Gemfibrozil_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.199988
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.195139
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.17161
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.106316
LMO7 LIM domain 7 0.104594
AREG amphiregulin 0.10411
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.07099
KLF5 Kruppel-like factor 5 (intestinal) 0.0699686
SLC38A2 solute carrier family 38, member 2 0.0666699
SOX9 SRY (sex determining region Y)-box 9 0.0648645
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0642054
CD46 CD46 molecule, complement regulatory protein 0.062647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0611963
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0605517
MACF1 microtubule-actin crosslinking factor 1 0.0601943
MED13 mediator complex subunit 13 0.0600967
EPS8 epidermal growth factor receptor pathway substrate 8 0.0598492
ITGA6 integrin, alpha 6 0.0570604
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0550457
ASPH aspartate beta-hydroxylase 0.0536074
LOC102724023 ES1 protein homolog, mitochondrial 0.0534857
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0528643
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0526005
CD44 CD44 molecule (Indian blood group) 0.0520541
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.051346
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0473852
PDIA4 protein disulfide isomerase family A, member 4 0.0472766
MYO1E myosin IE 0.0454265
RNF145 ring finger protein 145 0.044245
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0441313
CADPS Ca++-dependent secretion activator 0.0439495
ARHGAP26 Rho GTPase activating protein 26 0.0406847
TNS4 tensin 4 0.0394052
PELI1 pellino E3 ubiquitin protein ligase 1 0.0393856
PDZD8 PDZ domain containing 8 0.0393089
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0389398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0388355
CTNND1 catenin (cadherin-associated protein), delta 1 0.038803
CEMIP2 cell migration inducing hyaluronidase 2 0.0380935
VMP1 vacuole membrane protein 1 0.0375199
EXT1 exostosin glycosyltransferase 1 0.0373442
AKAP13 A kinase (PRKA) anchor protein 13 0.0372281
CEMIP cell migration inducing protein, hyaluronan binding 0.0371864
ECT2 epithelial cell transforming 2 0.0368703
RNF43 ring finger protein 43 0.0368589
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367469
CENPF centromere protein F, 350/400kDa 0.0363032
USP53 ubiquitin specific peptidase 53 0.0362323
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0356769
PTBP3 polypyrimidine tract binding protein 3 0.0353178
RBM39 RNA binding motif protein 39 0.0351928
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.035043
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0348199
RAB10 RAB10, member RAS oncogene family 0.0347643
NAP1L1 nucleosome assembly protein 1-like 1 0.0344662
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0332775
WAC WW domain containing adaptor with coiled-coil 0.0330833
UBE2H ubiquitin-conjugating enzyme E2H 0.0328861
SON SON DNA binding protein 0.0325668
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0310503
POF1B premature ovarian failure, 1B 0.0308782
CAB39 calcium binding protein 39 0.0306821
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0306451
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0305058
VCL vinculin 0.0303717
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0303386
RPLP0 ribosomal protein, large, P0 0.0302061
TRA2A transformer 2 alpha homolog (Drosophila) 0.0297945
NOSTRIN nitric oxide synthase trafficking 0.029628
MYO5B myosin VB 0.0296073
PDLIM5 PDZ and LIM domain 5 0.0295626
SMAD2 SMAD family member 2 0.029357
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.028967
LAMA4 laminin, alpha 4 0.028722
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0284781
PERP PERP, TP53 apoptosis effector 0.0279825
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0278713
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0273674
LRRC1 leucine rich repeat containing 1 0.0271824
NEBL nebulette 0.027157
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0270926
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0270676
BCLAF1 BCL2-associated transcription factor 1 0.0267633
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0264686
IER3 immediate early response 3 0.0264302
SRRM1 serine/arginine repetitive matrix 1 0.026245
CCNL1 cyclin L1 0.0260822
CSNK1A1 casein kinase 1, alpha 1 0.026009
CHD1 chromodomain helicase DNA binding protein 1 0.025898
ANKRD17 ankyrin repeat domain 17 0.0258767
SPAG9 sperm associated antigen 9 0.0257769
THOC2 THO complex 2 0.0255798
CALR calreticulin 0.0253704
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.025232
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0252183
MYO10 myosin X 0.0246464
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0246145
UBA6 ubiquitin-like modifier activating enzyme 6 0.0246027
EREG epiregulin 0.0244097
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0243982

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.157834
NPSR1 neuropeptide S receptor 1 -0.115404
TMSB10 thymosin beta 10 -0.114274
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.108634
AHNAK AHNAK nucleoprotein -0.104261
PTMA prothymosin, alpha -0.0836401
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0798993
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0780561
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0775805
RPL35A ribosomal protein L35a -0.0772723
PIGR polymeric immunoglobulin receptor -0.0721723
RPL31 ribosomal protein L31 -0.0720623
LOC112694756 uncharaterized LOC112694756 -0.0687717
BACE2 beta-site APP-cleaving enzyme 2 -0.0625061
FTL ferritin, light polypeptide -0.0612742
RPS8 ribosomal protein S8 -0.0583074
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0571901
ISG15 ISG15 ubiquitin-like modifier -0.0509705
TPT1 tumor protein, translationally-controlled 1 -0.0500456
ESYT2 extended synaptotagmin-like protein 2 -0.0494619
EIF1 eukaryotic translation initiation factor 1 -0.0488595
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0470836
RPS13 ribosomal protein S13 -0.0458463
RPLP2 ribosomal protein, large, P2 -0.0457533
TMSB4X thymosin beta 4, X-linked -0.0441442
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0440147
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0437037
RPL19 ribosomal protein L19 -0.0434054
ONECUT3 one cut homeobox 3 -0.0431537
ANXA2 annexin A2 -0.0431382
RPL3 ribosomal protein L3 -0.0424204
RPL34 ribosomal protein L34 -0.0418113
CCSER1 coiled-coil serine-rich protein 1 -0.041448
RPS29 ribosomal protein S29 -0.0409723
HSPA8 heat shock 70kDa protein 8 -0.0397028
RPS19 ribosomal protein S19 -0.0396814
RPS23 ribosomal protein S23 -0.039609
NFIA nuclear factor I/A -0.0394666
RPLP1 ribosomal protein, large, P1 -0.0392496
KRT18 keratin 18, type I -0.038761
RPL38 ribosomal protein L38 -0.0385876
RPL13A ribosomal protein L13a -0.0382244
RPS27 ribosomal protein S27 -0.0381288
GMDS GDP-mannose 4,6-dehydratase -0.0380747
PKM pyruvate kinase, muscle -0.0379423
GREB1L growth regulation by estrogen in breast cancer-like -0.0375718
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0372738
RPL7A ribosomal protein L7a -0.0372722
TFF1 trefoil factor 1 -0.0365451
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0365293
RIN2 Ras and Rab interactor 2 -0.0354937
KDM4B lysine (K)-specific demethylase 4B -0.0352608
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0347351
ITGB4 integrin, beta 4 -0.0341071
ARHGAP6 Rho GTPase activating protein 6 -0.0340543
GOLGA4 golgin A4 -0.0329401
RPL4 ribosomal protein L4 -0.0328891
S100A6 S100 calcium binding protein A6 -0.0328089
PATJ PATJ crumbs cell polarity complex component -0.0327592
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0319103
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0318683
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0317234
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0312588
RPS25 ribosomal protein S25 -0.0311591
EZR ezrin -0.0310299
FAM13A family with sequence similarity 13, member A -0.0310189
RPL36 ribosomal protein L36 -0.0309945
RPS16 ribosomal protein S16 -0.0304672
RPL37 ribosomal protein L37 -0.0304154
RPS20 ribosomal protein S20 -0.0303491
TAS2R14 taste receptor, type 2, member 14 -0.0300437
SLC35F3 solute carrier family 35, member F3 -0.0295339
NUPR1 nuclear protein, transcriptional regulator, 1 -0.0294661
MAML2 mastermind-like 2 (Drosophila) -0.0292484
KRT8 keratin 8, type II -0.0290387
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0285779
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0284618
RPL36A ribosomal protein L36a -0.0283964
LMNA lamin A/C -0.0281051
RPL11 ribosomal protein L11 -0.0280428
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0278772
RPS17 ribosomal protein S17 -0.0278343
EIF4B eukaryotic translation initiation factor 4B -0.0276596
RPS21 ribosomal protein S21 -0.0272649
RPL28 ribosomal protein L28 -0.0272618
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0269157
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0268855
RPL23 ribosomal protein L23 -0.0268172
GRB10 growth factor receptor-bound protein 10 -0.0264389
SMYD3 SET and MYND domain containing 3 -0.0262949
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0262897
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0262888
NALF1 NALCN channel auxiliary factor 1 -0.0262448
KPNB1 karyopherin (importin) beta 1 -0.0262348
TPM4 tropomyosin 4 -0.0261591
EMP1 epithelial membrane protein 1 -0.0259398
GTF2IRD1 GTF2I repeat domain containing 1 -0.0258602
RPL26 ribosomal protein L26 -0.0258585
PARD3B par-3 family cell polarity regulator beta -0.0256672
COBL cordon-bleu WH2 repeat protein -0.0253937