Gemfibrozil_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.136123
DSCAM Down syndrome cell adhesion molecule 0.0992744
PDGFC platelet derived growth factor C 0.0936797
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0792589
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0739117
HDAC9 histone deacetylase 9 0.0727099
JMJD1C jumonji domain containing 1C 0.0719335
EGFR epidermal growth factor receptor 0.0672064
ZNF608 zinc finger protein 608 0.0642944
ZNF292 zinc finger protein 292 0.0601238
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0578684
MED13 mediator complex subunit 13 0.0562546
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0560417
SLC38A2 solute carrier family 38, member 2 0.0527614
NAP1L1 nucleosome assembly protein 1-like 1 0.0521653
KMT2E lysine (K)-specific methyltransferase 2E 0.0510209
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0508055
ZBTB20 zinc finger and BTB domain containing 20 0.0491965
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0490046
AKAP9 A kinase (PRKA) anchor protein 9 0.0477207
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0476403
FOXP1 forkhead box P1 0.0466011
NCEH1 neutral cholesterol ester hydrolase 1 0.046081
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0452085
PRRC2C proline-rich coiled-coil 2C 0.0439091
SMC3 structural maintenance of chromosomes 3 0.0431247
ASPH aspartate beta-hydroxylase 0.0419213
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0416996
GOLGA4 golgin A4 0.0414668
WAC WW domain containing adaptor with coiled-coil 0.0413365
INTS6 integrator complex subunit 6 0.0410017
OGA O-GlcNAcase 0.0409178
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0407142
TTC3 tetratricopeptide repeat domain 3 0.0405946
EXT1 exostosin glycosyltransferase 1 0.0398112
EML4 echinoderm microtubule associated protein like 4 0.039497
RBM39 RNA binding motif protein 39 0.0392116
ANXA1 annexin A1 0.0374823
CSNK1A1 casein kinase 1, alpha 1 0.0368814
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.036859
MED13L mediator complex subunit 13-like 0.0362957
RTN4 reticulon 4 0.0357953
B2M beta-2-microglobulin 0.0356721
ANKRD12 ankyrin repeat domain 12 0.0355933
PTK2 protein tyrosine kinase 2 0.0353914
KDM3A lysine (K)-specific demethylase 3A 0.0353651
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0353343
ANKRD17 ankyrin repeat domain 17 0.034827
EZR ezrin 0.0345882
ANKRD36C ankyrin repeat domain 36C 0.0339391
RBM26 RNA binding motif protein 26 0.0338185
KTN1 kinectin 1 (kinesin receptor) 0.0336631
ECT2 epithelial cell transforming 2 0.033516
PHIP pleckstrin homology domain interacting protein 0.0332107
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0331251
FMNL2 formin-like 2 0.0329286
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0328314
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0326208
ZNF638 zinc finger protein 638 0.0325631
CALU calumenin 0.0323764
ARL4C ADP-ribosylation factor-like 4C 0.0323437
QKI QKI, KH domain containing, RNA binding 0.0320957
TNRC6B trinucleotide repeat containing 6B 0.0320504
FNIP1 folliculin interacting protein 1 0.0317621
ANKRD36 ankyrin repeat domain 36 0.0317086
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0314085
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0312713
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0310075
NFE2L2 nuclear factor, erythroid 2-like 2 0.0309333
EIF4A2 eukaryotic translation initiation factor 4A2 0.0308761
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0308132
ANXA3 annexin A3 0.0308108
BRD2 bromodomain containing 2 0.0305625
RICTOR RPTOR independent companion of MTOR, complex 2 0.0303932
NCOA3 nuclear receptor coactivator 3 0.0300783
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0300228
YAP1 Yes-associated protein 1 0.029986
IARS1 isoleucyl-tRNA synthetase 1 0.0299763
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0297681
TCF12 transcription factor 12 0.0293818
TRIO trio Rho guanine nucleotide exchange factor 0.0293628
CTNND1 catenin (cadherin-associated protein), delta 1 0.0292002
ZSWIM6 zinc finger, SWIM-type containing 6 0.029154
CLIP1 CAP-GLY domain containing linker protein 1 0.0289881
CCNY cyclin Y 0.0288747
FGFR2 fibroblast growth factor receptor 2 0.028744
NAMPT nicotinamide phosphoribosyltransferase 0.0284844
SPAG9 sperm associated antigen 9 0.0282002
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0280092
IFI16 interferon, gamma-inducible protein 16 0.0279249
ARL15 ADP-ribosylation factor-like 15 0.0279055
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0278708
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278596
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0276637
XPO1 exportin 1 0.0273048
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0272798
UBC ubiquitin C 0.0272232
APLP2 amyloid beta (A4) precursor-like protein 2 0.0271686
ZFAND3 zinc finger, AN1-type domain 3 0.0270912
SEC31A SEC31 homolog A (S. cerevisiae) 0.026968

decreased expression

Symbol Name Standardized Value
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.148564
AHNAK AHNAK nucleoprotein -0.13573
CPED1 cadherin-like and PC-esterase domain containing 1 -0.117002
PTMA prothymosin, alpha -0.0975069
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0939546
PDE4B phosphodiesterase 4B, cAMP-specific -0.0831962
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0793534
RPS6 ribosomal protein S6 -0.0747327
BMP10 bone morphogenetic protein 10 -0.069954
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0690306
MKI67 marker of proliferation Ki-67 -0.0672984
DLG1 discs, large homolog 1 (Drosophila) -0.0672588
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0652289
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0610147
FLNB filamin B, beta -0.059706
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0555662
SOX6 SRY (sex determining region Y)-box 6 -0.0522
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0513792
RPL35A ribosomal protein L35a -0.048966
HJURP Holliday junction recognition protein -0.0481702
UNC13A unc-13 homolog A (C. elegans) -0.0456949
CAMKMT calmodulin-lysine N-methyltransferase -0.0444077
TMSB4X thymosin beta 4, X-linked -0.0435386
PDE7B phosphodiesterase 7B -0.0420444
S100A6 S100 calcium binding protein A6 -0.0406952
GLI2 GLI family zinc finger 2 -0.0405569
S100A4 S100 calcium binding protein A4 -0.0405388
RPLP1 ribosomal protein, large, P1 -0.0398525
NBEA neurobeachin -0.0394225
TTC28 tetratricopeptide repeat domain 28 -0.0390948
EBNA1BP2 EBNA1 binding protein 2 -0.0388134
RPS21 ribosomal protein S21 -0.0377768
SDK1 sidekick cell adhesion molecule 1 -0.0376734
GSE1 Gse1 coiled-coil protein -0.0375564
RPS19 ribosomal protein S19 -0.0368354
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0364904
RPL34 ribosomal protein L34 -0.0344418
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0321401
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0314061
NEBL nebulette -0.0305446
EVI5 ecotropic viral integration site 5 -0.0299784
PTPRG protein tyrosine phosphatase, receptor type, G -0.0285284
PYGB phosphorylase, glycogen; brain -0.028521
HSPB1 heat shock 27kDa protein 1 -0.0275292
NAV2 neuron navigator 2 -0.0271696
PKM pyruvate kinase, muscle -0.0270531
LOXL3 lysyl oxidase-like 3 -0.0268862
GLI3 GLI family zinc finger 3 -0.0266294
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0263397
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262837
NFIA nuclear factor I/A -0.0259704
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0257159
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0253293
RPL11 ribosomal protein L11 -0.0250542
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245812
RPS13 ribosomal protein S13 -0.0244743
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0239128
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0237127
RPLP0 ribosomal protein, large, P0 -0.0235896
HMGB1 high mobility group box 1 -0.023579
RFC3 replication factor C (activator 1) 3, 38kDa -0.0231157
TUBB4B tubulin, beta 4B class IVb -0.0231034
PLXNA2 plexin A2 -0.0223649
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0222002
CENPF centromere protein F, 350/400kDa -0.0221565
CENPE centromere protein E, 312kDa -0.0221317
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0220314
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0218154
XXYLT1 xyloside xylosyltransferase 1 -0.0218028
PKP4 plakophilin 4 -0.0216488
RPL26 ribosomal protein L26 -0.0214581
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0214181
AFG2A AFG2 AAA ATPase homolog A -0.0209446
LPP LIM domain containing preferred translocation partner in lipoma -0.0207085
CD47 CD47 molecule -0.0206383
ZNF407 zinc finger protein 407 -0.0203281
RPL35 ribosomal protein L35 -0.0202778
S100A9 S100 calcium binding protein A9 -0.0201386
PRC1 protein regulator of cytokinesis 1 -0.0200181
RPL23 ribosomal protein L23 -0.0199011
SH3D19 SH3 domain containing 19 -0.0197461
PLXNA1 plexin A1 -0.0196211
DOCK1 dedicator of cytokinesis 1 -0.0192174
LOC112694756 uncharaterized LOC112694756 -0.0190603
ZNF438 zinc finger protein 438 -0.0189164
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0188118
FAM114A1 family with sequence similarity 114, member A1 -0.0187889
RPL19 ribosomal protein L19 -0.0187512
ARHGAP11A Rho GTPase activating protein 11A -0.0186411
SMNDC1 survival motor neuron domain containing 1 -0.0186387
RRBP1 ribosome binding protein 1 -0.018624
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0186155
IFITM1 interferon induced transmembrane protein 1 -0.0183557
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0178929
EIF4H eukaryotic translation initiation factor 4H -0.0178754
FHIT fragile histidine triad -0.0177542
RPS27 ribosomal protein S27 -0.0177428
BCL2 B-cell CLL/lymphoma 2 -0.0176997
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0176794
TRAF3 TNF receptor-associated factor 3 -0.0175904