| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.193843 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.161312 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.155201 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.125639 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0867971 |
| NAV2 | neuron navigator 2 | 0.0844952 |
| FLNB | filamin B, beta | 0.0808276 |
| PLAT | plasminogen activator, tissue | 0.0793165 |
| PODXL | podocalyxin-like | 0.0785658 |
| MYOF | myoferlin | 0.0727082 |
| ATP13A3 | ATPase type 13A3 | 0.0638454 |
| OGA | O-GlcNAcase | 0.0616937 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.058622 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0568747 |
| SLC39A11 | solute carrier family 39, member 11 | 0.054943 |
| RUNX1 | runt-related transcription factor 1 | 0.0544732 |
| PRELID2 | PRELI domain containing 2 | 0.0539865 |
| LOXL2 | lysyl oxidase-like 2 | 0.0518612 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0470873 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0448822 |
| CD109 | CD109 molecule | 0.0432542 |
| YEATS2 | YEATS domain containing 2 | 0.0427556 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0426024 |
| GOLGA4 | golgin A4 | 0.0424316 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0423747 |
| NDRG1 | N-myc downstream regulated 1 | 0.0423273 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0414521 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0408413 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0405917 |
| INSIG2 | insulin induced gene 2 | 0.0401725 |
| ZNF292 | zinc finger protein 292 | 0.0397419 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.037999 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0371848 |
| OPTN | optineurin | 0.0360935 |
| C1D | C1D nuclear receptor corepressor | 0.0359933 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0359468 |
| SBF2 | SET binding factor 2 | 0.0355495 |
| AFDN | afadin, adherens junction formation factor | 0.0349419 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0345653 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0342937 |
| SP3 | Sp3 transcription factor | 0.0341312 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0335382 |
| SEPTIN9 | septin 9 | 0.0324364 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0317242 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0310028 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.030947 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0307953 |
| STC1 | stanniocalcin 1 | 0.0306328 |
| MSN | moesin | 0.0305104 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0304378 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0303323 |
| CDK18 | cyclin-dependent kinase 18 | 0.0302405 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0297312 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0297299 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0287809 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0287484 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0285852 |
| FBN1 | fibrillin 1 | 0.0281674 |
| NBAS | neuroblastoma amplified sequence | 0.0280612 |
| NCOR2 | nuclear receptor corepressor 2 | 0.028019 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.027873 |
| FRMD4A | FERM domain containing 4A | 0.0276988 |
| FNIP1 | folliculin interacting protein 1 | 0.0275661 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0275468 |
| AFF3 | AF4/FMR2 family, member 3 | 0.026943 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0268097 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0267458 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0265819 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0265277 |
| WDR26 | WD repeat domain 26 | 0.0262367 |
| FOSL1 | FOS-like antigen 1 | 0.026225 |
| PGK1 | phosphoglycerate kinase 1 | 0.0261674 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0259497 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0259362 |
| APP | amyloid beta (A4) precursor protein | 0.0256836 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.025669 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0253816 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0253264 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0252682 |
| SQSTM1 | sequestosome 1 | 0.0251815 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0251733 |
| MT2A | metallothionein 2A | 0.0249103 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0246602 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0245042 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0244963 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0242479 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0241905 |
| USP34 | ubiquitin specific peptidase 34 | 0.0240062 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0235926 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0232432 |
| SET | SET nuclear proto-oncogene | 0.0231077 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0228478 |
| AUTS2 | autism susceptibility candidate 2 | 0.0227804 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0227405 |
| MXI1 | MAX interactor 1, dimerization protein | 0.022735 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.022723 |
| SETD5 | SET domain containing 5 | 0.02263 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0225117 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0223726 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0223459 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.194184 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.142177 |
| TMSB10 | thymosin beta 10 | -0.141902 |
| MAP1B | microtubule-associated protein 1B | -0.0966546 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0897771 |
| LOX | lysyl oxidase | -0.0703144 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0636851 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0601018 |
| RIGI | RNA sensor RIG-I | -0.0575546 |
| S100A10 | S100 calcium binding protein A10 | -0.05672 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0554288 |
| MEIS2 | Meis homeobox 2 | -0.0531594 |
| VIM | vimentin | -0.0518693 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0506927 |
| MX2 | MX dynamin-like GTPase 2 | -0.0498645 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0497656 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0483481 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0475985 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0463338 |
| HLA-B | major histocompatibility complex, class I, B | -0.0438705 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0435178 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0421355 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0419376 |
| VCL | vinculin | -0.04133 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0405222 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0401084 |
| ANXA2 | annexin A2 | -0.0399891 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.039598 |
| SUCNR1 | succinate receptor 1 | -0.0394396 |
| CD44 | CD44 molecule (Indian blood group) | -0.0382368 |
| FTL | ferritin, light polypeptide | -0.0378487 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0377781 |
| HLA-C | major histocompatibility complex, class I, C | -0.0375985 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0373965 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0372815 |
| SP100 | SP100 nuclear antigen | -0.0371759 |
| S100A6 | S100 calcium binding protein A6 | -0.0366056 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0360523 |
| UBC | ubiquitin C | -0.0345675 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0336843 |
| NAV1 | neuron navigator 1 | -0.0327864 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0325703 |
| FN1 | fibronectin 1 | -0.0322166 |
| RPL35A | ribosomal protein L35a | -0.031525 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0314163 |
| FSTL1 | follistatin-like 1 | -0.0309736 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0309734 |
| GNAS | GNAS complex locus | -0.0308081 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.029205 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0291991 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0285416 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0284296 |
| TUBB | tubulin, beta class I | -0.0282306 |
| ACTG1 | actin gamma 1 | -0.0282266 |
| PRSS23 | protease, serine, 23 | -0.0281425 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.027224 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0270482 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0267748 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0267511 |
| ACTN4 | actinin, alpha 4 | -0.0265838 |
| VDAC1 | voltage-dependent anion channel 1 | -0.026563 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0264253 |
| FNDC3A | fibronectin type III domain containing 3A | -0.025181 |
| CANX | calnexin | -0.0251626 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0251129 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0251121 |
| FBXO11 | F-box protein 11 | -0.0251058 |
| RTN4 | reticulon 4 | -0.0250237 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0249208 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.024804 |
| RASAL2 | RAS protein activator like 2 | -0.0247844 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0241453 |
| NPR2 | natriuretic peptide receptor 2 | -0.0224835 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0224763 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0223443 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0222554 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0219236 |
| BSG | basigin (Ok blood group) | -0.0219185 |
| CALR | calreticulin | -0.0218464 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0218307 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0218099 |
| TXNIP | thioredoxin interacting protein | -0.0214421 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0213809 |
| CSTB | cystatin B (stefin B) | -0.0212447 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0209678 |
| TAGLN2 | transgelin 2 | -0.0208457 |
| RPL34 | ribosomal protein L34 | -0.0208026 |
| PLXNA2 | plexin A2 | -0.0205773 |
| ARF1 | ADP-ribosylation factor 1 | -0.0204972 |
| SON | SON DNA binding protein | -0.0201412 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0201157 |
| H3-3B | H3.3 histone B | -0.0200747 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0198982 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0197608 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0195019 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0193583 |
| CDK12 | cyclin-dependent kinase 12 | -0.0193537 |
| PCDH7 | protocadherin 7 | -0.0191254 |
| B2M | beta-2-microglobulin | -0.0189158 |
| CCND1 | cyclin D1 | -0.0188596 |
