Genomic Instability Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity (Mammalian Phenotype Ontology, MP_0008866)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D042822
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Genes

145 genes/proteins associated with the disease Genomic Instability from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SIRT1 sirtuin 1 2.88009
SPRTN SprT-like N-terminal domain 2.88009
MGMT O-6-methylguanine-DNA methyltransferase 1.74321
EMP1 epithelial membrane protein 1 1.73798
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.6381
AXL AXL receptor tyrosine kinase 1.63698
KRT80 keratin 80, type II 1.63072
SFN stratifin 1.60571
GADD45A growth arrest and DNA-damage-inducible, alpha 1.59497
NQO1 NAD(P)H dehydrogenase, quinone 1 1.58113
PARP1 poly (ADP-ribose) polymerase 1 1.5433
EMP3 epithelial membrane protein 3 1.51784
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.51657
IER5 immediate early response 5 1.50248
TUBA4A tubulin, alpha 4a 1.49967
PROCR protein C receptor, endothelial 1.49096
GSTP1 glutathione S-transferase pi 1 1.48633
CRABP2 cellular retinoic acid binding protein 2 1.48556
TP53 tumor protein p53 1.46961
CCNB1 cyclin B1 1.44572
PCNA proliferating cell nuclear antigen 1.42913
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.40148
GJA1 gap junction protein, alpha 1, 43kDa 1.40008
HRAS Harvey rat sarcoma viral oncogene homolog 1.39451
LGALS7 lectin, galactoside-binding, soluble, 7 1.39002
BID BH3 interacting domain death agonist 1.36706
DPYSL4 dihydropyrimidinase-like 4 1.35934
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 1.35618
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.35473
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 1.34256
APAF1 apoptotic peptidase activating factor 1 1.3385
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.33553
CCNG1 cyclin G1 1.32993
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.32369
SPP1 secreted phosphoprotein 1 1.31956
BAX BCL2-associated X protein 1.31837
BAK1 BCL2-antagonist/killer 1 1.31387
RIPPLY3 ripply transcriptional repressor 3 1.31178
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.29843
FOSL1 FOS-like antigen 1 1.28549
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.28272
BCL2 B-cell CLL/lymphoma 2 1.28058
GCLC glutamate-cysteine ligase, catalytic subunit 1.27782
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.27595
SOD2 superoxide dismutase 2, mitochondrial 1.27595
GSTA4 glutathione S-transferase alpha 4 1.27286
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.26856
GDF15 growth differentiation factor 15 1.24275
MAPK1 mitogen-activated protein kinase 1 1.24118
IL6 interleukin 6 1.23868
FOS FBJ murine osteosarcoma viral oncogene homolog 1.23712
VIM vimentin 1.23616
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 1.23296
MARCKS myristoylated alanine-rich protein kinase C substrate 1.23106
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.22177
FASN fatty acid synthase 1.21663
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.21567
GSTA1 glutathione S-transferase alpha 1 1.21468
MR1 major histocompatibility complex, class I-related 1.20816
BCL2L1 BCL2-like 1 1.20493
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 1.20361
CCNA2 cyclin A2 1.20064
GSS glutathione synthetase 1.19704
GGT1 gamma-glutamyltransferase 1 1.19704
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.19574
ABHD3 abhydrolase domain containing 3 1.19477
HMOX1 heme oxygenase 1 1.18849
RTKN rhotekin 1.18652
BDNF brain-derived neurotrophic factor 1.18059
PARD3 par-3 family cell polarity regulator 1.17794
LGALS3 lectin, galactoside-binding, soluble, 3 1.17235
KIF1A kinesin family member 1A 1.17134
RAD51 RAD51 recombinase 1.1617
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.16001
CDC20 cell division cycle 20 1.15899
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.15797
FLNC filamin C, gamma 1.15695
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.15627
ACSL1 acyl-CoA synthetase long-chain family member 1 1.14781
IER3 immediate early response 3 1.14678
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.14575
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.14473
RDX radixin 1.1437
ERBB4 erb-b2 receptor tyrosine kinase 4 1.1403
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.13655
JUN jun proto-oncogene 1.13449
STOM stomatin 1.13381
CCND1 cyclin D1 1.13075
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 1.12771
CEL carboxyl ester lipase 1.12461
GSTM1 glutathione S-transferase mu 1 1.12426
TRIB3 tribbles pseudokinase 3 1.12254
LY6E lymphocyte antigen 6 complex, locus E 1.12117
BTG2 BTG family, member 2 1.12014
TMSB4X thymosin beta 4, X-linked 1.1198
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.11673
EGR1 early growth response 1 1.1129
FAS Fas cell surface death receptor 1.11151
CD59 CD59 molecule, complement regulatory protein 1.11081
BTG3 BTG family, member 3 1.11011
PLAU plasminogen activator, urokinase 1.09857
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.09716
TYMS thymidylate synthetase 1.09436
KRT17 keratin 17, type I 1.0894
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.08797
BIRC3 baculoviral IAP repeat containing 3 1.08584
EGFR epidermal growth factor receptor 1.08161
GSTM2 glutathione S-transferase mu 2 (muscle) 1.08091
MKI67 marker of proliferation Ki-67 1.07376
LAMC2 laminin, gamma 2 1.0734
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 1.07093
H2AFX H2A histone family, member X 1.06625
TOP2A topoisomerase (DNA) II alpha 170kDa 1.06625
PTEN phosphatase and tensin homolog 1.06625
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.06625
ATP13A4 ATPase type 13A4 1.06442
GLS glutaminase 1.0637
ISG15 ISG15 ubiquitin-like modifier 1.06188
SESN1 sestrin 1 1.05757
EDA2R ectodysplasin A2 receptor 1.05573
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.04831
ODC1 ornithine decarboxylase 1 1.04721
FYN FYN proto-oncogene, Src family tyrosine kinase 1.04684
GJB2 gap junction protein, beta 2, 26kDa 1.04163
IL10 interleukin 10 1.03901
HSPA2 heat shock 70kDa protein 2 1.03901
BCL2A1 BCL2-related protein A1 1.03827
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 1.03604
SESN2 sestrin 2 1.03308
KLF10 Kruppel-like factor 10 1.03159
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.02858
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.02671
DCN decorin 1.02634
STMN3 stathmin-like 3 1.02559
SPATA18 spermatogenesis associated 18 1.02447
GSTA2 glutathione S-transferase alpha 2 1.02373
NFE2L2 nuclear factor, erythroid 2-like 2 1.02299
GCLM glutamate-cysteine ligase, modifier subunit 1.02003
TXNRD1 thioredoxin reductase 1 1.02003
PHB prohibitin 1.01852
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.01625
GHR growth hormone receptor 1.01512
PLK2 polo-like kinase 2 1.01399
FN1 fibronectin 1 1.01361
SMAD2 SMAD family member 2 1.01137