| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Glasdegib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Glasdegib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.072817 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0467745 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.044423 |
| CPOX | coproporphyrinogen oxidase | 0.0438314 |
| AREG | amphiregulin | 0.0404473 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0371175 |
| CCNL1 | cyclin L1 | 0.0354772 |
| NEK7 | NIMA-related kinase 7 | 0.0341935 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0334584 |
| ZNF292 | zinc finger protein 292 | 0.0313763 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0311849 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0301233 |
| EPHA6 | EPH receptor A6 | 0.0295902 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0295447 |
| THOC1 | THO complex 1 | 0.0269849 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0262721 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0258492 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0257448 |
| MED13L | mediator complex subunit 13-like | 0.0256226 |
| YEATS2 | YEATS domain containing 2 | 0.0254262 |
| OXR1 | oxidation resistance 1 | 0.0249784 |
| CDK19 | cyclin-dependent kinase 19 | 0.0246486 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0242902 |
| CLDND1 | claudin domain containing 1 | 0.0240277 |
| OGA | O-GlcNAcase | 0.0239264 |
| PNN | pinin, desmosome associated protein | 0.0238172 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0233565 |
| TFG | TRK-fused gene | 0.0230724 |
| GASK1B | golgi associated kinase 1B | 0.022973 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0227911 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0226396 |
| MGAT4C | MGAT4 family, member C | 0.0220643 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0220575 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0218328 |
| CEP192 | centrosomal protein 192kDa | 0.0216144 |
| RNF145 | ring finger protein 145 | 0.0215562 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0210973 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.02078 |
| ETNK1 | ethanolamine kinase 1 | 0.0204211 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0201747 |
| ARRDC3 | arrestin domain containing 3 | 0.0201212 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0200027 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0199891 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0198109 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0197483 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0196559 |
| PCBP2 | poly(rC) binding protein 2 | 0.0194162 |
| NCKAP1 | NCK-associated protein 1 | 0.0192606 |
| SETD5 | SET domain containing 5 | 0.0192517 |
| MATR3 | matrin 3 | 0.0191481 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0187254 |
| SET | SET nuclear proto-oncogene | 0.0182207 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0181252 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0180164 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0179936 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0178498 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0174515 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0173785 |
| ATP11A | ATPase, class VI, type 11A | 0.0173774 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0173493 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0173437 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0172928 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0172617 |
| CASC3 | cancer susceptibility candidate 3 | 0.0172383 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0171854 |
| KLHL24 | kelch-like family member 24 | 0.0170682 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0167086 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0167055 |
| SUCO | SUN domain containing ossification factor | 0.0165049 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.016489 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.016314 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0161917 |
| TXNRD1 | thioredoxin reductase 1 | 0.0161912 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0161693 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0161682 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0160806 |
| PLK2 | polo-like kinase 2 | 0.0158798 |
| COG5 | component of oligomeric golgi complex 5 | 0.0156651 |
| AFDN | afadin, adherens junction formation factor | 0.015579 |
| RPL3 | ribosomal protein L3 | 0.0154536 |
| CDC73 | cell division cycle 73 | 0.0153355 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0153112 |
| RBM26 | RNA binding motif protein 26 | 0.0152497 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0151769 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0149845 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0149149 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0148617 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0148307 |
| KIF5B | kinesin family member 5B | 0.01479 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0147112 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0147051 |
| VMP1 | vacuole membrane protein 1 | 0.014602 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0145893 |
| SLC49A4 | solute carrier family 49 member 4 | 0.0145148 |
| GOLGA4 | golgin A4 | 0.0143354 |
| PER1 | period circadian clock 1 | 0.0142714 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0142418 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0141643 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0140565 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.0140011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.313403 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.281707 |
| NLGN1 | neuroligin 1 | -0.241756 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.237048 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.167281 |
| TMSB10 | thymosin beta 10 | -0.163658 |
| ACTG1 | actin gamma 1 | -0.122892 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.099905 |
| HMGA2 | high mobility group AT-hook 2 | -0.0998186 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0891264 |
| PCDH7 | protocadherin 7 | -0.0861561 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0824644 |
| RAB7A | RAB7A, member RAS oncogene family | -0.082287 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0780219 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0777562 |
| MYL12B | myosin, light chain 12B, regulatory | -0.07429 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0728686 |
| FTL | ferritin, light polypeptide | -0.0674419 |
| ZNF804A | zinc finger protein 804A | -0.0636931 |
| JMJD1C | jumonji domain containing 1C | -0.0609084 |
| EHBP1 | EH domain binding protein 1 | -0.0599425 |
| RPL35A | ribosomal protein L35a | -0.0572584 |
| EGR1 | early growth response 1 | -0.0563931 |
| MKI67 | marker of proliferation Ki-67 | -0.0553554 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0539485 |
| TPI1 | triosephosphate isomerase 1 | -0.0516866 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0516071 |
| CALR | calreticulin | -0.0514197 |
| PTMA | prothymosin, alpha | -0.0513111 |
| CCND1 | cyclin D1 | -0.0511523 |
| ADIPOR2 | adiponectin receptor 2 | -0.0469085 |
| RASAL2 | RAS protein activator like 2 | -0.0466285 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0459848 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0451255 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0448664 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0447767 |
| TUBA1B | tubulin, alpha 1b | -0.0447219 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0446843 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0444197 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.044394 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.04371 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0436821 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0432011 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0425328 |
| ASPH | aspartate beta-hydroxylase | -0.0423863 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0414197 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0400482 |
| RPS27A | ribosomal protein S27a | -0.039581 |
| CANX | calnexin | -0.0392226 |
| CUX1 | cut-like homeobox 1 | -0.039173 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0385936 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0379995 |
| RPS8 | ribosomal protein S8 | -0.0379864 |
| NHSL1 | NHS-like 1 | -0.0378798 |
| CMIP | c-Maf inducing protein | -0.0378795 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0377516 |
| AHNAK | AHNAK nucleoprotein | -0.0374252 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0372583 |
| GNAS | GNAS complex locus | -0.0363898 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0361723 |
| PRDX1 | peroxiredoxin 1 | -0.0355442 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0354467 |
| RPLP1 | ribosomal protein, large, P1 | -0.0351686 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0348979 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0348328 |
| HMGA1 | high mobility group AT-hook 1 | -0.0344359 |
| S100A10 | S100 calcium binding protein A10 | -0.0344099 |
| RPL19 | ribosomal protein L19 | -0.0342644 |
| MAP1B | microtubule-associated protein 1B | -0.0341927 |
| DST | dystonin | -0.0336065 |
| YAP1 | Yes-associated protein 1 | -0.0333983 |
| HSPB1 | heat shock 27kDa protein 1 | -0.033105 |
| TPM4 | tropomyosin 4 | -0.0328635 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0325131 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0325123 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0322569 |
| LDHA | lactate dehydrogenase A | -0.0319837 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0311226 |
| EDARADD | EDAR-associated death domain | -0.0310704 |
| AFF4 | AF4/FMR2 family, member 4 | -0.030632 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0304957 |
| GCG | glucagon | -0.0304934 |
| BRI3BP | BRI3 binding protein | -0.0303948 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0300006 |
| S100A6 | S100 calcium binding protein A6 | -0.0296467 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0295696 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0294805 |
| RPL34 | ribosomal protein L34 | -0.0286864 |
| YBX3 | Y box binding protein 3 | -0.0284847 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0282687 |
| NAV3 | neuron navigator 3 | -0.0282192 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0281375 |
| TUBB | tubulin, beta class I | -0.0279851 |
| INTS6 | integrator complex subunit 6 | -0.0277118 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0276293 |
| RPL37 | ribosomal protein L37 | -0.0276057 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0271832 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0269197 |
| CLDN1 | claudin 1 | -0.0269005 |
| RPS24 | ribosomal protein S24 | -0.0268696 |
