Glasdegib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Glasdegib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Glasdegib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.130539
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.123384
HELZ helicase with zinc finger 0.0910305
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0722609
WDR45B WD repeat domain 45B 0.0606077
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0589255
AKAP12 A kinase (PRKA) anchor protein 12 0.0569777
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0560134
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0548888
OGA O-GlcNAcase 0.0545035
NPEPPS aminopeptidase puromycin sensitive 0.0541596
DSCAM Down syndrome cell adhesion molecule 0.0493982
ZNF292 zinc finger protein 292 0.0490237
KMT2C lysine (K)-specific methyltransferase 2C 0.0482719
CASC3 cancer susceptibility candidate 3 0.0446853
GOLGA4 golgin A4 0.0438477
UBA6 ubiquitin-like modifier activating enzyme 6 0.0413454
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0412101
DTNA dystrobrevin, alpha 0.0407849
WAC WW domain containing adaptor with coiled-coil 0.039905
KMT2E lysine (K)-specific methyltransferase 2E 0.0391539
TLK2 tousled-like kinase 2 0.0388117
DDIT4 DNA-damage-inducible transcript 4 0.0376581
PTK2 protein tyrosine kinase 2 0.0372156
RNF145 ring finger protein 145 0.0368958
NAMPT nicotinamide phosphoribosyltransferase 0.0368906
KDM3A lysine (K)-specific demethylase 3A 0.0366078
SETD5 SET domain containing 5 0.0361553
FNBP1 formin binding protein 1 0.0355621
NDRG1 N-myc downstream regulated 1 0.0343762
FNDC3B fibronectin type III domain containing 3B 0.0339289
XPO1 exportin 1 0.0331475
COPA coatomer protein complex, subunit alpha 0.0328241
YEATS2 YEATS domain containing 2 0.0325767
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0324486
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0306415
SSBP3 single stranded DNA binding protein 3 0.0303037
MXI1 MAX interactor 1, dimerization protein 0.029798
ADGRG6 adhesion G protein-coupled receptor G6 0.0296987
NUP58 nucleoporin 58 0.0290913
CD46 CD46 molecule, complement regulatory protein 0.0287463
CCNY cyclin Y 0.0287387
ESYT2 extended synaptotagmin-like protein 2 0.0279085
MEF2A myocyte enhancer factor 2A 0.027902
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0278741
SUCO SUN domain containing ossification factor 0.0275342
CD36 CD36 molecule (thrombospondin receptor) 0.0272885
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0269002
RNMT RNA (guanine-7-) methyltransferase 0.0268291
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0268016
SSBP2 single-stranded DNA binding protein 2 0.0267864
SPAG9 sperm associated antigen 9 0.0267775
NBAS neuroblastoma amplified sequence 0.026544
SET SET nuclear proto-oncogene 0.0263217
INSIG2 insulin induced gene 2 0.0262751
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0262183
ZNF148 zinc finger protein 148 0.025744
PRRC2C proline-rich coiled-coil 2C 0.0252185
WDR43 WD repeat domain 43 0.0251113
YTHDC1 YTH domain containing 1 0.0247924
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0246586
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0245664
PDE8A phosphodiesterase 8A 0.0245072
RTN4 reticulon 4 0.0244431
SCAF11 SR-related CTD-associated factor 11 0.0243725
PGK1 phosphoglycerate kinase 1 0.0243149
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0242499
KCTD3 potassium channel tetramerization domain containing 3 0.023942
QKI QKI, KH domain containing, RNA binding 0.0238772
AFDN afadin, adherens junction formation factor 0.023721
BCLAF1 BCL2-associated transcription factor 1 0.0237012
CENPF centromere protein F, 350/400kDa 0.0236935
LPIN1 lipin 1 0.0233754
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0233562
NGLY1 N-glycanase 1 0.0228216
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0225038
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0224774
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.022369
HOOK2 hook microtubule-tethering protein 2 0.0221801
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0221174
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0220943
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0219644
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0214462
PNISR PNN-interacting serine/arginine-rich protein 0.0214446
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0214337
CDON cell adhesion associated, oncogene regulated 0.0214187
GIGYF2 GRB10 interacting GYF protein 2 0.0213913
TOP2B topoisomerase (DNA) II beta 180kDa 0.0213563
NCKAP1 NCK-associated protein 1 0.021239
CHD1 chromodomain helicase DNA binding protein 1 0.0210923
ZNF654 zinc finger protein 654 0.0204778
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0203764
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0202911
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0201901
PICALM phosphatidylinositol binding clathrin assembly protein 0.0201104
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0199951
SREBF2 sterol regulatory element binding transcription factor 2 0.0199464
ERRFI1 ERBB receptor feedback inhibitor 1 0.0199211
SBF2 SET binding factor 2 0.0197897
SNX13 sorting nexin 13 0.0197258

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209927
IGF2 insulin-like growth factor 2 -0.199681
VCL vinculin -0.164787
ACTG1 actin gamma 1 -0.0962651
FMN1 formin 1 -0.0948065
PTPRD protein tyrosine phosphatase, receptor type, D -0.0894355
LSAMP limbic system-associated membrane protein -0.0885729
TLE4 transducin-like enhancer of split 4 -0.0861154
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0775401
NRG1 neuregulin 1 -0.0774374
VMP1 vacuole membrane protein 1 -0.0719698
SYT1 synaptotagmin I -0.0710585
BCAS3 breast carcinoma amplified sequence 3 -0.0641524
RPL23 ribosomal protein L23 -0.063979
RPL35A ribosomal protein L35a -0.0609818
BPTF bromodomain PHD finger transcription factor -0.0597848
NALF1 NALCN channel auxiliary factor 1 -0.0581869
EIF1 eukaryotic translation initiation factor 1 -0.0571683
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0569821
RPLP1 ribosomal protein, large, P1 -0.0564841
RPL38 ribosomal protein L38 -0.0558169
RPL19 ribosomal protein L19 -0.0543748
VIM vimentin -0.0525159
RNF213 ring finger protein 213 -0.0523399
EGR1 early growth response 1 -0.050953
RPL34 ribosomal protein L34 -0.050881
IFI16 interferon, gamma-inducible protein 16 -0.0464845
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0424734
PTPRK protein tyrosine phosphatase, receptor type, K -0.0424139
TPM1 tropomyosin 1 (alpha) -0.0416583
LINGO2 leucine rich repeat and Ig domain containing 2 -0.041187
RPS24 ribosomal protein S24 -0.0406755
GLCCI1 glucocorticoid induced 1 -0.0399735
TMSB10 thymosin beta 10 -0.0388105
ZNF804A zinc finger protein 804A -0.0385601
BICD1 bicaudal D homolog 1 (Drosophila) -0.0380767
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0365724
RPS23 ribosomal protein S23 -0.0356176
RPL27 ribosomal protein L27 -0.0349307
GREM2 gremlin 2, DAN family BMP antagonist -0.0346363
PTMA prothymosin, alpha -0.0345086
SLIT2 slit homolog 2 (Drosophila) -0.033767
RPL31 ribosomal protein L31 -0.0332774
RPS19 ribosomal protein S19 -0.0331508
COL1A1 collagen, type I, alpha 1 -0.0330535
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0327006
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0326178
FTL ferritin, light polypeptide -0.0325386
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0325261
ANTXR1 anthrax toxin receptor 1 -0.0325024
ZBTB20 zinc finger and BTB domain containing 20 -0.0324767
RPS12 ribosomal protein S12 -0.0324089
RIGI RNA sensor RIG-I -0.0321528
PRKCA protein kinase C, alpha -0.0318733
RPLP0 ribosomal protein, large, P0 -0.0318425
DPH6 diphthamine biosynthesis 6 -0.0317403
INTS6 integrator complex subunit 6 -0.0315772
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0310182
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0310057
H3-3B H3.3 histone B -0.0308767
MCL1 myeloid cell leukemia 1 -0.030841
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0304544
PLPP1 phospholipid phosphatase 1 -0.0304362
TPT1 tumor protein, translationally-controlled 1 -0.0300284
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0297196
TPST1 tyrosylprotein sulfotransferase 1 -0.0294806
PDZRN3 PDZ domain containing ring finger 3 -0.0292385
SIK2 salt-inducible kinase 2 -0.0292173
ATRNL1 attractin-like 1 -0.0290422
THSD4 thrombospondin, type I, domain containing 4 -0.0288845
UNC5C unc-5 homolog C (C. elegans) -0.0288663
FNDC3A fibronectin type III domain containing 3A -0.0288434
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0285904
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0285847
KLHL13 kelch-like family member 13 -0.0285116
RPS27 ribosomal protein S27 -0.0283907
MX2 MX dynamin-like GTPase 2 -0.0282881
TPM4 tropomyosin 4 -0.0282078
LOC112694756 uncharaterized LOC112694756 -0.0274294
FERMT2 fermitin family member 2 -0.0270955
STXBP4 syntaxin binding protein 4 -0.0270251
SMYD3 SET and MYND domain containing 3 -0.0268884
RPS6 ribosomal protein S6 -0.0268193
TENM4 teneurin transmembrane protein 4 -0.0268167
PLAT plasminogen activator, tissue -0.026618
STK38L serine/threonine kinase 38 like -0.0259938
RPL12 ribosomal protein L12 -0.0259613
HAND2 heart and neural crest derivatives expressed 2 -0.0258803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0257394
CADM2 cell adhesion molecule 2 -0.0255254
ACTN1 actinin, alpha 1 -0.0254373
PCNX4 pecanex 4 -0.025372
RPL9 ribosomal protein L9 -0.0253673
TRPS1 trichorhinophalangeal syndrome I -0.0253005
AEBP2 AE binding protein 2 -0.0253
TBX2 T-box 2 -0.0251641
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0250955
CNTN4 contactin 4 -0.0250854
RAB7A RAB7A, member RAS oncogene family -0.0250269
RPL32 ribosomal protein L32 -0.0249888