| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. (Chemical Entities of Biological Interest Ontology, CHEBI_28088) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5280961 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Genistein relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRB | protein tyrosine phosphatase, receptor type, B | 1.3 |
| ADCY10 | adenylate cyclase 10 (soluble) | 1.2 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 1.11 |
| WWC3 | WWC family member 3 | 1.02 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.99 |
| HMCN1 | hemicentin 1 | 0.96 |
| TIGD1 | tigger transposable element derived 1 | 0.95 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.72 |
| DCHS1 | dachsous cadherin-related 1 | 0.6 |
| DENND4B | DENN/MADD domain containing 4B | 0.59 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.55 |
| STARD3NL | STARD3 N-terminal like | 0.54 |
| GBA2 | glucosidase, beta (bile acid) 2 | 0.54 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.54 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 0.54 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.49 |
| TBP | TATA box binding protein | 0.49 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.48 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.48 |
| RRN3 | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) | 0.47 |
| CCND3 | cyclin D3 | 0.47 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.46 |
| SH2D5 | SH2 domain containing 5 | 0.46 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.46 |
| PMFBP1 | polyamine modulated factor 1 binding protein 1 | 0.45 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.45 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.44 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.44 |
| MICB | MHC class I polypeptide-related sequence B | 0.43 |
| BOD1 | biorientation of chromosomes in cell division 1 | 0.43 |
| TMEM106C | transmembrane protein 106C | 0.43 |
| NECTIN1 | nectin cell adhesion molecule 1 | 0.42 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.41 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.41 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.41 |
| SETD3 | SET domain containing 3 | 0.4 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.4 |
| PRDM2 | PR domain containing 2, with ZNF domain | 0.39 |
| PROSER3 | proline and serine rich 3 | 0.39 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.39 |
| FBXO33 | F-box protein 33 | 0.39 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.39 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.39 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.38 |
| ABAT | 4-aminobutyrate aminotransferase | 0.37 |
| RWDD1 | RWD domain containing 1 | 0.37 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.37 |
| CD151 | CD151 molecule (Raph blood group) | 0.36 |
| ZNF503 | zinc finger protein 503 | 0.36 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.36 |
| TPM1 | tropomyosin 1 (alpha) | 0.35 |
| FDXR | ferredoxin reductase | 0.35 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | 0.35 |
| EGR1 | early growth response 1 | 0.35 |
| SVIP | small VCP/p97-interacting protein | 0.35 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.35 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.34 |
| ZBTB6 | zinc finger and BTB domain containing 6 | 0.34 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.34 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.34 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.34 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.34 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | 0.33 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.33 |
| FAM76A | family with sequence similarity 76, member A | 0.33 |
| DEPDC1 | DEP domain containing 1 | 0.33 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | 0.33 |
| SARDH | sarcosine dehydrogenase | 0.33 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.33 |
| DNLZ | DNL-type zinc finger | 0.32 |
| SLC35E1 | solute carrier family 35, member E1 | 0.32 |
| MYBPC1 | myosin binding protein C, slow type | 0.32 |
| DNAH8 | dynein, axonemal, heavy chain 8 | 0.32 |
| ARMC7 | armadillo repeat containing 7 | 0.32 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.31 |
| COQ4 | coenzyme Q4 | 0.31 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.31 |
| MTRF1 | mitochondrial translational release factor 1 | 0.31 |
| MRPL52 | mitochondrial ribosomal protein L52 | 0.31 |
| FAM3A | family with sequence similarity 3, member A | 0.31 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.3 |
| CCDC112 | coiled-coil domain containing 112 | 0.3 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 0.3 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.3 |
| MED10 | mediator complex subunit 10 | 0.3 |
| DSCAM | Down syndrome cell adhesion molecule | 0.3 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.3 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.3 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.3 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.29 |
| YIPF1 | Yip1 domain family, member 1 | 0.29 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.29 |
| TRAF3 | TNF receptor-associated factor 3 | 0.29 |
| E2F7 | E2F transcription factor 7 | 0.29 |
| ZNF428 | zinc finger protein 428 | 0.29 |
| FAS | Fas cell surface death receptor | 0.29 |
| FAT3 | FAT atypical cadherin 3 | 0.29 |
| TMEM131L | transmembrane 131 like | 0.29 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.28 |
| MAGEF1 | melanoma antigen family F1 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MEGF8 | multiple EGF-like-domains 8 | -0.69 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.69 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.66 |
| FBLIM1 | filamin binding LIM protein 1 | -0.58 |
| FADS1 | fatty acid desaturase 1 | -0.55 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.54 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.53 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.51 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.51 |
| KLHL5 | kelch-like family member 5 | -0.5 |
| SLC38A2 | solute carrier family 38, member 2 | -0.48 |
| FAM117A | family with sequence similarity 117, member A | -0.45 |
| APOBEC3F | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | -0.45 |
| ZNF114 | zinc finger protein 114 | -0.45 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.44 |
| PLK4 | polo-like kinase 4 | -0.43 |
| CALB2 | calbindin 2 | -0.43 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.43 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.43 |
| ZNF264 | zinc finger protein 264 | -0.42 |
| KRT222 | keratin 222, type II | -0.41 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.41 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.41 |
| STC2 | stanniocalcin 2 | -0.39 |
| SMAD3 | SMAD family member 3 | -0.39 |
| FN1 | fibronectin 1 | -0.37 |
| EREG | epiregulin | -0.36 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | -0.36 |
| NRP1 | neuropilin 1 | -0.36 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.35 |
| RAB43 | RAB43, member RAS oncogene family | -0.35 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.35 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | -0.34 |
| MRVI1 | murine retrovirus integration site 1 homolog | -0.34 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.34 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.33 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.33 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.33 |
| SHROOM1 | shroom family member 1 | -0.33 |
| SLC25A44 | solute carrier family 25, member 44 | -0.33 |
| ZNF518B | zinc finger protein 518B | -0.32 |
| CBX6 | chromobox homolog 6 | -0.32 |
| ZC4H2 | zinc finger, C4H2 domain containing | -0.32 |
| LIN37 | lin-37 DREAM MuvB core complex component | -0.32 |
| TNK2 | tyrosine kinase, non-receptor, 2 | -0.32 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.32 |
| SLC2A4RG | SLC2A4 regulator | -0.32 |
| CCDC59 | coiled-coil domain containing 59 | -0.32 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.32 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.32 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.31 |
| TRIM16 | tripartite motif containing 16 | -0.31 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.31 |
| NTAN1 | N-terminal asparagine amidase | -0.31 |
| NIBAN1 | niban apoptosis regulator 1 | -0.31 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.31 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | -0.31 |
| RAB19 | RAB19, member RAS oncogene family | -0.3 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -0.3 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.3 |
| ITGA6 | integrin, alpha 6 | -0.3 |
| ZSCAN31 | zinc finger and SCAN domain containing 31 | -0.3 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.3 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.3 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.3 |
| RIOX1 | ribosomal oxygenase 1 | -0.3 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.3 |
| UTP11 | UTP11 small subunit processome component | -0.3 |
| USP19 | ubiquitin specific peptidase 19 | -0.3 |
| CTSC | cathepsin C | -0.29 |
| CRYM | crystallin, mu | -0.29 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.29 |
| SESN2 | sestrin 2 | -0.29 |
| BCDIN3D | BCDIN3 domain containing | -0.29 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.29 |
| PEX12 | peroxisomal biogenesis factor 12 | -0.29 |
| MSMO1 | methylsterol monooxygenase 1 | -0.29 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | -0.29 |
| SQLE | squalene epoxidase | -0.28 |
| IGF1R | insulin-like growth factor 1 receptor | -0.28 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.28 |
| DUSP6 | dual specificity phosphatase 6 | -0.28 |
| FCF1 | FCF1 rRNA-processing protein | -0.28 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.28 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | -0.28 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.28 |
| CLIC4 | chloride intracellular channel 4 | -0.28 |
| GTPBP2 | GTP binding protein 2 | -0.28 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.28 |
| BRD3 | bromodomain containing 3 | -0.28 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.27 |
| PON3 | paraoxonase 3 | -0.27 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.27 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.27 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -0.26 |
| LAMB3 | laminin, beta 3 | -0.26 |
| EXD2 | exonuclease 3'-5' domain containing 2 | -0.26 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.26 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | -0.26 |
| GTF3A | general transcription factor IIIA | -0.26 |
