Giant Cell Glioblastoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A glioblastoma multiforme that is characterized by a prevalence of bizarre, multinucleated giant cells. (Human Disease Ontology, DOID_3074)
External Link https://www.disgenet.org/browser/0/1/0/C0334588
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Genes

94 genes associated with the disease Giant Cell Glioblastoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
APC adenomatous polyposis coli
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKB aurora kinase B
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C5ORF30 chromosome 5 open reading frame 30
CCDC67 coiled-coil domain containing 67
CCNH cyclin H
CD9 CD9 molecule
CDK6 cyclin-dependent kinase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTNND2 catenin (cadherin-associated protein), delta 2
CTSB cathepsin B
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
EGF epidermal growth factor
EGFR epidermal growth factor receptor
FAT1 FAT atypical cadherin 1
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
GDNF glial cell derived neurotrophic factor
GRIK2 glutamate receptor, ionotropic, kainate 2
GSTT1 glutathione S-transferase theta 1
H2AX H2A.X variant histone
H3F3A H3 histone, family 3A
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H3B histone cluster 1, H3b
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA2 interferon, alpha 2
IL1B interleukin 1, beta
IL2 interleukin 2
JAG1 jagged 1
JAG2 jagged 2
LRRC59 leucine rich repeat containing 59
LTBP4 latent transforming growth factor beta binding protein 4
LZTR1 leucine-zipper-like transcription regulator 1
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
OLIG2 oligodendrocyte lineage transcription factor 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PML promyelocytic leukemia
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLK polymerase (DNA directed) kappa
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SEPTIN14 septin 14
SETD2 SET domain containing 2
SLC22A10 solute carrier family 22, member 10
SOD1 superoxide dismutase 1, soluble
SRRT serrate, RNA effector molecule
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TES testin LIM domain protein
TGM2 transglutaminase 2
TMEM135 transmembrane protein 135
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZBTB7A zinc finger and BTB domain containing 7A