -0.0683529
RPLP1 ribosomal protein, large, P1 -0.0639065
PCDH7 protocadherin 7 -0.0618815
RPS19 ribosomal protein S19 -0.0614759
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0613025
CNRIP1 cannabinoid receptor interacting protein 1 -0.0590328
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.058798
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0581746
MYL12B myosin, light chain 12B, regulatory -0.0566721
RPL23 ribosomal protein L23 -0.0540312
NLGN1 neuroligin 1 -0.0520593
RPL36 ribosomal protein L36 -0.0515146
SYT1 synaptotagmin I -0.049097
FTL ferritin, light polypeptide -0.0487329
RPL34 ribosomal protein L34 -0.0482775
RPS27 ribosomal protein S27 -0.0480097
RPS16 ribosomal protein S16 -0.0473987
RASAL2 RAS protein activator like 2 -0.0472226
RPL19 ribosomal protein L19 -0.0461202
S100A6 S100 calcium binding protein A6 -0.0455778
RPL37A ribosomal protein L37a -0.0444396
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0438607
RPS23 ribosomal protein S23 -0.0430896
RPS14 ribosomal protein S14 -0.042917
RPL8 ribosomal protein L8 -0.0428885
EIF1 eukaryotic translation initiation factor 1 -0.0421066
ZBTB20 zinc finger and BTB domain containing 20 -0.0414037
RPS21 ribosomal protein S21 -0.0408628
RPL12 ribosomal protein L12 -0.0379346
RPL36A ribosomal protein L36a -0.0376093
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0371829
DLC1 DLC1 Rho GTPase activating protein -0.035736
CMIP c-Maf inducing protein -0.0348738
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0344645
RPS29 ribosomal protein S29 -0.03396
LARP1 La ribonucleoprotein domain family, member 1 -0.033768
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0330986
RPS8 ribosomal protein S8 -0.0329397
CXADR coxsackie virus and adenovirus receptor -0.0326068
RPLP2 ribosomal protein, large, P2 -0.0321812
RPL38 ribosomal protein L38 -0.0310034
AHNAK AHNAK nucleoprotein -0.0304084
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0300404
RPL28 ribosomal protein L28 -0.0297347
WDR43 WD repeat domain 43 -0.0296994
PRR16 proline rich 16 -0.0296803
HSPB1 heat shock 27kDa protein 1 -0.0295249
RPS12 ribosomal protein S12 -0.0286537
RPL11 ribosomal protein L11 -0.0284361
RPL27A ribosomal protein L27a -0.0281771
RPS20 ribosomal protein S20 -0.0281706
RPL26 ribosomal protein L26 -0.0276745
ANKRD12 ankyrin repeat domain 12 -0.0276334
KLC1 kinesin light chain 1 -0.0267334
OXR1 oxidation resistance 1 -0.0266728
NCEH1 neutral cholesterol ester hydrolase 1 -0.0265679
MATR3 matrin 3 -0.0262996
ATP5F1B ATP synthase F1 subunit beta -0.0262244
ASTN2 astrotactin 2 -0.0260469
EEF2 eukaryotic translation elongation factor 2 -0.0258062
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0255246
MMP12 matrix metallopeptidase 12 -0.0251794
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.025151
KLHL24 kelch-like family member 24 -0.024661
KPNB1 karyopherin (importin) beta 1 -0.0245806
S100A9 S100 calcium binding protein A9 -0.0232916
MAP4 microtubule-associated protein 4 -0.0231691
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0231608
RPL39 ribosomal protein L39 -0.0229256
SBF2 SET binding factor 2 -0.0227195
FBXL20 F-box and leucine-rich repeat protein 20 -0.0225677
CDK6 cyclin-dependent kinase 6 -0.0224632
TMEM123 transmembrane protein 123 -0.0220346
NHSL1 NHS-like 1 -0.0220045
SLC38A1 solute carrier family 38, member 1 -0.0218657
TGM2 transglutaminase 2 -0.0216757
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0216121
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0215939
TMEM41B transmembrane protein 41B -0.0212219
RPS26 ribosomal protein S26 -0.0209806
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0209761
RPS27A ribosomal protein S27a -0.0209359
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0206954
EPHA5 EPH receptor A5 -0.0205876
EDN1 endothelin 1 -0.0203605
RPL32 ribosomal protein L32 -0.0203044
RPS10 ribosomal protein S10 -0.0201886
GCG glucagon -0.0198998
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0198652
TENM3 teneurin transmembrane protein 3 -0.0197348
RPL31 ribosomal protein L31 -0.0196596