Gemfibrozil_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.166349
TRIO trio Rho guanine nucleotide exchange factor 0.139237
VEGFA vascular endothelial growth factor A 0.128591
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.1204
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.11478
COL6A3 collagen, type VI, alpha 3 0.107072
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0925907
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0884965
FNDC3B fibronectin type III domain containing 3B 0.0863512
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0808726
CADM1 cell adhesion molecule 1 0.0803765
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0774209
NALF1 NALCN channel auxiliary factor 1 0.0673017
EGFR epidermal growth factor receptor 0.066107
JARID2 jumonji, AT rich interactive domain 2 0.06131
ATXN1 ataxin 1 0.0606719
ASPH aspartate beta-hydroxylase 0.0583864
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0582708
EXT1 exostosin glycosyltransferase 1 0.0547738
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0541227
NDRG1 N-myc downstream regulated 1 0.0530648
COL5A1 collagen, type V, alpha 1 0.052301
TTC3 tetratricopeptide repeat domain 3 0.0504152
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0502321
GOLGB1 golgin B1 0.0500979
ZSWIM6 zinc finger, SWIM-type containing 6 0.0497991
HDAC9 histone deacetylase 9 0.04623
MACF1 microtubule-actin crosslinking factor 1 0.044723
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0440758
PRELID2 PRELI domain containing 2 0.0436708
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0424031
PSD3 pleckstrin and Sec7 domain containing 3 0.0418433
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.039537
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0382008
SQSTM1 sequestosome 1 0.0378026
SLC38A2 solute carrier family 38, member 2 0.0370287
DST dystonin 0.0364897
FNIP1 folliculin interacting protein 1 0.0358091
VCL vinculin 0.0348565
RUNX1 runt-related transcription factor 1 0.0340957
NAV1 neuron navigator 1 0.0340746
ZBTB20 zinc finger and BTB domain containing 20 0.0333704
FMNL2 formin-like 2 0.0333579
ANKRD11 ankyrin repeat domain 11 0.0332082
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0330305
PDE10A phosphodiesterase 10A 0.0328742
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0326569
IARS1 isoleucyl-tRNA synthetase 1 0.0322493
NAV2 neuron navigator 2 0.0314655
PICALM phosphatidylinositol binding clathrin assembly protein 0.0309579
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0306144
DPYSL2 dihydropyrimidinase-like 2 0.0304098
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0303568
PDIA5 protein disulfide isomerase family A, member 5 0.0303102
COL7A1 collagen, type VII, alpha 1 0.0302206
FBN1 fibrillin 1 0.0297052
INTS6 integrator complex subunit 6 0.0296407
RND3 Rho family GTPase 3 0.029138
LPP LIM domain containing preferred translocation partner in lipoma 0.0284045
MYO10 myosin X 0.027024
PTPRG protein tyrosine phosphatase, receptor type, G 0.0270109
PTPRM protein tyrosine phosphatase, receptor type, M 0.0269393
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.026791
HIPK2 homeodomain interacting protein kinase 2 0.0261439
EFNA5 ephrin-A5 0.0261143
NEK10 NIMA-related kinase 10 0.0258985
GRB10 growth factor receptor-bound protein 10 0.0257111
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0256454
ANXA1 annexin A1 0.0255778
HYOU1 hypoxia up-regulated 1 0.0255204
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0252525
CAMTA1 calmodulin binding transcription activator 1 0.0249745
ZBTB38 zinc finger and BTB domain containing 38 0.0247587
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0247071
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0241826
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0240846
SDC2 syndecan 2 0.0239701
OSBPL8 oxysterol binding protein-like 8 0.0236306
CDK13 cyclin-dependent kinase 13 0.0236157
USP34 ubiquitin specific peptidase 34 0.023452
DOCK7 dedicator of cytokinesis 7 0.0233776
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0231555
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0231389
CUX1 cut-like homeobox 1 0.0230955
ANO10 anoctamin 10 0.0228313
BRD2 bromodomain containing 2 0.0224994
DSPP dentin sialophosphoprotein 0.0224517
SEC31A SEC31 homolog A (S. cerevisiae) 0.022436
DOCK5 dedicator of cytokinesis 5 0.0224141
LTBP1 latent transforming growth factor beta binding protein 1 0.0221338
ANO6 anoctamin 6 0.0217212
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0215989
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0215781
EXOC4 exocyst complex component 4 0.0215068
MTDH metadherin 0.0214814
PTK2 protein tyrosine kinase 2 0.0213439
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0213089
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0212944
NPAS2 neuronal PAS domain protein 2 0.0211813
CMIP c-Maf inducing protein 0.0210949

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.273978
FN1 fibronectin 1 -0.240259
VIM vimentin -0.213371
MT2A metallothionein 2A -0.17151
COL1A1 collagen, type I, alpha 1 -0.152936
TMSB10 thymosin beta 10 -0.131383
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0984685
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0766464
IGFBP3 insulin-like growth factor binding protein 3 -0.0763364
LGALS1 lectin, galactoside-binding, soluble, 1 -0.061699
PTMA prothymosin, alpha -0.0606679
FTL ferritin, light polypeptide -0.0572155
TM4SF1 transmembrane 4 L six family member 1 -0.0512716
COL1A2 collagen, type I, alpha 2 -0.0507142
S100A9 S100 calcium binding protein A9 -0.0421842
HLA-B major histocompatibility complex, class I, B -0.040902
S100A6 S100 calcium binding protein A6 -0.0399246
RPL35A ribosomal protein L35a -0.0391315
EIF1 eukaryotic translation initiation factor 1 -0.0385665
DPYSL3 dihydropyrimidinase-like 3 -0.0383274
B2M beta-2-microglobulin -0.0377346
STC1 stanniocalcin 1 -0.0372219
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0372076
IGFBP7 insulin-like growth factor binding protein 7 -0.0354952
LOC112694756 uncharaterized LOC112694756 -0.0340893
MT1X metallothionein 1X -0.0328075
RPL23 ribosomal protein L23 -0.0323506
RPS19 ribosomal protein S19 -0.0318579
DPYD dihydropyrimidine dehydrogenase -0.0308591
RPS6 ribosomal protein S6 -0.0307048
ANXA2 annexin A2 -0.0302787
RPL36 ribosomal protein L36 -0.029903
RPS8 ribosomal protein S8 -0.029213
ICAM1 intercellular adhesion molecule 1 -0.0290128
RPL19 ribosomal protein L19 -0.0279978
IFI6 interferon, alpha-inducible protein 6 -0.027839
UBC ubiquitin C -0.0258729
POSTN periostin, osteoblast specific factor -0.02521
RPLP1 ribosomal protein, large, P1 -0.0248925
FTH1 ferritin, heavy polypeptide 1 -0.0248224
RPL11 ribosomal protein L11 -0.0243855
LOXL2 lysyl oxidase-like 2 -0.0241851
RPS21 ribosomal protein S21 -0.0241702
RPL12 ribosomal protein L12 -0.0237624
RPS13 ribosomal protein S13 -0.0230225
ANTXR2 anthrax toxin receptor 2 -0.022338
SRGN serglycin -0.0221345
PFN1 profilin 1 -0.0219031
RPLP2 ribosomal protein, large, P2 -0.0218143
RAD21 RAD21 homolog (S. pombe) -0.02181
CD44 CD44 molecule (Indian blood group) -0.0216944
IL6 interleukin 6 -0.0216037
IFITM3 interferon induced transmembrane protein 3 -0.0214763
TMSB4X thymosin beta 4, X-linked -0.0213172
RPL34 ribosomal protein L34 -0.0213169
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0212706
TPM4 tropomyosin 4 -0.021099
ECE1 endothelin converting enzyme 1 -0.0208711
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0205383
RPS14 ribosomal protein S14 -0.0204307
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0201976
RPS27A ribosomal protein S27a -0.0201605
RPL26 ribosomal protein L26 -0.0199117
LOX lysyl oxidase -0.0196614
RPS5 ribosomal protein S5 -0.0189939
RPS25 ribosomal protein S25 -0.0187959
ISG15 ISG15 ubiquitin-like modifier -0.0184455
F3 coagulation factor III (thromboplastin, tissue factor) -0.0181249
RPL32 ribosomal protein L32 -0.018085
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0180364
OSMR oncostatin M receptor -0.017967
RPS23 ribosomal protein S23 -0.0177933
TPM2 tropomyosin 2 (beta) -0.017345
RPL28 ribosomal protein L28 -0.0173143
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0171921
YBX1 Y box binding protein 1 -0.0170351
RPL8 ribosomal protein L8 -0.0169405
TPI1 triosephosphate isomerase 1 -0.0167879
CTSB cathepsin B -0.0167249
CAVIN1 caveolae associated protein 1 -0.016704
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0165603
S100A10 S100 calcium binding protein A10 -0.0160356
SERF2 small EDRK-rich factor 2 -0.0159665
BSG basigin (Ok blood group) -0.0156174
RPS11 ribosomal protein S11 -0.0155087
RPS27 ribosomal protein S27 -0.0154546
HLA-A major histocompatibility complex, class I, A -0.015326
RPL36A ribosomal protein L36a -0.0151758
RPS16 ribosomal protein S16 -0.0151192
RPL5 ribosomal protein L5 -0.0151051
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0150011
ENO1 enolase 1, (alpha) -0.0148474
CD63 CD63 molecule -0.0148134
PLAUR plasminogen activator, urokinase receptor -0.0148022
EGR1 early growth response 1 -0.0147587
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0146538
TNIP1 TNFAIP3 interacting protein 1 -0.0145899
CD99 CD99 molecule -0.0145898
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0143923
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.014383