Gemfibrozil_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Gemfibrozil_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.204228
LSAMP limbic system-associated membrane protein 0.111851
EXT1 exostosin glycosyltransferase 1 0.0939895
PTPRD protein tyrosine phosphatase, receptor type, D 0.08972
PLAT plasminogen activator, tissue 0.0892785
AKAP12 A kinase (PRKA) anchor protein 12 0.087887
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0736104
BPTF bromodomain PHD finger transcription factor 0.073083
TLE4 transducin-like enhancer of split 4 0.0729567
VMP1 vacuole membrane protein 1 0.0718361
ZSWIM6 zinc finger, SWIM-type containing 6 0.0702269
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0594951
NPAS2 neuronal PAS domain protein 2 0.0582548
FMN1 formin 1 0.0528775
ACTG1 actin gamma 1 0.0519091
SYT1 synaptotagmin I 0.0517669
SLC38A2 solute carrier family 38, member 2 0.0479424
SEPTIN9 septin 9 0.0471385
DIAPH2 diaphanous-related formin 2 0.0460388
BCAS3 breast carcinoma amplified sequence 3 0.0434436
TPM1 tropomyosin 1 (alpha) 0.0412447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0401972
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0401155
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0397698
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0393401
MACF1 microtubule-actin crosslinking factor 1 0.0387657
ATXN1 ataxin 1 0.0381555
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0381107
ZBTB20 zinc finger and BTB domain containing 20 0.0380794
MYO1E myosin IE 0.037618
THBS1 thrombospondin 1 0.0375952
MCL1 myeloid cell leukemia 1 0.0371307
MYH9 myosin, heavy chain 9, non-muscle 0.0347083
RAD51B RAD51 paralog B 0.0341481
TPT1 tumor protein, translationally-controlled 1 0.0338708
EGR1 early growth response 1 0.0338546
ASPH aspartate beta-hydroxylase 0.0337658
INTS6 integrator complex subunit 6 0.0332253
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0329663
TIMP3 TIMP metallopeptidase inhibitor 3 0.0327019
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0321198
SENP6 SUMO1/sentrin specific peptidase 6 0.0317972
SETBP1 SET binding protein 1 0.0308581
PTPRK protein tyrosine phosphatase, receptor type, K 0.0307251
MBNL1 muscleblind-like splicing regulator 1 0.0307245
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301958
SVIL supervillin 0.0296523
THSD4 thrombospondin, type I, domain containing 4 0.0292587
CTNND1 catenin (cadherin-associated protein), delta 1 0.0284949
FLT1 fms-related tyrosine kinase 1 0.0281514
ZNF638 zinc finger protein 638 0.0277991
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0277404
RPS3 ribosomal protein S3 0.0276308
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0275608
PTPRM protein tyrosine phosphatase, receptor type, M 0.027449
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0272386
NFE2L1 nuclear factor, erythroid 2-like 1 0.0271145
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.026858
YAP1 Yes-associated protein 1 0.0268333
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.026583
SAMD4A sterile alpha motif domain containing 4A 0.0264492
TTC3 tetratricopeptide repeat domain 3 0.0264124
PLPP1 phospholipid phosphatase 1 0.0262167
FERMT2 fermitin family member 2 0.0262054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0261998
ENO1 enolase 1, (alpha) 0.0261652
PDLIM5 PDZ and LIM domain 5 0.025976
FNDC3A fibronectin type III domain containing 3A 0.025896
ACTN4 actinin, alpha 4 0.025664
FAM107B family with sequence similarity 107, member B 0.0256503
FNIP1 folliculin interacting protein 1 0.0255023
MEF2A myocyte enhancer factor 2A 0.0253066
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0253053
CUX1 cut-like homeobox 1 0.0252383
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0252372
SLIT2 slit homolog 2 (Drosophila) 0.0251935
ANO6 anoctamin 6 0.024886
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0248043
RPS17 ribosomal protein S17 0.024614
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0245319
CADM1 cell adhesion molecule 1 0.0245127
SNX14 sorting nexin 14 0.0244345
FNDC3B fibronectin type III domain containing 3B 0.0241044
SP100 SP100 nuclear antigen 0.0240557
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0240398
TAS2R14 taste receptor, type 2, member 14 0.0238013
VEGFA vascular endothelial growth factor A 0.0236677
ZC3H11A zinc finger CCCH-type containing 11A 0.0236567
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0236254
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0234844
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0234752
SET SET nuclear proto-oncogene 0.0231674
WWTR1 WW domain containing transcription regulator 1 0.0231314
GLS2 glutaminase 2 (liver, mitochondrial) 0.0230921
DOCK5 dedicator of cytokinesis 5 0.0230567
EXOC4 exocyst complex component 4 0.0230352
TPR translocated promoter region, nuclear basket protein 0.0230238
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0229419
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0228676
CDH13 cadherin 13 0.0227998

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.191342
IGF2 insulin-like growth factor 2 -0.147177
LPIN1 lipin 1 -0.0560741
RPS6 ribosomal protein S6 -0.0443946
NCAM2 neural cell adhesion molecule 2 -0.0435691
COL1A1 collagen, type I, alpha 1 -0.0406232
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0388153
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0362805
GLI3 GLI family zinc finger 3 -0.0323702
TRIB2 tribbles pseudokinase 2 -0.0303512
TMSB10 thymosin beta 10 -0.0263622
AOPEP aminopeptidase O (putative) -0.0245901
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0236616
DPH6 diphthamine biosynthesis 6 -0.0230893
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0225795
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0222525
TULP4 tubby like protein 4 -0.0222367
RPLP1 ribosomal protein, large, P1 -0.0222159
ANGPT1 angiopoietin 1 -0.0221637
LCORL ligand dependent nuclear receptor corepressor-like -0.0221144
LRP1B low density lipoprotein receptor-related protein 1B -0.0212251
RPS19 ribosomal protein S19 -0.0209724
NPEPPS aminopeptidase puromycin sensitive -0.0207866
NEK7 NIMA-related kinase 7 -0.0206043
GOLGA4 golgin A4 -0.0196609
LMAN1 lectin, mannose-binding, 1 -0.0195682
RPL23 ribosomal protein L23 -0.0194668
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0193377
PTMA prothymosin, alpha -0.0191388
COL6A1 collagen, type VI, alpha 1 -0.0191065
RPS5 ribosomal protein S5 -0.0191057
TNPO3 transportin 3 -0.0189435
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0187962
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0186984
RAD21 RAD21 homolog (S. pombe) -0.0185959
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0185826
GARS1 glycyl-tRNA synthetase 1 -0.0183567
CEP95 centrosomal protein 95kDa -0.0181201
UBE2K ubiquitin-conjugating enzyme E2K -0.0181074
RNF145 ring finger protein 145 -0.0178821
LMNA lamin A/C -0.0177472
TENT5A terminal nucleotidyltransferase 5A -0.0173683
RBL2 retinoblastoma-like 2 -0.0173515
GATA3 GATA binding protein 3 -0.0171921
ADAR adenosine deaminase, RNA-specific -0.0171512
MEIS2 Meis homeobox 2 -0.0171253
EDNRA endothelin receptor type A -0.0170813
SEC63 SEC63 homolog (S. cerevisiae) -0.0167865
USP3 ubiquitin specific peptidase 3 -0.0166919
FBXL20 F-box and leucine-rich repeat protein 20 -0.0164709
ARF1 ADP-ribosylation factor 1 -0.0164528
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0164459
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0162107
FOXK2 forkhead box K2 -0.0161665
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0161074
DTNA dystrobrevin, alpha -0.0160057
CASC3 cancer susceptibility candidate 3 -0.0160045
OGA O-GlcNAcase -0.0159882
SOS1 son of sevenless homolog 1 (Drosophila) -0.0159547
DACH2 dachshund family transcription factor 2 -0.0158899
RPLP0 ribosomal protein, large, P0 -0.0157847
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0157242
RPS29 ribosomal protein S29 -0.0156308
MARCHF6 membrane associated ring-CH-type finger 6 -0.0156124
PDS5B PDS5 cohesin associated factor B -0.015528
XPO1 exportin 1 -0.0155007
CD36 CD36 molecule (thrombospondin receptor) -0.0153888
CDC27 cell division cycle 27 -0.0152496
ANXA2 annexin A2 -0.0150771
PHIP pleckstrin homology domain interacting protein -0.0150692
GPHN gephyrin -0.0150217
CCDC50 coiled-coil domain containing 50 -0.0148277
MARCHF7 membrane associated ring-CH-type finger 7 -0.0148221
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0147583
RPS14 ribosomal protein S14 -0.0146238
RPL8 ribosomal protein L8 -0.0145559
IGFBP3 insulin-like growth factor binding protein 3 -0.0144401
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0144252
NRG1 neuregulin 1 -0.0143787
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0143637
RLF rearranged L-myc fusion -0.0142758
CADM2 cell adhesion molecule 2 -0.0142298
CENPF centromere protein F, 350/400kDa -0.0141493
HMGB1 high mobility group box 1 -0.0140093
MAP4 microtubule-associated protein 4 -0.0139287
ZMAT3 zinc finger, matrin-type 3 -0.0138281
PHKB phosphorylase kinase, beta -0.0137891
MAP1B microtubule-associated protein 1B -0.013748
KMT2C lysine (K)-specific methyltransferase 2C -0.0137376
TUBB tubulin, beta class I -0.013736
TOB1 transducer of ERBB2, 1 -0.0136208
INTS2 integrator complex subunit 2 -0.0136187
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0135931
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.01359
HOOK2 hook microtubule-tethering protein 2 -0.0134776
SNU13 small nuclear ribonucleoprotein 13 -0.013419
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0134152
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0133494
GNAS GNAS complex locus -0.0132583
MORF4L1 mortality factor 4 like 1 -0.0132036