Germinoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain. (Human Disease Ontology, DOID_3304)
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Genes

164 genes co-occuring with the disease Germinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
AFP alpha-fetoprotein 3.058
ALPP alkaline phosphatase, placental 3.016
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.658
SALL4 spalt-like transcription factor 4 2.398
POU5F1 POU class 5 homeobox 1 2.354
POMC proopiomelanocortin 2.172
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.103
PRL prolactin 2.081
TSPY1 testis specific protein, Y-linked 1 2.043
AVP arginine vasopressin 2.033
RPH3A rabphilin 3A 2.015
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.904
NANOS3 nanos homolog 3 (Drosophila) 1.903
SYP synaptophysin 1.894
PRDM14 PR domain containing 14 1.891
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 1.877
NANOG Nanog homeobox 1.808
EZHIP EZH inhibitory protein 1.795
IGF1 insulin-like growth factor 1 (somatomedin C) 1.776
KITLG KIT ligand 1.75
GPC3 glypican 3 1.73
ENO2 enolase 2 (gamma, neuronal) 1.72
NF1 neurofibromin 1 1.699
CD1E CD1e molecule 1.674
KIAA1549 KIAA1549 1.672
CD1A CD1a molecule 1.663
CD1B CD1b molecule 1.656
LIN28A lin-28 homolog A (C. elegans) 1.655
GFAP glial fibrillary acidic protein 1.607
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.603
CD1C CD1c molecule 1.587
TBX19 T-box 19 1.582
PROP1 PROP paired-like homeobox 1 1.581
CD99 CD99 molecule 1.58
DAZL deleted in azoospermia-like 1.579
RUNDC3A RUN domain containing 3A 1.568
CD99L2 CD99 molecule-like 2 1.564
SOX17 SRY (sex determining region Y)-box 17 1.542
TP53 tumor protein p53 1.538
CD1D CD1d molecule 1.528
TRA2A transformer 2 alpha homolog (Drosophila) 1.525
UTF1 undifferentiated embryonic cell transcription factor 1 1.524
H3-3A H3.3 histone A 1.522
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.513
SPRY4 sprouty homolog 4 (Drosophila) 1.509
BAK1 BCL2-antagonist/killer 1 1.507
GHRH growth hormone releasing hormone 1.489
CCND2 cyclin D2 1.479
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.473
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.472
DPPA3 developmental pluripotency associated 3 1.47
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 1.467
JMJD1C jumonji domain containing 1C 1.462
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.458
CSH2 chorionic somatomammotropin hormone 2 1.449
C6ORF136 chromosome 6 open reading frame 136 1.446
MAGEB16 melanoma antigen family B16 1.446
CD274 CD274 molecule 1.43
TCF4 transcription factor 4 1.427
KRAS Kirsten rat sarcoma viral oncogene homolog 1.426
KLHL11 kelch-like family member 11 1.417
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.414
DDIT4L DNA-damage-inducible transcript 4-like 1.402
SOX2 SRY (sex determining region Y)-box 2 1.398
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.398
CD207 CD207 molecule, langerin 1.393
CD72 CD72 molecule 1.389
SHH sonic hedgehog 1.381
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.381
ZNF593 zinc finger protein 593 1.377
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.369
H3C2 H3 clustered histone 2 1.353
ACE angiotensin I converting enzyme 1.35
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.347
DMRT1 doublesex and mab-3 related transcription factor 1 1.343
RTRAF RNA transcription, translation and transport factor 1.331
SLC6A16 solute carrier family 6, member 16 1.321
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.313
CDCA7L cell division cycle associated 7-like 1.313
TRH thyrotropin-releasing hormone 1.31
MGMT O-6-methylguanine-DNA methyltransferase 1.309
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.308
LEFTY1 left-right determination factor 1 1.307
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.304
MAGEB1 melanoma antigen family B1 1.297
CEP85 centrosomal protein 85kDa 1.29
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.285
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.281
SPESP1 sperm equatorial segment protein 1 1.279
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.263
LHX3 LIM homeobox 3 1.259
CD68 CD68 molecule 1.254
CRH corticotropin releasing hormone 1.249
HIC1 hypermethylated in cancer 1 1.248
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 1.247
SCGB3A1 secretoglobin, family 3A, member 1 1.245
GH1 growth hormone 1 1.242
PHTF2 putative homeodomain transcription factor 2 1.239
PNMA2 paraneoplastic Ma antigen 2 1.227
OLIG2 oligodendrocyte lineage transcription factor 2 1.223
NKX2-1 NK2 homeobox 1 1.216
SVIL supervillin 1.214
CHGA chromogranin A 1.209
KLF4 Kruppel-like factor 4 (gut) 1.208
H3Y2 H3.Y histone 2 1.207
GATA6 GATA binding protein 6 1.205
TDRD12 tudor domain containing 12 1.203
POU1F1 POU class 1 homeobox 1 1.197
PCDHGC4 protocadherin gamma subfamily C, 4 1.197
TENT5B terminal nucleotidyltransferase 5B 1.194
PDPN podoplanin 1.194
PTPRC protein tyrosine phosphatase, receptor type, C 1.187
MAGEA4 melanoma antigen family A4 1.185
CDKN2A cyclin-dependent kinase inhibitor 2A 1.183
DPPA4 developmental pluripotency associated 4 1.181
CD8A CD8a molecule 1.179
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.178
PCDHGC5 protocadherin gamma subfamily C, 5 1.178
RRAS2 related RAS viral (r-ras) oncogene homolog 2 1.175
EFCAB2 EF-hand calcium binding domain 2 1.175
ZNF296 zinc finger protein 296 1.171
NR4A1AS NR4A1 antisense RNA 1.17
TSC22D1 TSC22 domain family, member 1 1.169
KRT7 keratin 7, type II 1.168
H3C3 H3 clustered histone 3 1.153
HESX1 HESX homeobox 1 1.152
ATF7IP activating transcription factor 7 interacting protein 1.151
AUNIP aurora kinase A and ninein interacting protein 1.145
PRDM1 PR domain containing 1, with ZNF domain 1.142
CREBL2 cAMP responsive element binding protein-like 2 1.142
INS insulin 1.14
RSRC2 arginine/serine-rich coiled-coil 2 1.132
CD4 CD4 molecule 1.116
GDF3 growth differentiation factor 3 1.113
DND1 DND microRNA-mediated repression inhibitor 1 1.112
EGFR epidermal growth factor receptor 1.108
OXT oxytocin/neurophysin I prepropeptide 1.106
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 1.106
GTSF1 gametocyte specific factor 1 1.1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.097
IGSF1 immunoglobulin superfamily, member 1 1.091
H3-3B H3.3 histone B 1.087
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.082
PXMP2 peroxisomal membrane protein 2, 22kDa 1.077
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.074
TERT telomerase reverse transcriptase 1.064
ELOVL6 ELOVL fatty acid elongase 6 1.061
IGFBP3 insulin-like growth factor binding protein 3 1.061
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.061
GGCT gamma-glutamylcyclotransferase 1.061
CD34 CD34 molecule 1.058
ADAP1 ArfGAP with dual PH domains 1 1.04
PTEN phosphatase and tensin homolog 1.039
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.038
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.029
SOX10 SRY (sex determining region Y)-box 10 1.026
ZSCAN4 zinc finger and SCAN domain containing 4 1.022
DICER1 dicer 1, ribonuclease type III 1.02
ENO1 enolase 1, (alpha) 1.014
EGFL8 EGF-like-domain, multiple 8 1.013
LEUTX leucine twenty homeobox 1.013
TSPYL1 TSPY-like 1 1.012
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.008
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.004