Gemfibrozil_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.126522
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.113334
HMGA2 high mobility group AT-hook 2 0.101125
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0808864
ZSWIM6 zinc finger, SWIM-type containing 6 0.0799795
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0719764
SDK1 sidekick cell adhesion molecule 1 0.0710603
AADAC arylacetamide deacetylase 0.0706654
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0703302
INTS6 integrator complex subunit 6 0.0675629
FNDC3B fibronectin type III domain containing 3B 0.0664841
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0658729
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0619327
ASPH aspartate beta-hydroxylase 0.0616243
NTN4 netrin 4 0.0562889
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0559869
TRIO trio Rho guanine nucleotide exchange factor 0.0547428
EXT1 exostosin glycosyltransferase 1 0.0539367
GLCCI1 glucocorticoid induced 1 0.0534498
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.052388
PDLIM5 PDZ and LIM domain 5 0.0516485
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0505642
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0489521
NAP1L1 nucleosome assembly protein 1-like 1 0.0488739
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0455304
WLS wntless Wnt ligand secretion mediator 0.0454704
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0449304
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0445982
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0437265
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0435987
COL7A1 collagen, type VII, alpha 1 0.0426302
TGFB1 transforming growth factor, beta 1 0.0422412
IFI44L interferon-induced protein 44-like 0.042057
PDGFA platelet-derived growth factor alpha polypeptide 0.0413638
ATXN1 ataxin 1 0.0407143
EPS8 epidermal growth factor receptor pathway substrate 8 0.0404803
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0398272
CDH13 cadherin 13 0.0393117
LDHA lactate dehydrogenase A 0.0382563
GLS2 glutaminase 2 (liver, mitochondrial) 0.0382314
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0381419
WAC WW domain containing adaptor with coiled-coil 0.0377307
PTK2 protein tyrosine kinase 2 0.0375917
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0370811
FBXO11 F-box protein 11 0.0359341
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.03566
NLK nemo-like kinase 0.0355972
HIPK2 homeodomain interacting protein kinase 2 0.0352426
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0351655
LOXL2 lysyl oxidase-like 2 0.0348345
APLP2 amyloid beta (A4) precursor-like protein 2 0.0344051
PCBP2 poly(rC) binding protein 2 0.0340572
CD44 CD44 molecule (Indian blood group) 0.0338615
SIK3 SIK family kinase 3 0.0336733
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0334617
MBNL1 muscleblind-like splicing regulator 1 0.0333652
MACF1 microtubule-actin crosslinking factor 1 0.0332105
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0331013
CTBP2 C-terminal binding protein 2 0.0325032
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0323811
RCOR1 REST corepressor 1 0.0319441
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0315268
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313054
SP100 SP100 nuclear antigen 0.031249
MAML3 mastermind-like 3 (Drosophila) 0.0311669
EFCAB13 EF-hand calcium binding domain 13 0.0305935
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0301245
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0293771
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.029326
NDRG1 N-myc downstream regulated 1 0.0291777
SOS1 son of sevenless homolog 1 (Drosophila) 0.0287834
SQSTM1 sequestosome 1 0.0286228
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0285186
PRKCA protein kinase C, alpha 0.028324
MYO10 myosin X 0.0281378
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280475
NAV1 neuron navigator 1 0.0272329
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0271101
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0267487
WWTR1 WW domain containing transcription regulator 1 0.0266688
MED13 mediator complex subunit 13 0.0264135
RAB7A RAB7A, member RAS oncogene family 0.0261575
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0261132
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0259262
LRMDA leucine rich melanocyte differentiation associated 0.0252922
VCL vinculin 0.0252894
RAB1A RAB1A, member RAS oncogene family 0.0249688
JARID2 jumonji, AT rich interactive domain 2 0.024968
ZEB1 zinc finger E-box binding homeobox 1 0.0249663
UBC ubiquitin C 0.0247212
PIAS2 protein inhibitor of activated STAT, 2 0.0246559
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.024633
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0244557
ANKRD28 ankyrin repeat domain 28 0.0243692
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0242936
PEAK1 pseudopodium-enriched atypical kinase 1 0.0240914
VEGFA vascular endothelial growth factor A 0.0240684
ALCAM activated leukocyte cell adhesion molecule 0.0237273
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0237035
NPTN neuroplastin 0.0231655

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.186271
TMSB10 thymosin beta 10 -0.118503
MT2A metallothionein 2A -0.101318
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0990882
OSMR oncostatin M receptor -0.086239
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0819475
GOLGA4 golgin A4 -0.077372
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0638531
ZMYND8 zinc finger, MYND-type containing 8 -0.0624275
NPC1 Niemann-Pick disease, type C1 -0.0602239
VIM vimentin -0.0560627
RPS19 ribosomal protein S19 -0.0511337
RAB27B RAB27B, member RAS oncogene family -0.0506994
PDE4D phosphodiesterase 4D, cAMP-specific -0.0493602
IGFBP3 insulin-like growth factor binding protein 3 -0.0482579
EIF1 eukaryotic translation initiation factor 1 -0.0464418
GCC2 GRIP and coiled-coil domain containing 2 -0.042474
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0393788
CDCP1 CUB domain containing protein 1 -0.0387724
RPL35A ribosomal protein L35a -0.0387655
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0354024
AKAP9 A kinase (PRKA) anchor protein 9 -0.0353395
RPS6 ribosomal protein S6 -0.0349439
RPL36 ribosomal protein L36 -0.0347732
ZEB2 zinc finger E-box binding homeobox 2 -0.0336081
BASP1 brain abundant, membrane attached signal protein 1 -0.0328855
LRRC49 leucine rich repeat containing 49 -0.0328279
MYO9A myosin IXA -0.0323321
ETV6 ets variant 6 -0.0311936
BMAL2 basic helix-loop-helix ARNT like 2 -0.0310804
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0306637
RNF149 ring finger protein 149 -0.0304655
ZBTB20 zinc finger and BTB domain containing 20 -0.0299274
RPLP1 ribosomal protein, large, P1 -0.0298191
MON2 MON2 homolog (S. cerevisiae) -0.0294743
RPL34 ribosomal protein L34 -0.0294469
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0293797
USP34 ubiquitin specific peptidase 34 -0.028976
ADAM28 ADAM metallopeptidase domain 28 -0.0288117
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0282044
YEATS2 YEATS domain containing 2 -0.0278436
MBD5 methyl-CpG binding domain protein 5 -0.0275331
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0274488
FBXL13 F-box and leucine-rich repeat protein 13 -0.0271829
DPYSL3 dihydropyrimidinase-like 3 -0.027078
PTPRR protein tyrosine phosphatase, receptor type, R -0.0269602
RPS13 ribosomal protein S13 -0.0267416
SLC38A1 solute carrier family 38, member 1 -0.0263965
RPLP2 ribosomal protein, large, P2 -0.0262173
RPL32 ribosomal protein L32 -0.025992
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -0.0255516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0255302
KPNB1 karyopherin (importin) beta 1 -0.025526
RPS21 ribosomal protein S21 -0.0254762
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0252614
CANX calnexin -0.0246582
C15ORF48 chromosome 15 open reading frame 48 -0.0246175
EGFR epidermal growth factor receptor -0.024575
LMAN1 lectin, mannose-binding, 1 -0.0244324
COL12A1 collagen, type XII, alpha 1 -0.0240167
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0238448
RTN4 reticulon 4 -0.0237279
HDLBP high density lipoprotein binding protein -0.0235621
CFDP1 craniofacial development protein 1 -0.0234993
PID1 phosphotyrosine interaction domain containing 1 -0.0234608
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0233901
LRRC8C leucine rich repeat containing 8 family, member C -0.0232729
BABAM2 BRISC and BRCA1 A complex member 2 -0.0232523
ANAPC5 anaphase promoting complex subunit 5 -0.0230368
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0229358
PTGIS prostaglandin I2 (prostacyclin) synthase -0.022783
ZC3H12C zinc finger CCCH-type containing 12C -0.0225981
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0224465
NKTR natural killer cell triggering receptor -0.0223929
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0220513
RPL23 ribosomal protein L23 -0.0220366
FRMD4A FERM domain containing 4A -0.0217965
AAK1 AP2 associated kinase 1 -0.0214352
ATXN10 ataxin 10 -0.021353
PRRC2C proline-rich coiled-coil 2C -0.0212752
UBXN4 UBX domain protein 4 -0.0212522
YME1L1 YME1-like 1 ATPase -0.0212511
RNF24 ring finger protein 24 -0.0212316
NRP1 neuropilin 1 -0.0212072
RPS29 ribosomal protein S29 -0.0209484
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0206644
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0205483
FNBP4 formin binding protein 4 -0.0205381
EEA1 early endosome antigen 1 -0.0204822
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0202374
RPL12 ribosomal protein L12 -0.0202355
ELP2 elongator acetyltransferase complex subunit 2 -0.0200393
SBF2 SET binding factor 2 -0.0199479
PTMA prothymosin, alpha -0.0198629
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0194673
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0194131
NLRP1 NLR family, pyrin domain containing 1 -0.0192607
ZFR zinc finger RNA binding protein -0.0192571
DENND4A DENN/MADD domain containing 4A -0.0189459
CAB39 calcium binding protein 39 -0.018896