Gemfibrozil_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.161691
KYNU kynureninase 0.124682
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123335
DST dystonin 0.1147
COL5A2 collagen, type V, alpha 2 0.0979195
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0975612
SH3KBP1 SH3-domain kinase binding protein 1 0.0908004
COL8A1 collagen, type VIII, alpha 1 0.0905846
GDA guanine deaminase 0.086774
TRIO trio Rho guanine nucleotide exchange factor 0.0857985
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0798908
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0765287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.074787
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0747662
SLC38A2 solute carrier family 38, member 2 0.0730899
PDLIM5 PDZ and LIM domain 5 0.0727639
FMNL2 formin-like 2 0.0722124
ASPH aspartate beta-hydroxylase 0.0721153
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0709167
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0657155
AKAP13 A kinase (PRKA) anchor protein 13 0.0598484
GRAMD1B GRAM domain containing 1B 0.0585416
SMAD2 SMAD family member 2 0.0570882
DOCK4 dedicator of cytokinesis 4 0.0539557
PSD3 pleckstrin and Sec7 domain containing 3 0.0532035
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.053117
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0528188
NAP1L1 nucleosome assembly protein 1-like 1 0.0519635
ZSWIM6 zinc finger, SWIM-type containing 6 0.0505728
VCL vinculin 0.0504863
RAB3B RAB3B, member RAS oncogene family 0.0493501
INTS6 integrator complex subunit 6 0.0484741
LDHA lactate dehydrogenase A 0.0478058
MAML3 mastermind-like 3 (Drosophila) 0.0477999
MYOF myoferlin 0.0475463
TGFBR1 transforming growth factor, beta receptor 1 0.0468062
DOCK5 dedicator of cytokinesis 5 0.046416
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0462892
CANX calnexin 0.0447758
ZEB2 zinc finger E-box binding homeobox 2 0.0445305
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0442017
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0424044
ATXN1 ataxin 1 0.0413436
JMJD1C jumonji domain containing 1C 0.041005
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0409768
LIMCH1 LIM and calponin homology domains 1 0.0407175
CXCL8 chemokine (C-X-C motif) ligand 8 0.0403665
CSNK1A1 casein kinase 1, alpha 1 0.0399562
DNER delta/notch-like EGF repeat containing 0.0396839
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0396082
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0395758
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0391666
SMOC1 SPARC related modular calcium binding 1 0.0388752
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0388441
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.038689
NEK7 NIMA-related kinase 7 0.0383035
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0379372
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0377753
FNDC3A fibronectin type III domain containing 3A 0.0376837
PTEN phosphatase and tensin homolog 0.0376698
BZW1 basic leucine zipper and W2 domains 1 0.0375785
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0371387
TPR translocated promoter region, nuclear basket protein 0.0370697
MCL1 myeloid cell leukemia 1 0.0367505
SAMD4A sterile alpha motif domain containing 4A 0.0360238
STC1 stanniocalcin 1 0.0348695
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.034785
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0336778
AKAP12 A kinase (PRKA) anchor protein 12 0.0327796
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0322796
FNIP1 folliculin interacting protein 1 0.0320532
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0319246
SET SET nuclear proto-oncogene 0.0317653
COL4A5 collagen, type IV, alpha 5 0.0307757
UBC ubiquitin C 0.0300082
CARD16 caspase recruitment domain family, member 16 0.0295832
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0295159
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0295051
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0292304
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0291559
ANKRD17 ankyrin repeat domain 17 0.0288531
IQGAP1 IQ motif containing GTPase activating protein 1 0.0287972
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286796
EXT1 exostosin glycosyltransferase 1 0.028679
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0286234
BCAR3 breast cancer anti-estrogen resistance 3 0.0285463
DSCAM Down syndrome cell adhesion molecule 0.0279571
EZR ezrin 0.0278494
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0275816
PTK2 protein tyrosine kinase 2 0.0275593
ELL2 elongation factor, RNA polymerase II, 2 0.0273216
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0269786
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0269092
RAB10 RAB10, member RAS oncogene family 0.0268965
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0268066
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.026735
SQSTM1 sequestosome 1 0.0267325
TOP1 topoisomerase (DNA) I 0.026611
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0266007
ERBIN erbb2 interacting protein 0.0265077

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.154801
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120708
TMSB10 thymosin beta 10 -0.115286
PDE4D phosphodiesterase 4D, cAMP-specific -0.104671
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0656317
RPS6 ribosomal protein S6 -0.0635823
RPLP1 ribosomal protein, large, P1 -0.0583478
RPL35A ribosomal protein L35a -0.0557582
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.050172
RPS19 ribosomal protein S19 -0.0491233
ADGRD1 adhesion G protein-coupled receptor D1 -0.048962
WARS1 tryptophanyl-tRNA synthetase 1 -0.0465084
LSAMP limbic system-associated membrane protein -0.0452444
RPS21 ribosomal protein S21 -0.0422931
PCBP3 poly(rC) binding protein 3 -0.0420007
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0397927
RPL34 ribosomal protein L34 -0.0388668
RPL12 ribosomal protein L12 -0.0385631
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0381269
RPL23 ribosomal protein L23 -0.0377228
RPS27 ribosomal protein S27 -0.0373096
NCKAP5 NCK-associated protein 5 -0.0370233
FTL ferritin, light polypeptide -0.0355468
NALF1 NALCN channel auxiliary factor 1 -0.0347645
EFNA5 ephrin-A5 -0.0336305
RPL36 ribosomal protein L36 -0.0335156
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0328546
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.032383
RPS23 ribosomal protein S23 -0.0320195
PYGL phosphorylase, glycogen, liver -0.0306288
RPL31 ribosomal protein L31 -0.0302353
MT2A metallothionein 2A -0.0299766
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0270632
RPL35 ribosomal protein L35 -0.0269283
RPL36A ribosomal protein L36a -0.0262202
RPS13 ribosomal protein S13 -0.0260814
NRCAM neuronal cell adhesion molecule -0.0256816
NAMPT nicotinamide phosphoribosyltransferase -0.0255865
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0253305
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0250617
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0244403
RPS29 ribosomal protein S29 -0.0243452
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224508
SOX6 SRY (sex determining region Y)-box 6 -0.0217162
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0216888
OSMR oncostatin M receptor -0.0213562
RPS16 ribosomal protein S16 -0.0212699
TGFBI transforming growth factor, beta-induced, 68kDa -0.0205678
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0204744
ISG15 ISG15 ubiquitin-like modifier -0.0204218
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0198663
RPL26 ribosomal protein L26 -0.0194495
LAMA5 laminin, alpha 5 -0.0190586
BMERB1 bMERB domain containing 1 -0.0190386
OASL 2'-5'-oligoadenylate synthetase-like -0.0190318
RPL19 ribosomal protein L19 -0.018476
RPL38 ribosomal protein L38 -0.0184145
IGFBP3 insulin-like growth factor binding protein 3 -0.0182475
TTC28 tetratricopeptide repeat domain 28 -0.0178182
PCDH15 protocadherin-related 15 -0.0172201
BCAS3 breast carcinoma amplified sequence 3 -0.0172193
PTMA prothymosin, alpha -0.0167827
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0165994
RPS15 ribosomal protein S15 -0.0162405
ADGRB3 adhesion G protein-coupled receptor B3 -0.0161338
IGFBP6 insulin-like growth factor binding protein 6 -0.0161181
CADM2 cell adhesion molecule 2 -0.0160933
RPS28 ribosomal protein S28 -0.0160334
RPS14 ribosomal protein S14 -0.0158685
S100A6 S100 calcium binding protein A6 -0.0157004
KIAA0825 KIAA0825 -0.0153764
ATP5F1E ATP synthase F1 subunit epsilon -0.0151644
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0150069
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0149544
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0142852
RPS27A ribosomal protein S27a -0.0139905
HLA-A major histocompatibility complex, class I, A -0.0139392
CCL5 chemokine (C-C motif) ligand 5 -0.0139068
SMYD3 SET and MYND domain containing 3 -0.0138937
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0138462
CDH13 cadherin 13 -0.0137554
PCED1B PC-esterase domain containing 1B -0.0137039
NCAM2 neural cell adhesion molecule 2 -0.0135063
RPL27 ribosomal protein L27 -0.0134797
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.013471
PCDH9 protocadherin 9 -0.013423
RPL37A ribosomal protein L37a -0.0132275
LOC112694756 uncharaterized LOC112694756 -0.0131897
SAR1A secretion associated, Ras related GTPase 1A -0.0131267
CTSL cathepsin L -0.0130955
HLA-B major histocompatibility complex, class I, B -0.0128806
RPLP2 ribosomal protein, large, P2 -0.0128045
STEAP1B STEAP family member 1B -0.0125742
TBXT T-box transcription factor T -0.0124869
FTH1 ferritin, heavy polypeptide 1 -0.0123577
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.0122805
LAMB1 laminin, beta 1 -0.0122632
RPL8 ribosomal protein L8 -0.0122202
RPH3AL rabphilin 3A-like (without C2 domains) -0.0121455
RPL32 ribosomal protein L32 -0.012141