Gemfibrozil_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.148515
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.092812
LDHA lactate dehydrogenase A 0.087248
AKAP13 A kinase (PRKA) anchor protein 13 0.0831748
TRIO trio Rho guanine nucleotide exchange factor 0.079693
STC1 stanniocalcin 1 0.0779607
DST dystonin 0.0736037
PTK2 protein tyrosine kinase 2 0.0733798
FNDC3B fibronectin type III domain containing 3B 0.0715504
MEF2A myocyte enhancer factor 2A 0.0659165
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0630182
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0619585
KLF5 Kruppel-like factor 5 (intestinal) 0.0616068
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0593414
MBNL1 muscleblind-like splicing regulator 1 0.0588371
TSC22D1 TSC22 domain family, member 1 0.0587538
ITGA6 integrin, alpha 6 0.0564024
SLC38A2 solute carrier family 38, member 2 0.0556125
RASAL2 RAS protein activator like 2 0.0538426
MYOF myoferlin 0.053171
ARHGAP21 Rho GTPase activating protein 21 0.0531531
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0525685
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0516602
DOCK5 dedicator of cytokinesis 5 0.0500138
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0497585
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0491184
PICALM phosphatidylinositol binding clathrin assembly protein 0.0490723
ASPH aspartate beta-hydroxylase 0.0482795
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0478369
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0464922
CTTN cortactin 0.0462372
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0453352
RICTOR RPTOR independent companion of MTOR, complex 2 0.0443753
KTN1 kinectin 1 (kinesin receptor) 0.041584
FRMD6 FERM domain containing 6 0.0415441
AOPEP aminopeptidase O (putative) 0.0412724
EGFR epidermal growth factor receptor 0.0402223
CSNK1A1 casein kinase 1, alpha 1 0.0401404
APP amyloid beta (A4) precursor protein 0.0399679
CD44 CD44 molecule (Indian blood group) 0.0396549
NAP1L1 nucleosome assembly protein 1-like 1 0.039654
ITCH itchy E3 ubiquitin protein ligase 0.0396285
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0395338
FAM107B family with sequence similarity 107, member B 0.039407
BCAR3 breast cancer anti-estrogen resistance 3 0.0393749
SEPTIN7 septin 7 0.0388174
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0384646
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0375324
UBC ubiquitin C 0.037385
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0363182
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0363181
APLP2 amyloid beta (A4) precursor-like protein 2 0.036008
CANX calnexin 0.0357687
DSCAM Down syndrome cell adhesion molecule 0.0351416
PLS3 plastin 3 0.0350941
RTN4 reticulon 4 0.0348173
RAB10 RAB10, member RAS oncogene family 0.0347721
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0346228
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0344784
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0344396
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0344231
RNF145 ring finger protein 145 0.0343331
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0342658
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342169
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0339153
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0336694
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335493
FMNL2 formin-like 2 0.0334369
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0331301
SEC31A SEC31 homolog A (S. cerevisiae) 0.0330967
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0330235
ZFAND3 zinc finger, AN1-type domain 3 0.0330179
CAV1 caveolin 1, caveolae protein, 22kDa 0.0327084
CDC73 cell division cycle 73 0.0323979
OSBPL3 oxysterol binding protein-like 3 0.0320339
LNPEP leucyl/cystinyl aminopeptidase 0.0318521
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.031442
MED13L mediator complex subunit 13-like 0.0310043
ANKRD17 ankyrin repeat domain 17 0.0309674
SQLE squalene epoxidase 0.0309569
PARD3 par-3 family cell polarity regulator 0.0305265
OXSR1 oxidative stress responsive 1 0.0304311
ZNF292 zinc finger protein 292 0.0303958
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0301075
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0300947
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0297926
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0297802
COPA coatomer protein complex, subunit alpha 0.0296576
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0296465
OSBPL8 oxysterol binding protein-like 8 0.02948
PDIA6 protein disulfide isomerase family A, member 6 0.0293894
ITGAV integrin, alpha V 0.0292833
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0291796
CEMIP cell migration inducing protein, hyaluronan binding 0.029062
ESYT2 extended synaptotagmin-like protein 2 0.0290325
BZW1 basic leucine zipper and W2 domains 1 0.0290264
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0288074
SLC35F3 solute carrier family 35, member F3 0.0287924
BARX2 BARX homeobox 2 0.0285091
ZSWIM6 zinc finger, SWIM-type containing 6 0.028498

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.2234
TMSB10 thymosin beta 10 -0.112758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100251
RPS21 ribosomal protein S21 -0.0982276
NDRG1 N-myc downstream regulated 1 -0.0956843
RPS6 ribosomal protein S6 -0.0939868
SULF1 sulfatase 1 -0.0930701
DPYD dihydropyrimidine dehydrogenase -0.0926956
MT2A metallothionein 2A -0.0787254
TMSB4X thymosin beta 4, X-linked -0.0764242
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0755571
IFITM1 interferon induced transmembrane protein 1 -0.0687372
IFITM3 interferon induced transmembrane protein 3 -0.063821
EGR1 early growth response 1 -0.0629518
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0612191
HLA-B major histocompatibility complex, class I, B -0.0605833
RPS19 ribosomal protein S19 -0.0579773
RPL34 ribosomal protein L34 -0.0564975
LOC112694756 uncharaterized LOC112694756 -0.0541303
RPLP1 ribosomal protein, large, P1 -0.0536884
RPS13 ribosomal protein S13 -0.0535225
RPLP2 ribosomal protein, large, P2 -0.0534561
RPL11 ribosomal protein L11 -0.0533993
S100A9 S100 calcium binding protein A9 -0.0523721
S100A10 S100 calcium binding protein A10 -0.0476122
SQSTM1 sequestosome 1 -0.0471519
RPS27 ribosomal protein S27 -0.0463337
RPL12 ribosomal protein L12 -0.0445215
OSMR oncostatin M receptor -0.0442398
MTSS1 metastasis suppressor 1 -0.0430718
RPL35A ribosomal protein L35a -0.0427269
LDLR low density lipoprotein receptor -0.0397802
LMNA lamin A/C -0.0394215
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.039206
S100A2 S100 calcium binding protein A2 -0.0389528
MECOM MDS1 and EVI1 complex locus -0.0388049
B2M beta-2-microglobulin -0.0376454
RPL19 ribosomal protein L19 -0.0376221
ACTN4 actinin, alpha 4 -0.0371094
RPL8 ribosomal protein L8 -0.0369493
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0367628
SOD2 superoxide dismutase 2, mitochondrial -0.0351972
RPL36 ribosomal protein L36 -0.0341492
IRF1 interferon regulatory factor 1 -0.0340626
RIN2 Ras and Rab interactor 2 -0.0333317
HM13 histocompatibility (minor) 13 -0.0327491
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0325649
WARS1 tryptophanyl-tRNA synthetase 1 -0.0324448
RPL5 ribosomal protein L5 -0.0316594
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0315924
ABI3BP ABI family, member 3 (NESH) binding protein -0.0314293
S100A4 S100 calcium binding protein A4 -0.031215
PRSS23 protease, serine, 23 -0.0308188
CLIC4 chloride intracellular channel 4 -0.03061
ZNFX1 zinc finger, NFX1-type containing 1 -0.0304102
TPM4 tropomyosin 4 -0.0302685
RPS14 ribosomal protein S14 -0.0302572
RPL23 ribosomal protein L23 -0.0299167
LAMA5 laminin, alpha 5 -0.0298978
RIGI RNA sensor RIG-I -0.0293395
RPS3 ribosomal protein S3 -0.028747
GUK1 guanylate kinase 1 -0.0286718
FLNA filamin A, alpha -0.0285156
RPS29 ribosomal protein S29 -0.028044
ANXA2 annexin A2 -0.0276763
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0275455
ADIRF adipogenesis regulatory factor -0.0273314
RPL28 ribosomal protein L28 -0.0270776
HLA-A major histocompatibility complex, class I, A -0.0269804
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0268861
CNRIP1 cannabinoid receptor interacting protein 1 -0.0267083
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0266574
RPS16 ribosomal protein S16 -0.0264281
RPL35 ribosomal protein L35 -0.0263434
RPL7 ribosomal protein L7 -0.02633
EMP1 epithelial membrane protein 1 -0.0263078
RPL39 ribosomal protein L39 -0.0261989
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0261387
RPL7A ribosomal protein L7a -0.0259904
RPS8 ribosomal protein S8 -0.0255403
RPL31 ribosomal protein L31 -0.0255229
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0252115
ITGB4 integrin, beta 4 -0.0250968
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0248316
FSCN1 fascin actin-bundling protein 1 -0.023998
ZMYND8 zinc finger, MYND-type containing 8 -0.0239424
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0238242
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0236921
THBD thrombomodulin -0.0236141
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0235906
RPS23 ribosomal protein S23 -0.0234565
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0233233
S100A6 S100 calcium binding protein A6 -0.0229693
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0228631
PTMA prothymosin, alpha -0.022828
RPL32 ribosomal protein L32 -0.0227057
IFIH1 interferon induced with helicase C domain 1 -0.02268
FAF1 Fas (TNFRSF6) associated factor 1 -0.0224327
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0224245
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0223802