Gemfibrozil_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.221718
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.194468
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129968
SAMD4A sterile alpha motif domain containing 4A 0.127727
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105953
WSB1 WD repeat and SOCS box containing 1 0.0980237
APLP2 amyloid beta (A4) precursor-like protein 2 0.0968535
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0803174
SDC4 syndecan 4 0.0794895
ZSWIM6 zinc finger, SWIM-type containing 6 0.0691134
LAMB3 laminin, beta 3 0.0672488
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.064505
LMO7 LIM domain 7 0.0623664
HMGB2 high mobility group box 2 0.0609255
CANX calnexin 0.0608374
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0577833
VEGFA vascular endothelial growth factor A 0.05684
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0554588
CALR calreticulin 0.0553855
ACTG1 actin gamma 1 0.0525022
BRD2 bromodomain containing 2 0.0497279
GRB10 growth factor receptor-bound protein 10 0.0489144
SEC31A SEC31 homolog A (S. cerevisiae) 0.0477325
DSCAM Down syndrome cell adhesion molecule 0.046444
IFI16 interferon, gamma-inducible protein 16 0.0463893
GOLGB1 golgin B1 0.0455479
EXT1 exostosin glycosyltransferase 1 0.0453029
EFNA5 ephrin-A5 0.0451878
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0447866
TMF1 TATA element modulatory factor 1 0.0437815
DUSP6 dual specificity phosphatase 6 0.0437215
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0428993
ENO1 enolase 1, (alpha) 0.0428758
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0428504
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0422903
TMEM263 transmembrane protein 263 0.0409557
TM4SF1 transmembrane 4 L six family member 1 0.0396568
CTNND1 catenin (cadherin-associated protein), delta 1 0.0393917
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0387575
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0386356
AKAP13 A kinase (PRKA) anchor protein 13 0.0385351
FNIP1 folliculin interacting protein 1 0.0378713
MACF1 microtubule-actin crosslinking factor 1 0.0374923
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0374485
PTMA prothymosin, alpha 0.0373442
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0370355
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.036554
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0357122
RBM39 RNA binding motif protein 39 0.0356941
IFRD1 interferon-related developmental regulator 1 0.0352539
BLZF1 basic leucine zipper nuclear factor 1 0.0352447
DSPP dentin sialophosphoprotein 0.0348505
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0347727
INTS6 integrator complex subunit 6 0.0342929
RAD21 RAD21 homolog (S. pombe) 0.0341017
RIGI RNA sensor RIG-I 0.0338254
VGLL3 vestigial-like family member 3 0.0333372
TTC3 tetratricopeptide repeat domain 3 0.0331261
VCL vinculin 0.0331163
WWTR1 WW domain containing transcription regulator 1 0.0331038
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0329218
UBC ubiquitin C 0.0327842
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.03268
OGA O-GlcNAcase 0.0326797
TPT1 tumor protein, translationally-controlled 1 0.0324126
SGMS2 sphingomyelin synthase 2 0.0322566
KDM3A lysine (K)-specific demethylase 3A 0.0318471
NAP1L1 nucleosome assembly protein 1-like 1 0.0318127
RBM25 RNA binding motif protein 25 0.0317037
TPR translocated promoter region, nuclear basket protein 0.031689
IQGAP1 IQ motif containing GTPase activating protein 1 0.0313832
ENO2 enolase 2 (gamma, neuronal) 0.0311477
ZFC3H1 zinc finger, C3H1-type containing 0.0310112
AFF1 AF4/FMR2 family, member 1 0.030916
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0297782
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0297745
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0296478
CSDE1 cold shock domain containing E1, RNA-binding 0.02921
EZR ezrin 0.0289417
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0288356
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0286477
HDAC9 histone deacetylase 9 0.0283968
PALLD palladin, cytoskeletal associated protein 0.027739
LDHA lactate dehydrogenase A 0.0277221
BZW1 basic leucine zipper and W2 domains 1 0.0275563
CENPE centromere protein E, 312kDa 0.0275006
MED13 mediator complex subunit 13 0.0274002
MX1 MX dynamin-like GTPase 1 0.0271301
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0270594
HLA-E major histocompatibility complex, class I, E 0.0270036
CD44 CD44 molecule (Indian blood group) 0.0269582
MORF4L2 mortality factor 4 like 2 0.0269358
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0268559
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0267812
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0267198
TOP1 topoisomerase (DNA) I 0.0266527
CTTN cortactin 0.0262922
PGBD5 piggyBac transposable element derived 5 0.0262639
RSRC2 arginine/serine-rich coiled-coil 2 0.0258932
MCTP2 multiple C2 domains, transmembrane 2 0.0257107

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.236741
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.186528
TMSB10 thymosin beta 10 -0.117876
RPS6 ribosomal protein S6 -0.110195
S100A6 S100 calcium binding protein A6 -0.105931
NDRG1 N-myc downstream regulated 1 -0.0876447
FTH1 ferritin, heavy polypeptide 1 -0.0867611
POTEF POTE ankyrin domain family, member F -0.0767291
IFI27 interferon, alpha-inducible protein 27 -0.0760532
RPL35A ribosomal protein L35a -0.0748327
RPLP1 ribosomal protein, large, P1 -0.0747069
IGFBP3 insulin-like growth factor binding protein 3 -0.0683782
RPS19 ribosomal protein S19 -0.0661418
TMSB4X thymosin beta 4, X-linked -0.0660401
KRT7 keratin 7, type II -0.0633977
ISG15 ISG15 ubiquitin-like modifier -0.0606696
RPLP2 ribosomal protein, large, P2 -0.0593296
HMGA1 high mobility group AT-hook 1 -0.0562787
RPL11 ribosomal protein L11 -0.0559518
RPL19 ribosomal protein L19 -0.0531771
RPL34 ribosomal protein L34 -0.0524754
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0517682
RPL23 ribosomal protein L23 -0.0516534
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.051282
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0497508
S100A10 S100 calcium binding protein A10 -0.048561
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0482945
RPS23 ribosomal protein S23 -0.0463699
LPP LIM domain containing preferred translocation partner in lipoma -0.046294
RPL5 ribosomal protein L5 -0.0443587
RPS14 ribosomal protein S14 -0.0442749
TFG TRK-fused gene -0.0422872
RPL8 ribosomal protein L8 -0.0401102
RPS21 ribosomal protein S21 -0.0385698
RPL32 ribosomal protein L32 -0.0383612
SLC38A1 solute carrier family 38, member 1 -0.0381399
GPX4 glutathione peroxidase 4 -0.0378136
MDK midkine (neurite growth-promoting factor 2) -0.0373626
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.036241
CSTB cystatin B (stefin B) -0.0356425
HSPB1 heat shock 27kDa protein 1 -0.035528
LOC112694756 uncharaterized LOC112694756 -0.0349535
GNAS GNAS complex locus -0.0341653
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0339917
RPL12 ribosomal protein L12 -0.033968
UGCG UDP-glucose ceramide glucosyltransferase -0.0338077
FAM3C family with sequence similarity 3, member C -0.0336719
RPL36 ribosomal protein L36 -0.0321178
COX7C cytochrome c oxidase subunit VIIc -0.0312588
ANXA5 annexin A5 -0.030973
RPS16 ribosomal protein S16 -0.0306928
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0306188
YBX1 Y box binding protein 1 -0.0304903
MATR3 matrin 3 -0.0303021
RPL36A ribosomal protein L36a -0.0300026
DSTN destrin (actin depolymerizing factor) -0.0299463
NRIP1 nuclear receptor interacting protein 1 -0.0296215
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0294172
RPL27A ribosomal protein L27a -0.0294001
RHOA ras homolog family member A -0.0293511
SLMAP sarcolemma associated protein -0.0292269
LY6E lymphocyte antigen 6 complex, locus E -0.0288469
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0287819
GOLGA4 golgin A4 -0.0285902
PGK1 phosphoglycerate kinase 1 -0.0285518
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0284641
SRPK2 SRSF protein kinase 2 -0.0284172
NPEPPS aminopeptidase puromycin sensitive -0.0277518
RPL28 ribosomal protein L28 -0.0274554
RPS2 ribosomal protein S2 -0.0271412
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0269367
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0267841
ADAM9 ADAM metallopeptidase domain 9 -0.0267655
RPS25 ribosomal protein S25 -0.0264294
RPL15 ribosomal protein L15 -0.0263283
LMNA lamin A/C -0.0262627
NDFIP1 Nedd4 family interacting protein 1 -0.0259803
KRT18 keratin 18, type I -0.0256608
CCND1 cyclin D1 -0.0249663
ASTN2 astrotactin 2 -0.024613
ADAR adenosine deaminase, RNA-specific -0.0245823
RPS11 ribosomal protein S11 -0.0243967
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0240834
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0239948
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0239259
SETD5 SET domain containing 5 -0.0238702
RPL3 ribosomal protein L3 -0.0237386
TRAM1 translocation associated membrane protein 1 -0.0236942
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0236651
KRT19 keratin 19, type I -0.0236614
GRB2 growth factor receptor-bound protein 2 -0.0232797
RPS27 ribosomal protein S27 -0.0232607
RPL35 ribosomal protein L35 -0.0232387
F3 coagulation factor III (thromboplastin, tissue factor) -0.0230024
RPS5 ribosomal protein S5 -0.0228362
WAC WW domain containing adaptor with coiled-coil -0.0227238
MSMO1 methylsterol monooxygenase 1 -0.0225058
PDIA3 protein disulfide isomerase family A, member 3 -0.0224786
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0222869
HMGN2 high mobility group nucleosomal binding domain 2 -0.0221233