Gemfibrozil_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gemfibrozil perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gemfibrozil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0622596
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0588718
CXCL8 chemokine (C-X-C motif) ligand 8 0.0500286
APLP2 amyloid beta (A4) precursor-like protein 2 0.0486909
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0438056
VEGFA vascular endothelial growth factor A 0.0435651
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0425601
ZSWIM6 zinc finger, SWIM-type containing 6 0.0417879
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0403493
INTS6 integrator complex subunit 6 0.0402364
CANX calnexin 0.0391559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0372732
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0353888
FNDC3B fibronectin type III domain containing 3B 0.0335265
AKAP12 A kinase (PRKA) anchor protein 12 0.0315159
CTBP2 C-terminal binding protein 2 0.0314086
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0295686
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0295281
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0295095
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0292809
PICALM phosphatidylinositol binding clathrin assembly protein 0.0277151
RNF145 ring finger protein 145 0.0271584
PTK2 protein tyrosine kinase 2 0.0267058
MBNL1 muscleblind-like splicing regulator 1 0.0263387
FNDC3A fibronectin type III domain containing 3A 0.0259314
TRIO trio Rho guanine nucleotide exchange factor 0.0254579
EXT1 exostosin glycosyltransferase 1 0.0249863
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0249112
OGA O-GlcNAcase 0.0235068
SHB Src homology 2 domain containing adaptor protein B 0.0234841
SMAD3 SMAD family member 3 0.0232739
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0224098
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0221455
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0220766
DSCAM Down syndrome cell adhesion molecule 0.0219907
NPAS2 neuronal PAS domain protein 2 0.02167
PDLIM5 PDZ and LIM domain 5 0.0212437
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0208651
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0207251
NEK7 NIMA-related kinase 7 0.0201463
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0200966
YAP1 Yes-associated protein 1 0.0200585
CUL3 cullin 3 0.0199193
ELL2 elongation factor, RNA polymerase II, 2 0.0197974
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0196991
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0195116
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0191997
ZNF638 zinc finger protein 638 0.0191839
MACF1 microtubule-actin crosslinking factor 1 0.0190871
SUCO SUN domain containing ossification factor 0.0189436
SPAG9 sperm associated antigen 9 0.0189205
FMNL2 formin-like 2 0.0186375
CSNK1A1 casein kinase 1, alpha 1 0.0185737
FAM13A family with sequence similarity 13, member A 0.0184373
HELZ helicase with zinc finger 0.0183564
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0181484
SIRT1 sirtuin 1 0.0181398
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0181315
SEPTIN9 septin 9 0.018082
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0180057
AKAP13 A kinase (PRKA) anchor protein 13 0.017923
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0177807
SOD2 superoxide dismutase 2, mitochondrial 0.0177034
AFDN afadin, adherens junction formation factor 0.0174038
PDIA4 protein disulfide isomerase family A, member 4 0.0173014
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0169522
ANKRD36 ankyrin repeat domain 36 0.0168969
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168815
ERBIN erbb2 interacting protein 0.0166645
FERMT2 fermitin family member 2 0.0165693
PAPOLA poly(A) polymerase alpha 0.0165601
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.016446
ANKRD28 ankyrin repeat domain 28 0.0163999
NUMB numb homolog (Drosophila) 0.0162638
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0162371
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0162034
CDC73 cell division cycle 73 0.0161959
TRA2A transformer 2 alpha homolog (Drosophila) 0.0161812
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0161683
COG6 component of oligomeric golgi complex 6 0.0161629
USP9X ubiquitin specific peptidase 9, X-linked 0.0161002
TTC3 tetratricopeptide repeat domain 3 0.0159988
SIK3 SIK family kinase 3 0.0159968
GLS2 glutaminase 2 (liver, mitochondrial) 0.0158776
YTHDC1 YTH domain containing 1 0.0156792
FAT1 FAT atypical cadherin 1 0.0156493
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0156054
WWTR1 WW domain containing transcription regulator 1 0.0155264
BIRC6 baculoviral IAP repeat containing 6 0.0154951
NPTN neuroplastin 0.0154753
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0154518
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0153854
FBXW11 F-box and WD repeat domain containing 11 0.0153646
EPS8 epidermal growth factor receptor pathway substrate 8 0.0153542
HILPDA hypoxia inducible lipid droplet-associated 0.0153357
HSPA8 heat shock 70kDa protein 8 0.0153245
NRIP1 nuclear receptor interacting protein 1 0.0152792
CORO1C coronin, actin binding protein, 1C 0.0151147
SLC38A2 solute carrier family 38, member 2 0.0149474
RBM39 RNA binding motif protein 39 0.0149318

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.277566
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.264513
FN1 fibronectin 1 -0.221614
NRG1 neuregulin 1 -0.145883
TMSB10 thymosin beta 10 -0.123356
IFI27 interferon, alpha-inducible protein 27 -0.105529
S100A6 S100 calcium binding protein A6 -0.104539
MT2A metallothionein 2A -0.0968408
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0953954
HLA-B major histocompatibility complex, class I, B -0.0904552
PTMA prothymosin, alpha -0.0867631
SQSTM1 sequestosome 1 -0.0771229
VIM vimentin -0.0662803
FTL ferritin, light polypeptide -0.0623128
RPL35A ribosomal protein L35a -0.061898
TMSB4X thymosin beta 4, X-linked -0.0595993
OSMR oncostatin M receptor -0.0560526
TMEM156 transmembrane protein 156 -0.0521358
HMGA2 high mobility group AT-hook 2 -0.0521071
RPS6 ribosomal protein S6 -0.0478012
SYT1 synaptotagmin I -0.0445683
SOX4 SRY (sex determining region Y)-box 4 -0.0431918
ETV1 ets variant 1 -0.0428229
ACTG1 actin gamma 1 -0.0425388
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0423717
RPS21 ribosomal protein S21 -0.0417094
IFI16 interferon, gamma-inducible protein 16 -0.0414191
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0403558
LOC102724023 ES1 protein homolog, mitochondrial -0.0398449
RPLP1 ribosomal protein, large, P1 -0.0395091
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0380135
B2M beta-2-microglobulin -0.0376123
EIF1 eukaryotic translation initiation factor 1 -0.0373735
TPT1 tumor protein, translationally-controlled 1 -0.0356327
EGR1 early growth response 1 -0.0350836
HMGA1 high mobility group AT-hook 1 -0.0345289
LMNA lamin A/C -0.0340165
LY6E lymphocyte antigen 6 complex, locus E -0.0339384
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0332768
EFNA5 ephrin-A5 -0.0331206
KLHL5 kelch-like family member 5 -0.0326626
IFI6 interferon, alpha-inducible protein 6 -0.0325527
MKI67 marker of proliferation Ki-67 -0.0319079
MAP1B microtubule-associated protein 1B -0.0317972
RPS19 ribosomal protein S19 -0.0312189
POTEF POTE ankyrin domain family, member F -0.0311531
ITGA1 integrin, alpha 1 -0.0303557
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0303394
ZMYND8 zinc finger, MYND-type containing 8 -0.0299171
RPL9 ribosomal protein L9 -0.0297664
RPLP0 ribosomal protein, large, P0 -0.0293309
MX2 MX dynamin-like GTPase 2 -0.0289153
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028421
S100A9 S100 calcium binding protein A9 -0.0283928
RPL34 ribosomal protein L34 -0.0283915
CTSD cathepsin D -0.0281254
ZBTB20 zinc finger and BTB domain containing 20 -0.0278002
PLIN2 perilipin 2 -0.0276751
RPL37A ribosomal protein L37a -0.0276425
KPNB1 karyopherin (importin) beta 1 -0.0276418
RPS24 ribosomal protein S24 -0.0267856
RPL11 ribosomal protein L11 -0.0266362
S100A10 S100 calcium binding protein A10 -0.0261168
RPS8 ribosomal protein S8 -0.0256665
HLA-A major histocompatibility complex, class I, A -0.0255411
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0254276
RPS16 ribosomal protein S16 -0.0250647
TPI1 triosephosphate isomerase 1 -0.0248427
RPL31 ribosomal protein L31 -0.0247744
ASPH aspartate beta-hydroxylase -0.024747
PRRC2C proline-rich coiled-coil 2C -0.0247354
CENPF centromere protein F, 350/400kDa -0.0246517
DPYD dihydropyrimidine dehydrogenase -0.0244411
GLIS3 GLIS family zinc finger 3 -0.024424
TFPI2 tissue factor pathway inhibitor 2 -0.0240463
RPL26 ribosomal protein L26 -0.0240446
FOXP1 forkhead box P1 -0.0238657
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0238603
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0236601
RPL23 ribosomal protein L23 -0.0233066
CD63 CD63 molecule -0.0232765
RPLP2 ribosomal protein, large, P2 -0.0232194
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0227678
IFITM1 interferon induced transmembrane protein 1 -0.0225741
RPS25 ribosomal protein S25 -0.0223398
RPL19 ribosomal protein L19 -0.0222858
FAF2 Fas associated factor family member 2 -0.0222702
RPL12 ribosomal protein L12 -0.0219979
LOC112694756 uncharaterized LOC112694756 -0.0218024
TAS2R14 taste receptor, type 2, member 14 -0.0218021
SERF2 small EDRK-rich factor 2 -0.0214653
RPL38 ribosomal protein L38 -0.0212674
ETV6 ets variant 6 -0.0212257
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0211323
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0208953
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0206574
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0206233
H3-3B H3.3 histone B -0.0204079
DNAH5 dynein, axonemal, heavy chain 5 -0.019874
RPL8 ribosomal protein L8 -0.0198509