Gemfibrozil_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0902868
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0886424
ERRFI1 ERBB receptor feedback inhibitor 1 0.0824737
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0734629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0672177
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0639326
YBX3 Y box binding protein 3 0.0557164
RAD51B RAD51 paralog B 0.0551031
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0487081
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0481532
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0475214
ZNF638 zinc finger protein 638 0.0457513
RBM39 RNA binding motif protein 39 0.0448822
CANX calnexin 0.0429168
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0424908
AFF3 AF4/FMR2 family, member 3 0.0406253
ZCCHC7 zinc finger, CCHC domain containing 7 0.040418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0403874
PRELID2 PRELI domain containing 2 0.0388864
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.038859
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0387303
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0380547
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0369731
NF1 neurofibromin 1 0.0368496
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.036828
COPA coatomer protein complex, subunit alpha 0.0362908
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0341921
ANKRD36 ankyrin repeat domain 36 0.034036
STK4 serine/threonine kinase 4 0.032885
MCL1 myeloid cell leukemia 1 0.0327839
PRKCE protein kinase C, epsilon 0.0327225
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0326445
GOLGB1 golgin B1 0.0322514
NIPBL Nipped-B homolog (Drosophila) 0.0320438
RAB1A RAB1A, member RAS oncogene family 0.0320363
INTS6 integrator complex subunit 6 0.0320152
FMNL2 formin-like 2 0.0301963
OGA O-GlcNAcase 0.0300789
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0299958
CSNK1A1 casein kinase 1, alpha 1 0.0295061
BRD2 bromodomain containing 2 0.029486
LMAN1 lectin, mannose-binding, 1 0.0294096
TLN1 talin 1 0.0288607
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0287693
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.028668
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0282966
PTK2 protein tyrosine kinase 2 0.027745
KDM3A lysine (K)-specific demethylase 3A 0.0277079
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0275778
TRA2A transformer 2 alpha homolog (Drosophila) 0.0271303
DST dystonin 0.0268023
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0264733
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0261407
EXT1 exostosin glycosyltransferase 1 0.0260717
MORF4L2 mortality factor 4 like 2 0.0258255
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0254775
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0254199
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251095
BZW1 basic leucine zipper and W2 domains 1 0.0249758
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0248368
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0245802
IGF1R insulin-like growth factor 1 receptor 0.024535
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0241814
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0239974
CTTN cortactin 0.0239592
EEF2 eukaryotic translation elongation factor 2 0.0238553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0238246
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.023824
KDM2A lysine (K)-specific demethylase 2A 0.0237537
SEC31A SEC31 homolog A (S. cerevisiae) 0.0237245
CCNY cyclin Y 0.0236015
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.02341
TPM3 tropomyosin 3 0.0232797
R3HDM2 R3H domain containing 2 0.0231473
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0230011
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.022746
HOMER1 homer scaffolding protein 1 0.0224617
ATF6 activating transcription factor 6 0.0224043
AEBP2 AE binding protein 2 0.0223512
WWOX WW domain containing oxidoreductase 0.0221003
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0218006
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0216021
RIMS2 regulating synaptic membrane exocytosis 2 0.0215709
EXOC4 exocyst complex component 4 0.0215671
RICTOR RPTOR independent companion of MTOR, complex 2 0.021531
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0214141
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0214008
BPTF bromodomain PHD finger transcription factor 0.0213206
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0211691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0210303
DENR density-regulated protein 0.021029
ANO6 anoctamin 6 0.0207704
JMJD1C jumonji domain containing 1C 0.0205774
CAMTA1 calmodulin binding transcription activator 1 0.0204909
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.020256
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.020231
SPAG9 sperm associated antigen 9 0.0201549
ZFAND3 zinc finger, AN1-type domain 3 0.0201391
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0200673
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0199439

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.26821
TMSB10 thymosin beta 10 -0.141688
RPS21 ribosomal protein S21 -0.0720043
EGR1 early growth response 1 -0.0681706
RPL35A ribosomal protein L35a -0.0676378
PTMA prothymosin, alpha -0.0620442
TPI1 triosephosphate isomerase 1 -0.0614254
RPS3 ribosomal protein S3 -0.0553268
PFN1 profilin 1 -0.0541518
RPLP1 ribosomal protein, large, P1 -0.0538096
RPS19 ribosomal protein S19 -0.0516548
MT2A metallothionein 2A -0.0501391
RPL26 ribosomal protein L26 -0.0482838
RPL23 ribosomal protein L23 -0.0458403
RPL34 ribosomal protein L34 -0.0455167
RPL37 ribosomal protein L37 -0.045142
RPS27 ribosomal protein S27 -0.0432582
IFI6 interferon, alpha-inducible protein 6 -0.041638
HLA-B major histocompatibility complex, class I, B -0.0407455
RPL12 ribosomal protein L12 -0.0390641
MYL12B myosin, light chain 12B, regulatory -0.0383767
RPL36 ribosomal protein L36 -0.0374974
TFPI2 tissue factor pathway inhibitor 2 -0.0372437
RPLP2 ribosomal protein, large, P2 -0.0372361
RPS29 ribosomal protein S29 -0.0368148
RPS15 ribosomal protein S15 -0.0365224
POTEF POTE ankyrin domain family, member F -0.0363813
RPS12 ribosomal protein S12 -0.0354502
TXNRD1 thioredoxin reductase 1 -0.0346413
RPS6 ribosomal protein S6 -0.0343532
OSMR oncostatin M receptor -0.0342479
RPS8 ribosomal protein S8 -0.033366
RPL19 ribosomal protein L19 -0.0300031
FTL ferritin, light polypeptide -0.0282755
RPS17 ribosomal protein S17 -0.0281494
BSG basigin (Ok blood group) -0.0276041
CDK17 cyclin-dependent kinase 17 -0.0275593
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0273521
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0267364
RPL31 ribosomal protein L31 -0.0263142
RPL36A ribosomal protein L36a -0.0263105
RPL27 ribosomal protein L27 -0.0259585
TPM2 tropomyosin 2 (beta) -0.025915
RPL32 ribosomal protein L32 -0.0256239
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.025557
RPS23 ribosomal protein S23 -0.0255197
RPL5 ribosomal protein L5 -0.0252002
RPL11 ribosomal protein L11 -0.0249515
ATP5F1E ATP synthase F1 subunit epsilon -0.0249081
PTMS parathymosin -0.024766
RPL8 ribosomal protein L8 -0.0245254
RPL37A ribosomal protein L37a -0.0236969
IGF2 insulin-like growth factor 2 -0.0230551
RPS16 ribosomal protein S16 -0.0228784
RPL38 ribosomal protein L38 -0.0225625
RPS13 ribosomal protein S13 -0.0222395
RPS27A ribosomal protein S27a -0.0221157
GPX4 glutathione peroxidase 4 -0.0220951
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0215694
VIM vimentin -0.0211839
RPL9 ribosomal protein L9 -0.0211656
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0208862
RPS14 ribosomal protein S14 -0.0204101
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0200459
TUBA1B tubulin, alpha 1b -0.01986
SMC4 structural maintenance of chromosomes 4 -0.0198251
RPL35 ribosomal protein L35 -0.0195224
RPS25 ribosomal protein S25 -0.0195028
RPL28 ribosomal protein L28 -0.0183249
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0181715
GSTP1 glutathione S-transferase pi 1 -0.0180683
RPS10 ribosomal protein S10 -0.0179475
MIDN midnolin -0.0175173
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0174431
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0172321
MT1X metallothionein 1X -0.0170877
RUSC2 RUN and SH3 domain containing 2 -0.0169035
S100A6 S100 calcium binding protein A6 -0.0167194
S100A11 S100 calcium binding protein A11 -0.0166237
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0165638
YBX1 Y box binding protein 1 -0.0163928
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.016266
CBX3 chromobox homolog 3 -0.0162022
B2M beta-2-microglobulin -0.0161858
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0158435
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0154147
HLA-A major histocompatibility complex, class I, A -0.0153825
KRT18 keratin 18, type I -0.0153639
RPL10A ribosomal protein L10a -0.0151768
TAPBP TAP binding protein (tapasin) -0.0151091
S100A9 S100 calcium binding protein A9 -0.0150104
ASTN2 astrotactin 2 -0.0146761
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.0145392
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0144822
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0144277
CDCP1 CUB domain containing protein 1 -0.0143906
CENPE centromere protein E, 312kDa -0.0141257
KCMF1 potassium channel modulatory factor 1 -0.0140592
ATP5F1B ATP synthase F1 subunit beta -0.0139766
HMGA1 high mobility group AT-hook 1 -0.0139343